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Gene · 4778

NFE2: nuclear factor, erythroid 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NFE2: nuclear factor, erythroid 2. Genes, record 4778. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4778

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Gene

Symbol
NFE2
HGNC
Name
nuclear factor, erythroid 2
HGNC
NCBI Gene ID
4778
NCBI Gene
HGNC ID
HGNC:7780
HGNC
Ensembl
ENSG00000123405
NCBI Gene
Aliases
NF-E2, p45
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q16621Transcription factor NF-E2 45 kDa subunit3731Ensembl, GeneID, HGNC

Source UniProt

Patents49

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455964Q16621Espacenet
JP 2026004568 A2026-01-1455965Q16621Espacenet
JP 2026004568 A2026-01-1455966Q16621Espacenet
JP 2026004568 A2026-01-1455967Q16621Espacenet
JP 2025147176 A2025-10-0615364Q16621Espacenet
JP 2025028160 A2025-02-2815364Q16621Espacenet
KR 1020250010750 A2025-01-2115364Q16621Espacenet
JP 2024109657 A2024-08-1415203Q16621Espacenet
US 11446398 B22022-09-2058093Q16621Espacenet
US 11446398 B22022-09-2058094Q16621Espacenet

1 to 10 of 49

See all 49 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,534

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNFE2 papersNewest fiscal year
P01CA108671Myeloproliferative Neoplasms-Research Consortium172025
P30CA016672Cancer Center Support Grant92025
R01DK050107Transcriptional Control of Hemoglobin Synthesis and Erythrocyte Development92025
R01DK103794Systematic Genetic Dissection of Human Erythropoiesis82025
P30CA008748Cancer Center Support Grant72025
P30CA021765Cancer Center Support Grant (CCSG)62025
P30CA086862Cancer Center Support Grant62025
P30CA015704Cancer Center Support Grant52025
P30ES006694Southwest Environmental Health Sciences Center52025
K12HD000850Pediatric Scientist Development Program42025

1 to 10 of 1,534Source NIH's project files

See all 1,534 nih grants

Papers2,142

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Cell type-specific histone acetylation landscape in Alzheimer's disease reveals a putative role of MITF in microglia.bioRxiv202642779635PubTator, text miningPubMed
The placental maturation inflection point: an integrative biological framework for understanding early-onset versus late-onset preeclampsia.Front Endocrinol (Lausanne)202642745947PubTator, text miningPubMed
Computational insights into the regulatory role and functional significance of NOTCH1 intronic SNP rs3124599 and its link to NPC.Comput Biol Chem202642685632PubTator, text miningPubMed
The role and mechanism of diosgenin glucoside in modulating megakaryopoiesis through promotion of autophagy via the AMPK/mTOR/ULK1 signaling pathway.Int Immunopharmacol202642679530PubTator, text miningPubMed
The roles of RUNX1 in megakaryocyte differentiation in myeloid leukemia.Leuk Lymphoma202642636146PubTator, text miningPubMed
A novel role for transcription factor NFE2 in redox regulation and chemotherapy resistance in acute myeloid leukemia.Leukemia202642618699PubTator, text miningPubMed
TGF-β1 drives neutrophil extracellular traps formation to promote CD8+ T cell exhaustion via the ERK-c-Fos-JunB axis, mediating gastric cancer immunotherapy resistance.J Immunother Cancer202642552060PubTator, text miningPubMed
Multi-trait genetic analysis identifies novel pleiotropic loci for stroke and hematological traits or risk factors.Fundam Res202642539752PubTator, text miningPubMed
Cold exposure aggravates vein occlusion through non-shivering thermogenesis-induced thrombocytopoiesis.Cell Res202642533097PubTator, text miningPubMed
Splicing-mediated control of hnRNPD isoform switching by SRSF2 drives PD-L1-dependent immune evasion in gallbladder cancer.Oncogene202642477458PubTator, text miningPubMed

1 to 10 of 2,142

See all 2,142 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4778

GET https://conductscience.org/api/genes/v1/4778/patents?page=2