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NFE2L2: NFE2 like bZIP transcription factor 2

1 protein, 82 patents, 2 drugs, 34 trials, 12,302 NIH grants and 52,796 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNFE2L2HGNC
NameNFE2 like bZIP transcription factor 2HGNC
NCBI Gene ID4780NCBI Gene
HGNC IDHGNC:7782HGNC
EnsemblENSG00000116044NCBI Gene
AliasesIMDDHH, NRF-2, NRF2, Nrf-2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q16236Nuclear factor erythroid 2-related factor 260523Ensembl, GeneID, HGNCUniProt

Patents 82

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455973Q16236Espacenet
JP 2025175073 A2025-11-281Q16236Espacenet
EP 4650780 A22025-11-1911446Q16236Espacenet
EP 4641201 A22025-10-2911986Q16236Espacenet
WO 2025213016 A22025-10-092Q16236Espacenet
JP 2025147176 A2025-10-0615366Q16236Espacenet
JP 2025134847 A2025-09-178Q16236Espacenet
JP 2025517969 A2025-06-1211986Q16236Espacenet
JP 2025517970 A2025-06-1211446Q16236Espacenet
JP 2025081326 A2025-05-2747Q16236Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
BARDOXOLONE METHYLCHEMBL1762621Keap1/Nrf2 inhibitorINHIBITORChEMBL
OMAVELOXOLONECHEMBL4303525Nuclear factor erythroid 2-related factor 2 activatorACTIVATORChEMBL

Trials 34

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07444333OMAVELOXOLONEClinicalTrials.gov
NCT07013292OMAVELOXOLONEClinicalTrials.gov
NCT06953583OMAVELOXOLONEPHASE3ClinicalTrials.gov
NCT06623890OMAVELOXOLONEClinicalTrials.gov
NCT06054893OMAVELOXOLONEPHASE1ClinicalTrials.gov
NCT04702997BARDOXOLONE METHYLPHASE22022-12-01ClinicalTrials.gov
NCT04494646BARDOXOLONE METHYLPHASE22022-01-12ClinicalTrials.gov
NCT04018339BARDOXOLONE METHYLPHASE1ClinicalTrials.gov
NCT03918447BARDOXOLONE METHYLPHASE32024-06-11ClinicalTrials.gov
NCT03749447BARDOXOLONE METHYLPHASE32024-03-19ClinicalTrials.gov

NIH grants 12302

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1282,025NIH's project files
P30ES006694Southwest Environmental Health Sciences Center1282,025NIH's project files
P30CA016672Cancer Center Support Grant1252,025NIH's project files
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)882,025NIH's project files
P40OD010440Caenorhabditis Genetics Center582,025NIH's project files
R01ES010563Mechanisms of Manganese Neurotoxicity492,025NIH's project files
T32ES007091Training in Environmental Toxicology of Human Disease472,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant462,025NIH's project files
R01ES007331Mechanisms of Methylmercury Induced Neuronal Toxicity452,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology422,025NIH's project files

Papers 52796

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42826872PubTator, text miningPubMed
42826199PubTator, text miningPubMed
42825885PubTator, text miningPubMed
42824186PubTator, text miningPubMed
42822613PubTator, text miningPubMed
42821792PubTator, text miningPubMed
42821452PubTator, text miningPubMed
42821430PubTator, text miningPubMed
42819625PubTator, text miningPubMed
42819418PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license