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NF1: neurofibromin 1

1 protein, 38 patents, 0 drugs, 0 trials, 7,851 NIH grants and 24,469 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNF1HGNC
Nameneurofibromin 1HGNC
NCBI Gene ID4763NCBI Gene
HGNC IDHGNC:7765HGNC
EnsemblENSG00000196712NCBI Gene
AliasesNFNS, VRNF, WSSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P21359Neurofibromin2,83926Ensembl, GeneID, HGNCUniProt

Patents 38

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2025261963 A12025-12-2613P21359Espacenet
EP 4650780 A22025-11-197525P21359Espacenet
EP 4641201 A22025-10-297521P21359Espacenet
US 12433933 B22025-10-072P21359Espacenet
JP 2025529142 A2025-09-042828P21359Espacenet
US 12371689 B22025-07-292828P21359Espacenet
JP 2025517969 A2025-06-127521P21359Espacenet
JP 2025517970 A2025-06-127525P21359Espacenet
JP 2024123008 A2024-09-107300P21359Espacenet
JP 2023549761 A2023-11-29233P21359Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 7851

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant4052,025NIH's project files
P30CA016672Cancer Center Support Grant2072,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)962,025NIH's project files
P30CA006973Regional Oncology Research Center702,025NIH's project files
R01NS028840Mitogenic Activities in Neurofibromatosis572,025NIH's project files
U54CA196519Developmental and Hyperactive Ras Tumor (DHART) SPORE532,025NIH's project files
P30CA016058Cancer Center Support Grant492,025NIH's project files
P30CA086862Cancer Center Support Grant452,025NIH's project files
P30CA091842Cancer Center Support Grant402,025NIH's project files
P50CA097257Brain Tumor SPORE Grant352,025NIH's project files

Papers 24469

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827359PubTator, text miningPubMed
42826567PubTator, text miningPubMed
42826282PubTator, text miningPubMed
42820254PubTator, text miningPubMed
42820191PubTator, text miningPubMed
42818859PubTator, text miningPubMed
42816334PubTator, text miningPubMed
42814864PubTator, text miningPubMed
42814344PubTator, text miningPubMed
42809616PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license