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Gene · 4773

NFATC2: nuclear factor of activated T cells 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NFATC2: nuclear factor of activated T cells 2. Genes, record 4773. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4773

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Gene

Symbol
NFATC2
HGNC
Name
nuclear factor of activated T cells 2
HGNC
NCBI Gene ID
4773
NCBI Gene
HGNC ID
HGNC:7776
HGNC
Ensembl
ENSG00000101096
NCBI Gene
Aliases
JCOSL, NF-ATP, NFAT1, NFATP, NFATp
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13469Nuclear factor of activated T-cells, cytoplasmic 292512Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4641201 A22025-10-2911832Q13469Espacenet
JP 2025147176 A2025-10-0615361Q13469Espacenet
JP 2025517969 A2025-06-1211832Q13469Espacenet
JP 2025032204 A2025-03-1132312Q13469Espacenet
JP 2025028160 A2025-02-2815361Q13469Espacenet
KR 1020250010750 A2025-01-2115361Q13469Espacenet
EP 4461818 A22024-11-1332312Q13469Espacenet
JP 2024123008 A2024-09-107402Q13469Espacenet
JP 2024109657 A2024-08-1415200Q13469Espacenet
JP 2023058610 A2023-04-2532312Q13469Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,382

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNFATC2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant252025
R01AI040127Signal transduction and gene induction in lymphocytes122025
P30CA016672Cancer Center Support Grant112025
P30CA016056Roswell Park Cancer Center Support Grant82025
P50CA217694SPORE in Soft Tissue Sarcoma82025
P30CA046934University of Colorado Cancer Center Support Grant72025
P30DK084567Mayo Center for Cell Signaling in Gastroenterology62025
R35HL150778Ca2+ signaling Networks in Health and Disease62025
P30AI027763UCSF-Bay Area Center for AIDS Research52025
P30CA016058Cancer Center Support Grant52025

1 to 10 of 2,382Source NIH's project files

See all 2,382 nih grants

Papers3,204

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
NFAM1 organizes a lipid raft-restricted DAPP1-PLCG2 module to drive M2-like GAM polarization via Ca²⁺-NFAT1 signaling in glioma.Neuro Oncol202642820763PubTator, text miningPubMed
Harmine Hydrochloride from Peganum harmala L. Targets NFAT1 for Proteasomal Degradation to Suppress Ovarian Cancer Progression.Pharmaceuticals (Basel)202642797387PubTator, text miningPubMed
Palmitic Acid Inhibits the Proliferation and Hypertrophy of Antler Chondrocytes by Disrupting Mitochondria-Associated Endoplasmic Reticulum Membrane Function.Antioxidants (Basel)202642792147PubTator, text miningPubMed
Avicularin and Senegenin Suppress TRPV3-Associated TSLP Expression in Human Keratinocytes.Cells202642782759PubTator, text miningPubMed
POLE2 of tumor cells promotes OPN secretion based on PCLAF to drive M2 macrophage polarization in clear cell renal cell carcinoma.Cancer Gene Ther202642773249PubTator, text miningPubMed
Intracellular Ca2+ balances the anti-inflammatory potential of IL-33-activated mast cells (MCs).Cell Calcium202642753352PubTator, text miningPubMed
Investigation of psychosocial stress and DNA methylation in genes related to immune response, metabolism, and calcium signaling among African American and White middle-aged adults.Environ Epigenet202642698993PubTator, text miningPubMed
Integrative Multi-Omics Analysis Reveals Convergent Epigenome and Transcriptome Changes in Parkinson's Disease.Mov Disord202642610474PubTator, text miningPubMed
Non-redundant functions of NFATc1 in survival and NFATc2 in generation of exhausted CD8+ T cells.Front Immunol202642568576PubTator, text miningPubMed
Transposable elements and homotypic niches drive immune dynamics and resistance in melanoma epigenetic-based immunotherapy.Sci Adv202642566510PubTator, text miningPubMed

1 to 10 of 3,204

See all 3,204 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4773

GET https://conductscience.org/api/genes/v1/4773/patents?page=2