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Gene · 477

ATP1A2: ATPase Na+/K+ transporting subunit alpha 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ATP1A2: ATPase Na+/K+ transporting subunit alpha 2. Genes, record 477. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/477

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Gene

Symbol
ATP1A2
HGNC
Name
ATPase Na+/K+ transporting subunit alpha 2
HGNC
NCBI Gene ID
477
NCBI Gene
HGNC ID
HGNC:800
HGNC
Ensembl
ENSG00000018625
NCBI Gene
Aliases
DEE98, FARIMPD, FHM2, MHP2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P50993Sodium/potassium-transporting ATPase subunit alpha-21,0200Ensembl, GeneID, HGNC

Source UniProt

Patents62

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1438321P50993Espacenet
EP 4641201 A22025-10-297971P50993Espacenet
JP 2025529142 A2025-09-04498P50993Espacenet
US 12371689 B22025-07-29498P50993Espacenet
JP 2025517969 A2025-06-127971P50993Espacenet
JP 2025062604 A2025-04-147539P50993Espacenet
US 12257313 B22025-03-2525P50993Espacenet
JP 2025032204 A2025-03-1124944P50993Espacenet
EP 4461818 A22024-11-1324944P50993Espacenet
US 11992527 B22024-05-2825P50993Espacenet

1 to 10 of 62

See all 62 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACETYLDIGITOXINCHEMBL3545057Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
DESLANOSIDECHEMBL1614Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
DIGITOXINCHEMBL254219Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
DIGOXINCHEMBL1751Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
ISTAROXIMECHEMBL2093999Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
LANATOSIDE CCHEMBL506569Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL

Trials55

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants773

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleATP1A2 papersNewest fiscal year
R01NS058949Clinical, Genetic, and Cellular Consequences of Mutations In NA,K-ATPase ATP1A362025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant22025
P50AA022537Cross-species investigation of gene networks for ethanol-related behaviors22025
R01AG055909Probing Heterogeneity of Alzheimer's Disease Using iPSCs22025
R01NS029709Excitability and Plasticity of Developing Epileptic Brain22025
R01NS106901Spreading Depolarizations and Neuronal Vulnerability22025
U24HG006673Systematic Exploration of the Human Interactome IV22025
U54GM115428Mississippi Center for Clinical and Translational Research22025
UL1TR001863Yale Clinical and Translational Science Award22025
ZIAAG007270ALZHEIMERS RESEARCH PROJECT: Genetic Markers of Brain Aging22025

1 to 10 of 773Source NIH's project files

See all 773 nih grants

Papers1,277

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrated RNA-seq and ATAC-seq analyses reveal muscle development differences between european meat pigeon and shiqi pigeon during embryonic to post-hatching stages.Front Cell Dev Biol202642780728PubTator, text miningPubMed
Genetic Variants of Na+,K+-ATPase Associated With Neurological Disorders: A Systematic Review.Am J Med Genet B Neuropsychiatr Genet202642764777PubTator, text miningPubMed
When Hemiplegic Migraine Defies Expectations: Diagnostic Complexity in a Rare Genetic Disorder.Case Rep Neurol202642633474PubTator, text miningPubMed
Single-Cell Proteomics Uncovers Cell-Specific Proteins in Vascular Health and Marfan Syndrome Disease-Brief Report.Arterioscler Thromb Vasc Biol202642592649PubTator, text miningPubMed
Identification of Copy Number Variations in Familial Hemiplegic Migraine Genes in Suspected Hemiplegic Migraine Patients.Biomedicines202642193281PubTator, text miningPubMed
[Genetics of primary headache disorders in children and adolescents].Ugeskr Laeger202642186880PubTator, text miningPubMed
[Hemiplegic migraine: from historical perspectives to current management].Rinsho Shinkeigaku202642178246PubTator, text miningPubMed
Dissociated neurovascular dynamics in ATP1A2-related familial hemiplegic migraine mimicking acute ischemic stroke.BMC Neurol202642115975PubTator, text miningPubMed
Machine learning-based prediction of Familial Hemiplegic Migraine risk from genetic variants.Comput Biol Med202642033889PubTator, text miningPubMed
Identification of case-specific copy number variants reveals novel genetic insights into familial hemiplegic migraine pathogenesis.Genomics202641951059PubTator, text miningPubMed

1 to 10 of 1,277

See all 1,277 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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The record and each of its lists are JSON, twenty rows a page. No key.

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