Gene · 4778
NFE2: nuclear factor, erythroid 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NFE2: nuclear factor, erythroid 2. Genes, record 4778. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4778
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q16621 | Transcription factor NF-E2 45 kDa subunit | 373 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents49
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 55964 | Q16621 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 55965 | Q16621 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 55966 | Q16621 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 55967 | Q16621 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15364 | Q16621 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15364 | Q16621 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15364 | Q16621 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15203 | Q16621 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 58093 | Q16621 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 58094 | Q16621 | Espacenet |
1 to 10 of 49
See all 49 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,534
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NFE2 papers | Newest fiscal year |
|---|---|---|---|
| P01CA108671 | Myeloproliferative Neoplasms-Research Consortium | 17 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 9 | 2025 |
| R01DK050107 | Transcriptional Control of Hemoglobin Synthesis and Erythrocyte Development | 9 | 2025 |
| R01DK103794 | Systematic Genetic Dissection of Human Erythropoiesis | 8 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 7 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 6 | 2025 |
| P30CA086862 | Cancer Center Support Grant | 6 | 2025 |
| P30CA015704 | Cancer Center Support Grant | 5 | 2025 |
| P30ES006694 | Southwest Environmental Health Sciences Center | 5 | 2025 |
| K12HD000850 | Pediatric Scientist Development Program | 4 | 2025 |
1 to 10 of 1,534Source NIH's project files
See all 1,534 nih grantsPapers2,142
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Cell type-specific histone acetylation landscape in Alzheimer's disease reveals a putative role of MITF in microglia. | bioRxiv | 2026 | 42779635 | PubTator, text mining | PubMed |
| The placental maturation inflection point: an integrative biological framework for understanding early-onset versus late-onset preeclampsia. | Front Endocrinol (Lausanne) | 2026 | 42745947 | PubTator, text mining | PubMed |
| Computational insights into the regulatory role and functional significance of NOTCH1 intronic SNP rs3124599 and its link to NPC. | Comput Biol Chem | 2026 | 42685632 | PubTator, text mining | PubMed |
| The role and mechanism of diosgenin glucoside in modulating megakaryopoiesis through promotion of autophagy via the AMPK/mTOR/ULK1 signaling pathway. | Int Immunopharmacol | 2026 | 42679530 | PubTator, text mining | PubMed |
| The roles of RUNX1 in megakaryocyte differentiation in myeloid leukemia. | Leuk Lymphoma | 2026 | 42636146 | PubTator, text mining | PubMed |
| A novel role for transcription factor NFE2 in redox regulation and chemotherapy resistance in acute myeloid leukemia. | Leukemia | 2026 | 42618699 | PubTator, text mining | PubMed |
| TGF-β1 drives neutrophil extracellular traps formation to promote CD8+ T cell exhaustion via the ERK-c-Fos-JunB axis, mediating gastric cancer immunotherapy resistance. | J Immunother Cancer | 2026 | 42552060 | PubTator, text mining | PubMed |
| Multi-trait genetic analysis identifies novel pleiotropic loci for stroke and hematological traits or risk factors. | Fundam Res | 2026 | 42539752 | PubTator, text mining | PubMed |
| Cold exposure aggravates vein occlusion through non-shivering thermogenesis-induced thrombocytopoiesis. | Cell Res | 2026 | 42533097 | PubTator, text mining | PubMed |
| Splicing-mediated control of hnRNPD isoform switching by SRSF2 drives PD-L1-dependent immune evasion in gallbladder cancer. | Oncogene | 2026 | 42477458 | PubTator, text mining | PubMed |
1 to 10 of 2,142
See all 2,142 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4778
GET https://conductscience.org/api/genes/v1/4778/patents?page=2