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NFKB2: nuclear factor kappa B subunit 2

1 protein, 36 patents, 1 drug, 4 trials, 5,014 NIH grants and 7,641 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNFKB2HGNC
Namenuclear factor kappa B subunit 2HGNC
NCBI Gene ID4791NCBI Gene
HGNC IDHGNC:7795HGNC
EnsemblENSG00000077150NCBI Gene
AliasesCVID10, H2TF1, LYT-10, LYT10, NF-kB2, p100, p105, p49/p100, p52NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q00653Nuclear factor NF-kappa-B p100 subunit90011Ensembl, GeneID, HGNCUniProt

Patents 36

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-198696Q00653Espacenet
EP 4641201 A22025-10-298885Q00653Espacenet
EP 4641202 A22025-10-295478Q00653Espacenet
JP 2025147176 A2025-10-0615374Q00653Espacenet
WO 2025177214 A12025-08-2819Q00653Espacenet
JP 2025517969 A2025-06-128885Q00653Espacenet
JP 2025517970 A2025-06-128696Q00653Espacenet
JP 2025028160 A2025-02-2815374Q00653Espacenet
KR 1020250017231 A2025-02-045478Q00653Espacenet
KR 1020250010750 A2025-01-2115374Q00653Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
EDASALONEXENTCHEMBL3786673Nuclear factor NF-kappa-B complex inhibitorINHIBITORChEMBL

Trials 4

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT03917719EDASALONEXENTPHASE3ClinicalTrials.gov
NCT03703882EDASALONEXENTPHASE32022-06-21ClinicalTrials.gov
NCT02439216EDASALONEXENTPHASE1/PHASE22022-09-23ClinicalTrials.gov
NCT01511900EDASALONEXENTPHASE1ClinicalTrials.gov

NIH grants 5014

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant682,025NIH's project files
P30CA008748Cancer Center Support Grant202,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center142,025NIH's project files
P30CA006973Regional Oncology Research Center122,025NIH's project files
P30CA068485Cancer Center Support Grant122,025NIH's project files
P30AG017265USC/UCLA Center on Biodemography and Population Health112,025NIH's project files
UL1TR001866Developing, Demonstrating, and Disseminating Innovative Programs to Achieve Translational Success112,025NIH's project files
P30CA016087Cancer Center Support Grant102,025NIH's project files
P30CA016086Cancer Center Support Grant92,025NIH's project files
P30CA072720Cancer Center Support Grant92,025NIH's project files

Papers 7641

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818937PubTator, text miningPubMed
42792657PubTator, text miningPubMed
42786362PubTator, text miningPubMed
42725575PubTator, text miningPubMed
42625294PubTator, text miningPubMed
42564111PubTator, text miningPubMed
42526699PubTator, text miningPubMed
42516061PubTator, text miningPubMed
42467271PubTator, text miningPubMed
42458766PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license