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NEFL: neurofilament light chain

1 protein, 72 patents, 0 drugs, 0 trials, 4,073 NIH grants and 9,579 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNEFLHGNC
Nameneurofilament light chainHGNC
NCBI Gene ID4747NCBI Gene
HGNC IDHGNC:7739HGNC
EnsemblENSG00000277586NCBI Gene
AliasesCMT1F, CMT2E, CMTDIG, NF-L, NF68, NFL, PPP1R110NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P07196Neurofilament light polypeptide5430Ensembl, GeneID, HGNCUniProt

Patents 72

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026520274 A2026-06-231P07196Espacenet
JP 2026082837 A2026-05-1917P07196Espacenet
JP 2026513515 A2026-04-289P07196Espacenet
JP 2026511426 A2026-04-141P07196Espacenet
EP 4705767 A12026-03-111P07196Espacenet
US 12560619 B22026-02-2479P07196Espacenet
EP 4680970 A12026-01-219P07196Espacenet
EP 4681225 A12026-01-211P07196Espacenet
JP 2025032204 A2025-03-1132224P07196Espacenet
US 12247986 B22025-03-112P07196Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 4073

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30AG066444Alzheimer's Disease Research Center422,025NIH's project files
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study402,025NIH's project files
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)372,025NIH's project files
P30AG062715Wisconsin Alzheimer's Disease Research Center332,025NIH's project files
R01AG027161Wisconsin Registry for Alzheimer's Prevention322,025NIH's project files
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions312,025NIH's project files
U19AG063911ARTFL LEFFTDS Longitudinal Frontotemporal Lobar Degeneration, Cycle 2 (ALLFTD2)302,025NIH's project files
R01AG021155The Longitudinal Course of Imaging Biomarkers in People At Risk for Alzheimer’s Disease292,025NIH's project files
U19AG032438Bridge Funding for Dominantly Inherited Alzheimer Network262,025NIH's project files
R01AG083874Plasma brain-derived tau: a novel Alzheimer’s disease-type neurodegeneration biomarker with potential to complete the AT(N) scheme in blood252,025NIH's project files

Papers 9579

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827143PubTator, text miningPubMed
42825398PubTator, text miningPubMed
42825117PubTator, text miningPubMed
42824090PubTator, text miningPubMed
42818102PubTator, text miningPubMed
42817696PubTator, text miningPubMed
42817153PubTator, text miningPubMed
42810842PubTator, text miningPubMed
42809446PubTator, text miningPubMed
42807379PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license