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Gene · 48

ACO1: aconitase 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ACO1: aconitase 1. Genes, record 48. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/48

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Gene

Symbol
ACO1
HGNC
Name
aconitase 1
HGNC
NCBI Gene ID
48
NCBI Gene
HGNC ID
HGNC:117
HGNC
Ensembl
ENSG00000122729
NCBI Gene
Aliases
ACONS, HEL60, IREB1, IREBP, IREBP1, IRP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P21399Cytoplasmic aconitate hydratase8892Ensembl, GeneID, HGNC

Source UniProt

Patents36

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1436049P21399Espacenet
JP 2026004568 A2026-01-1436051P21399Espacenet
EP 4650780 A22025-11-194622P21399Espacenet
EP 4641201 A22025-10-294189P21399Espacenet
JP 2025517969 A2025-06-124189P21399Espacenet
JP 2025517970 A2025-06-124622P21399Espacenet
JP 2025062604 A2025-04-141393P21399Espacenet
JP 2025062604 A2025-04-141394P21399Espacenet
JP 2025062604 A2025-04-141395P21399Espacenet
JP 2022546675 A2022-11-071P21399Espacenet

1 to 10 of 36

See all 36 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,242

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleACO1 papersNewest fiscal year
ZIAHD001602Regulation Of Intracellular Iron Metabolism442025
ZIAHD008814Mammalian iron-sulfur cluster biogenesis272025
ZIABC011038Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase Gene92025
T32DK007665Metabolism and Nutrition Training Program82025
ZIABC011028Clinical Studies of the Molecular Genetic Basis of Kidney Cancer72025
P30CA008748Cancer Center Support Grant62025
P30CA016087Cancer Center Support Grant62025
ZIDBC011089Clinical Nursing and Data Management Core52025
P30CA062203Cancer Center Support Grant42025
P30CA086862Cancer Center Support Grant42025

1 to 10 of 1,242Source NIH's project files

See all 1,242 nih grants

Papers2,325

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Ebselen sensitizes multidrug-resistant cancer cells to doxorubicin by disrupting cellular redox homeostasis and inducing ferroptosis.Life Sci202642735785PubTator, text miningPubMed
Disruption of cellular iron homeostasis by SRPX2-IRP1 interaction aggravates renal fibrosis in chronic kidney disease.Cell Death Differ202642733101PubTator, text miningPubMed
Polyamines buffer labile iron to suppress ferroptosis.Cell202642600612PubTator, text miningPubMed
Astrocyte Subtype-Specific Expression of the Sodium-Coupled Citrate Transporter SLC13A5 and Citrate Metabolism Genes Across Alzheimer's Disease Pseudoprogression: A Single-Nucleus RNA Sequencing Analysis of the Human Middle Temporal Gyrus.
Curr Issues Mol Biol202642510931PubTator, text miningPubMed
Mitochondrial Dysfunction and Telomeric Shortening as Long-term Complications After COVID-19.Arch Bronconeumol202642342534PubTator, text miningPubMed
Astrocyte subtype-specific expression of the sodium-coupled citrate transporter SLC13A5 and citrate metabolism genes across Alzheimer's disease pseudoprogression: a single-nucleus RNA sequencing analysis of the human middle temporal gyrus.
bioRxiv202642327234PubTator, text miningPubMed
IRP1/ARID3A complex promotes pancreatic cancer chemoresistance by suppressing CYGB-related ferroptosis.Genes Dis202642290659PubTator, text miningPubMed
Ferroptosis-related gene EPAS1 suppresses breast cancer progression by inhibiting M2 macrophage polarization.Discov Oncol202642243557PubTator, text miningPubMed
PeMPK7 enhances poplar salt tolerance by coordinating phytohormone dynamics and activating an ethylene-ERF114 regulatory module.Plant Physiol Biochem202642139968PubTator, text miningPubMed
Iron: Regulation, redox homeostasis, and ferroptosis in cancer.Ferroptosis Oxid Stress202642099806PubTator, text miningPubMed

1 to 10 of 2,325

See all 2,325 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/48

GET https://conductscience.org/api/genes/v1/48/patents?page=2