Gene · 4751
NEK2: NIMA related kinase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NEK2: NIMA related kinase 2. Genes, record 4751. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4751
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P51955 | Serine/threonine-protein kinase Nek2 | 445 | 30 | Ensembl, GeneID, HGNC |
Source UniProt
Patents57
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 47 | P51955 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 55744 | P51955 | Espacenet |
| EP 4641202 A2 | 2025-10-29 | 5376 | P51955 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 32233 | P51955 | Espacenet |
| KR 1020250017231 A | 2025-02-04 | 5376 | P51955 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 32233 | P51955 | Espacenet |
| US 12130292 B2 | 2024-10-29 | 30 | P51955 | Espacenet |
| WO 2024214081 A1 | 2024-10-17 | 47 | P51955 | Espacenet |
| US 11892452 B2 | 2024-02-06 | 5 | P51955 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 32233 | P51955 | Espacenet |
1 to 10 of 57
See all 57 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,164
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NEK2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA086862 | Cancer Center Support Grant | 18 | 2025 |
| U54CA163071 | (1/2) Ponce Health Sciences University-Moffitt Cancer Center Partnership # | 8 | 2025 |
| U54CA163068 | 2/2 Ponce Health Sciences University-Moffitt Cancer Center Partnership | 7 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 6 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 6 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 5 | 2025 |
| T32HL007344 | Program in Hematology: Molecular & Cell Biology of Blood Cells | 5 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 4 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 4 | 2025 |
| P30ES017885 | Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD) | 4 | 2025 |
1 to 10 of 1,164Source NIH's project files
See all 1,164 nih grantsPapers2,227
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Structure-Based Design of First Ndc80 Loop-Targeting Peptide Disrupting Ndc80-Nuf2 Interaction for Hepatocellular Carcinoma Therapy. | J Med Chem | 2026 | 42720478 | PubTator, text mining | PubMed |
| Targeting the HEC1-NEK2 Axis Suppresses DLBCL Progression and Overcomes Vincristine Resistance. | Mol Cancer Ther | 2026 | 42708803 | PubTator, text mining | PubMed |
| Exploring the mechanism of Shengmai San in treating lung adenocarcinoma based on bioinformatics and molecular dynamics simulation. | Medicine (Baltimore) | 2026 | 42675738 | PubTator, text mining | PubMed |
| MicroRNA Signatures of Fulvestrant-Treated Luminal Breast Cancer Cells: Identification of Therapeutic Targets Regulated by miR-374b-5p. | Int J Mol Sci | 2026 | 42589442 | PubTator, text mining | PubMed |
| Bioinformatics and experimental studies of atherosclerosis-related endothelial dysfunction genes in renal calculi and exploration of their molecular mechanisms. | PLoS One | 2026 | 42550868 | PubTator, text mining | PubMed |
| NEK2 is essential for spindle assembly checkpoint regulation and cytoskeleton organization in porcine oocyte meiotic maturation. | Mol Cell Biochem | 2026 | 42550427 | PubTator, text mining | PubMed |
| A Review on Structural Insights into NLRP3 and NEK7: Domain Architecture, Subcellular Localization, and Their Interaction in Inflammasome Assembly and Signaling. | Mol Neurobiol | 2026 | 42550363 | PubTator, text mining | PubMed |
| Mitotic Hub Gene Network in Colorectal Cancer: Integrated Transcriptomic, Protein-Level, and Clinical-Genomic Characterization of a Ten-Gene Signature. | Genes (Basel) | 2026 | 42510823 | PubTator, text mining | PubMed |
| Transcriptomics-driven non-invasive liquid biopsy for diagnosing peritoneal lavage cytology-positive gastric cancer. | NPJ Precis Oncol | 2026 | 42457866 | PubTator, text mining | PubMed |
| Exploring the potential of gut microbiota metabolites in the treatment of endometriosis through network pharmacology and Mendelian randomization. | Front Microbiol | 2026 | 42369548 | PubTator, text mining | PubMed |
1 to 10 of 2,227
See all 2,227 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4751
GET https://conductscience.org/api/genes/v1/4751/patents?page=2