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Gene · 478

ATP1A3: ATPase Na+/K+ transporting subunit alpha 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ATP1A3: ATPase Na+/K+ transporting subunit alpha 3. Genes, record 478. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/478

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Gene

Symbol
ATP1A3
HGNC
Name
ATPase Na+/K+ transporting subunit alpha 3
HGNC
NCBI Gene ID
478
NCBI Gene
HGNC ID
HGNC:801
HGNC
Ensembl
ENSG00000105409
NCBI Gene
Aliases
AHC2, CAPOS, DEE99, DYT12, RDP
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P13637Sodium/potassium-transporting ATPase subunit alpha-31,0135Ensembl, GeneID, HGNC

Source UniProt

Patents48

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12533397 B22026-01-273P13637Espacenet
JP 2026004568 A2026-01-1438326P13637Espacenet
EP 4641201 A22025-10-2925521P13637Espacenet
JP 2025529142 A2025-09-04499P13637Espacenet
US 12371689 B22025-07-29499P13637Espacenet
JP 2025517969 A2025-06-1225521P13637Espacenet
JP 2025062604 A2025-04-147542P13637Espacenet
JP 2025032204 A2025-03-1124948P13637Espacenet
EP 4461818 A22024-11-1324948P13637Espacenet
JP 2023548973 A2023-11-21239P13637Espacenet

1 to 10 of 48

See all 48 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACETYLDIGITOXINCHEMBL3545057Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
DESLANOSIDECHEMBL1614Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
DIGITOXINCHEMBL254219Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
DIGOXINCHEMBL1751Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
ISTAROXIMECHEMBL2093999Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
LANATOSIDE CCHEMBL506569Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL

Trials55

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants656

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleATP1A3 papersNewest fiscal year
R01NS058949Clinical, Genetic, and Cellular Consequences of Mutations In NA,K-ATPase ATP1A3272025
P30CA068485Cancer Center Support Grant32025
R01AG067763Molecular characterization of extracellular vesicles for the spread of misfolded tau protein32025
UL1TR001863Yale Clinical and Translational Science Award32025
ZIANS002993Structure and Function of Membrane Proteins32025
P30AG066518Oregon Alzheimer's Disease Research Center22025
P30CA016672Cancer Center Support Grant22025
R01AG055909Probing Heterogeneity of Alzheimer's Disease Using iPSCs22025
R01AG072719Assessment of a novel tau propagation pathway from layer II medial entorhinal cortical neurons to CA1 pyramidal neurons as an early Braak stage mouse model22025
R01DC011805Imaging genetics of laryngeal dystonia22025

1 to 10 of 656Source NIH's project files

See all 656 nih grants

Papers1,199

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A De Novo ATP1A3 p.Arg995His Variant in a Patient With an Adult-Onset Primary Lateral Sclerosis-Like Syndrome.Clin Genet202642823832PubTator, text miningPubMed
Alternating Hemiplegia of Childhood: Development of a Disease-Specific Clinical Rating Scale.Neurol Genet202642813040PubTator, text miningPubMed
Scalable context-dependent single-cell eQTL mapping reveals disease-relevant regulatory variation beyond static models.medRxiv202642780159PubTator, text miningPubMed
Genetic Variants of Na+,K+-ATPase Associated With Neurological Disorders: A Systematic Review.Am J Med Genet B Neuropsychiatr Genet202642764777PubTator, text miningPubMed
Acute neuro-inflammatory presentation of ATP1A3 variants: Case reports of three patients with different phenotypes.Arch Pediatr202642763957PubTator, text miningPubMed
Monocular Nystagmus and Bulbar Dysfunction in Alternating Hemiplegia of Infantile Onset: A Novel Phenotype Associated with an ATP1A3 Mutation.Ann Indian Acad Neurol202642734471PubTator, text miningPubMed
Novel and Emerging Therapies for Childhood-Onset Movement Disorders.Mov Disord202642723627PubTator, text miningPubMed
Clinical and Genetic Spectrum of ATP1A3-Related Disorders: A Multicenter Cross-Sectional Study.Neurol Genet202642666683PubTator, text miningPubMed
[Clinical and genetic analysis of a child with Relapsing encephalopathy with cerebellar ataxia due to variant of ATP1A3 gene].Zhonghua Yi Xue Yi Chuan Xue Za Zhi202642386663PubTator, text miningPubMed
The genetic landscape of childhood-onset dystonia in a nationwide Turkish cohort: Clinical spectrum, molecular diagnostics, and therapeutic implications.Eur J Paediatr Neurol202642308683PubTator, text miningPubMed

1 to 10 of 1,199

See all 1,199 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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