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NFKB1: nuclear factor kappa B subunit 1

1 protein, 68 patents, 1 drug, 4 trials, 51,622 NIH grants and 257,797 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNFKB1HGNC
Namenuclear factor kappa B subunit 1HGNC
NCBI Gene ID4790NCBI Gene
HGNC IDHGNC:7794HGNC
EnsemblENSG00000109320NCBI Gene
AliasesCVID12, EBP-1, KBF1, NF-kB, NF-kB1, NF-kappa-B1, NF-kappaB, NF-kappabeta, NFKB-p105, NFKB-p50, NFkappaB, p105, p50NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P19838Nuclear factor NF-kappa-B p105 subunit96815Ensembl, GeneID, HGNCUniProt

Patents 68

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12539325 B22026-02-0384P19838Espacenet
EP 4650780 A22025-11-1911190P19838Espacenet
EP 4641201 A22025-10-2911661P19838Espacenet
JP 2025147176 A2025-10-0615373P19838Espacenet
WO 2025177214 A12025-08-2815P19838Espacenet
JP 2025524002 A2025-07-2531P19838Espacenet
JP 2025517969 A2025-06-1211661P19838Espacenet
JP 2025517970 A2025-06-1211190P19838Espacenet
KR 1020250039465 A2025-03-2031P19838Espacenet
JP 2025028160 A2025-02-2815373P19838Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EDASALONEXENTCHEMBL3786673Nuclear factor NF-kappa-B complex inhibitorINHIBITORChEMBL

Trials 4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03917719EDASALONEXENTPHASE3ClinicalTrials.gov
NCT03703882EDASALONEXENTPHASE32022-06-21ClinicalTrials.gov
NCT02439216EDASALONEXENTPHASE1/PHASE22022-09-23ClinicalTrials.gov
NCT01511900EDASALONEXENTPHASE1ClinicalTrials.gov

NIH grants 51622

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant7852,025NIH's project files
P30CA008748Cancer Center Support Grant3692,025NIH's project files
P30CA016058Cancer Center Support Grant2132,025NIH's project files
P30CA068485Cancer Center Support Grant1552,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases1422,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award1402,025NIH's project files
P30CA016056Roswell Park Cancer Center Support Grant1262,025NIH's project files
P30CA047904Cancer Center Support Grant1262,025NIH's project files
P30ES001247Environmental Agents as Modulators of Disease Processes1122,025NIH's project files
P30DK043351Center for the Study of Inflammatory Bowel Disease at Massachusetts General Hospital1082,025NIH's project files

Papers 257797

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42827116PubTator, text miningPubMed
42826826PubTator, text miningPubMed
42826581PubTator, text miningPubMed
42826468PubTator, text miningPubMed
42826097PubTator, text miningPubMed
42826084PubTator, text miningPubMed
42825909PubTator, text miningPubMed
42825898PubTator, text miningPubMed
42825863PubTator, text miningPubMed
42825013PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license