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Gene · 476

ATP1A1: ATPase Na+/K+ transporting subunit alpha 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ATP1A1: ATPase Na+/K+ transporting subunit alpha 1. Genes, record 476. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/476

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Gene

Symbol
ATP1A1
HGNC
Name
ATPase Na+/K+ transporting subunit alpha 1
HGNC
NCBI Gene ID
476
NCBI Gene
HGNC ID
HGNC:799
HGNC
Ensembl
ENSG00000163399
NCBI Gene
Aliases
CMT2DD, HOMGSMR2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P05023Sodium/potassium-transporting ATPase subunit alpha-11,02313Ensembl, GeneID, HGNC

Source UniProt

Patents122

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1438313P05023Espacenet
EP 4650780 A22025-11-193628P05023Espacenet
EP 4641201 A22025-10-293223P05023Espacenet
JP 2025529142 A2025-09-04497P05023Espacenet
US 12371689 B22025-07-29497P05023Espacenet
EP 4572801 A12025-06-25310P05023Espacenet
EP 4572802 A12025-06-25310P05023Espacenet
EP 4572803 A12025-06-25310P05023Espacenet
JP 2025517969 A2025-06-123223P05023Espacenet
JP 2025517970 A2025-06-123628P05023Espacenet

1 to 10 of 122

See all 122 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACETYLDIGITOXINCHEMBL3545057Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
DESLANOSIDECHEMBL1614Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
DIGITOXINCHEMBL254219Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
DIGOXINCHEMBL1751Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
ISTAROXIMECHEMBL2093999Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
LANATOSIDE CCHEMBL506569Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL

Trials55

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants1,463

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleATP1A1 papersNewest fiscal year
U54GM115428Mississippi Center for Clinical and Translational Research172025
P30CA016672Cancer Center Support Grant82025
R01DK043140Mechanisms Leading to Adrenal Zonation82025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202872025
R01NS058949Clinical, Genetic, and Cellular Consequences of Mutations In NA,K-ATPase ATP1A372025
P30CA068485Cancer Center Support Grant52025
P30DK058404Molecular and Cellular Basis for Digestive Diseases42025
P30EY000331Vision Research Core at UCLA42025
R01DK062027Mechanisms of Adrenal Differentiation42025
UL1TR001863Yale Clinical and Translational Science Award42025

1 to 10 of 1,463Source NIH's project files

See all 1,463 nih grants

Papers2,080

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic Variants of Na+,K+-ATPase Associated With Neurological Disorders: A Systematic Review.Am J Med Genet B Neuropsychiatr Genet202642764777PubTator, text miningPubMed
Alignment of Micrometer-Scale Electrospun Fibers Does Not Enhance Performance of Primary Human Renal Proximal Tubular Epithelial Cells.J Biomed Mater Res B Appl Biomater202642693694PubTator, text miningPubMed
YAP-mediated mechanotransduction promotes hepatocellular carcinoma progression by targeting ATP1A1/CXCL1 axis.Acta Pharmacol Sin202642680799PubTator, text miningPubMed
A mechanistic evaluation of sodium channel modulators in hiPSC-derived cardiomyocytes using fluorescence-based sodium flux imaging.Biotechnol Lett202642678620PubTator, text miningPubMed
Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.J Precis Med (Amst)202642644057PubTator, text miningPubMed
Surface Proteomics of Cancer-Derived Extracellular Vesicles Reveals Universal Heat Shock Proteins and Cancer Signatures.Mol Cell Proteomics202642628842PubTator, text miningPubMed
ATP1A1 variants spring a leak.J Gen Physiol202642579713PubTator, text miningPubMed
[Primary aldosteronism as an independent factor of kidney damage. Potential therapeutic strategies and research prospects].Probl Endokrinol (Mosk)202642545319PubTator, text miningPubMed
The +57C>T substitution in microRNA-184 is associated with microphthalmia, retinal detachment, and altered ocular development.medRxiv202642428117PubTator, text miningPubMed
On the mechanism of hypomagnesemia with treatment-resistant seizures caused by variants of the Na+,K+-ATPase α1 subunit (ATP1A1).J Gen Physiol202642377349PubTator, text miningPubMed

1 to 10 of 2,080

See all 2,080 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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