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Gene · 4751

NEK2: NIMA related kinase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NEK2: NIMA related kinase 2. Genes, record 4751. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4751

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Gene

Symbol
NEK2
HGNC
Name
NIMA related kinase 2
HGNC
NCBI Gene ID
4751
NCBI Gene
HGNC ID
HGNC:7745
HGNC
Ensembl
ENSG00000117650
NCBI Gene
Aliases
HsPK21, NEK2A, NLK1, PPP1R111, RP67
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P51955Serine/threonine-protein kinase Nek244530Ensembl, GeneID, HGNC

Source UniProt

Patents57

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-1947P51955Espacenet
JP 2026004568 A2026-01-1455744P51955Espacenet
EP 4641202 A22025-10-295376P51955Espacenet
JP 2025032204 A2025-03-1132233P51955Espacenet
KR 1020250017231 A2025-02-045376P51955Espacenet
EP 4461818 A22024-11-1332233P51955Espacenet
US 12130292 B22024-10-2930P51955Espacenet
WO 2024214081 A12024-10-1747P51955Espacenet
US 11892452 B22024-02-065P51955Espacenet
JP 2023058610 A2023-04-2532233P51955Espacenet

1 to 10 of 57

See all 57 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,164

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNEK2 papersNewest fiscal year
P30CA086862Cancer Center Support Grant182025
U54CA163071(1/2) Ponce Health Sciences University-Moffitt Cancer Center Partnership #82025
U54CA1630682/2 Ponce Health Sciences University-Moffitt Cancer Center Partnership72025
P30CA006927Comprehensive Cancer Center Program at Fox Chase62025
P30CA016672Cancer Center Support Grant62025
P30CA076292Moffitt Cancer Center Support Grant52025
T32HL007344Program in Hematology: Molecular & Cell Biology of Blood Cells52025
P30CA030199Cancer Center Support Grant (CCSG)42025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant42025
P30ES017885Michigan Center on Lifestage Environmental Exposures and Disease (M-LEEaD)42025

1 to 10 of 1,164Source NIH's project files

See all 1,164 nih grants

Papers2,227

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Structure-Based Design of First Ndc80 Loop-Targeting Peptide Disrupting Ndc80-Nuf2 Interaction for Hepatocellular Carcinoma Therapy.J Med Chem202642720478PubTator, text miningPubMed
Targeting the HEC1-NEK2 Axis Suppresses DLBCL Progression and Overcomes Vincristine Resistance.Mol Cancer Ther202642708803PubTator, text miningPubMed
Exploring the mechanism of Shengmai San in treating lung adenocarcinoma based on bioinformatics and molecular dynamics simulation.Medicine (Baltimore)202642675738PubTator, text miningPubMed
MicroRNA Signatures of Fulvestrant-Treated Luminal Breast Cancer Cells: Identification of Therapeutic Targets Regulated by miR-374b-5p.Int J Mol Sci202642589442PubTator, text miningPubMed
Bioinformatics and experimental studies of atherosclerosis-related endothelial dysfunction genes in renal calculi and exploration of their molecular mechanisms.PLoS One202642550868PubTator, text miningPubMed
NEK2 is essential for spindle assembly checkpoint regulation and cytoskeleton organization in porcine oocyte meiotic maturation.Mol Cell Biochem202642550427PubTator, text miningPubMed
A Review on Structural Insights into NLRP3 and NEK7: Domain Architecture, Subcellular Localization, and Their Interaction in Inflammasome Assembly and Signaling.Mol Neurobiol202642550363PubTator, text miningPubMed
Mitotic Hub Gene Network in Colorectal Cancer: Integrated Transcriptomic, Protein-Level, and Clinical-Genomic Characterization of a Ten-Gene Signature.Genes (Basel)202642510823PubTator, text miningPubMed
Transcriptomics-driven non-invasive liquid biopsy for diagnosing peritoneal lavage cytology-positive gastric cancer.NPJ Precis Oncol202642457866PubTator, text miningPubMed
Exploring the potential of gut microbiota metabolites in the treatment of endometriosis through network pharmacology and Mendelian randomization.Front Microbiol202642369548PubTator, text miningPubMed

1 to 10 of 2,227

See all 2,227 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4751

GET https://conductscience.org/api/genes/v1/4751/patents?page=2