Gene · 477
ATP1A2: ATPase Na+/K+ transporting subunit alpha 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ATP1A2: ATPase Na+/K+ transporting subunit alpha 2. Genes, record 477. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/477
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P50993 | Sodium/potassium-transporting ATPase subunit alpha-2 | 1,020 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents62
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 38321 | P50993 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 7971 | P50993 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 498 | P50993 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 498 | P50993 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 7971 | P50993 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 7539 | P50993 | Espacenet |
| US 12257313 B2 | 2025-03-25 | 25 | P50993 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 24944 | P50993 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 24944 | P50993 | Espacenet |
| US 11992527 B2 | 2024-05-28 | 25 | P50993 | Espacenet |
1 to 10 of 62
See all 62 patentsDrugs6
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ACETYLDIGITOXIN | CHEMBL3545057 | Sodium/potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| DESLANOSIDE | CHEMBL1614 | Sodium/potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| DIGITOXIN | CHEMBL254219 | Sodium/potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| DIGOXIN | CHEMBL1751 | Sodium/potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| ISTAROXIME | CHEMBL2093999 | Sodium/potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| LANATOSIDE C | CHEMBL506569 | Sodium/potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
Trials55
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07272902 | DIGOXIN | ClinicalTrials.gov | ||
| NCT07047209 | DIGOXIN | PHASE2 | ClinicalTrials.gov | |
| NCT07025850 | DIGOXIN | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT06701812 | DIGOXIN | PHASE2 | ClinicalTrials.gov | |
| NCT06657404 | DIGOXIN | ClinicalTrials.gov | ||
| NCT06588699 | DIGOXIN | PHASE2 | ClinicalTrials.gov | |
| NCT06322017 | DIGOXIN | ClinicalTrials.gov | ||
| NCT06240403 | DIGOXIN | PHASE2 | ClinicalTrials.gov | |
| NCT06030622 | DIGOXIN | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT05975021 | ISTAROXIME | PHASE1/PHASE2 | ClinicalTrials.gov |
1 to 10 of 55
See all 55 trialsNIH grants773
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ATP1A2 papers | Newest fiscal year |
|---|---|---|---|
| R01NS058949 | Clinical, Genetic, and Cellular Consequences of Mutations In NA,K-ATPase ATP1A3 | 6 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 2 | 2025 |
| P50AA022537 | Cross-species investigation of gene networks for ethanol-related behaviors | 2 | 2025 |
| R01AG055909 | Probing Heterogeneity of Alzheimer's Disease Using iPSCs | 2 | 2025 |
| R01NS029709 | Excitability and Plasticity of Developing Epileptic Brain | 2 | 2025 |
| R01NS106901 | Spreading Depolarizations and Neuronal Vulnerability | 2 | 2025 |
| U24HG006673 | Systematic Exploration of the Human Interactome IV | 2 | 2025 |
| U54GM115428 | Mississippi Center for Clinical and Translational Research | 2 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 2 | 2025 |
| ZIAAG007270 | ALZHEIMERS RESEARCH PROJECT: Genetic Markers of Brain Aging | 2 | 2025 |
1 to 10 of 773Source NIH's project files
See all 773 nih grantsPapers1,277
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Integrated RNA-seq and ATAC-seq analyses reveal muscle development differences between european meat pigeon and shiqi pigeon during embryonic to post-hatching stages. | Front Cell Dev Biol | 2026 | 42780728 | PubTator, text mining | PubMed |
| Genetic Variants of Na+,K+-ATPase Associated With Neurological Disorders: A Systematic Review. | Am J Med Genet B Neuropsychiatr Genet | 2026 | 42764777 | PubTator, text mining | PubMed |
| When Hemiplegic Migraine Defies Expectations: Diagnostic Complexity in a Rare Genetic Disorder. | Case Rep Neurol | 2026 | 42633474 | PubTator, text mining | PubMed |
| Single-Cell Proteomics Uncovers Cell-Specific Proteins in Vascular Health and Marfan Syndrome Disease-Brief Report. | Arterioscler Thromb Vasc Biol | 2026 | 42592649 | PubTator, text mining | PubMed |
| Identification of Copy Number Variations in Familial Hemiplegic Migraine Genes in Suspected Hemiplegic Migraine Patients. | Biomedicines | 2026 | 42193281 | PubTator, text mining | PubMed |
| [Genetics of primary headache disorders in children and adolescents]. | Ugeskr Laeger | 2026 | 42186880 | PubTator, text mining | PubMed |
| [Hemiplegic migraine: from historical perspectives to current management]. | Rinsho Shinkeigaku | 2026 | 42178246 | PubTator, text mining | PubMed |
| Dissociated neurovascular dynamics in ATP1A2-related familial hemiplegic migraine mimicking acute ischemic stroke. | BMC Neurol | 2026 | 42115975 | PubTator, text mining | PubMed |
| Machine learning-based prediction of Familial Hemiplegic Migraine risk from genetic variants. | Comput Biol Med | 2026 | 42033889 | PubTator, text mining | PubMed |
| Identification of case-specific copy number variants reveals novel genetic insights into familial hemiplegic migraine pathogenesis. | Genomics | 2026 | 41951059 | PubTator, text mining | PubMed |
1 to 10 of 1,277
See all 1,277 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/477
GET https://conductscience.org/api/genes/v1/477/patents?page=2