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Gene · 480

ATP1A4: ATPase Na+/K+ transporting subunit alpha 4

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ATP1A4: ATPase Na+/K+ transporting subunit alpha 4. Genes, record 480. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/480

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Gene

Symbol
ATP1A4
HGNC
Name
ATPase Na+/K+ transporting subunit alpha 4
HGNC
NCBI Gene ID
480
NCBI Gene
HGNC ID
HGNC:14073
HGNC
Ensembl
ENSG00000132681
NCBI Gene
Aliases
ATP1AL2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13733Sodium/potassium-transporting ATPase subunit alpha-41,0291Ensembl, GeneID, HGNC

Source UniProt

Patents117

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1438333Q13733Espacenet
EP 4641201 A22025-10-298542Q13733Espacenet
JP 2025529142 A2025-09-04500Q13733Espacenet
US 12371689 B22025-07-29500Q13733Espacenet
EP 4572801 A12025-06-25314Q13733Espacenet
EP 4572802 A12025-06-25314Q13733Espacenet
EP 4572803 A12025-06-25314Q13733Espacenet
JP 2025517969 A2025-06-128542Q13733Espacenet
JP 2025062604 A2025-04-147548Q13733Espacenet
US 12257313 B22025-03-2527Q13733Espacenet

1 to 10 of 117

See all 117 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACETYLDIGITOXINCHEMBL3545057Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
DESLANOSIDECHEMBL1614Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
DIGITOXINCHEMBL254219Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
DIGOXINCHEMBL1751Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
ISTAROXIMECHEMBL2093999Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
LANATOSIDE CCHEMBL506569Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL

Trials55

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants142

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleATP1A4 papersNewest fiscal year
P01AG052350Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's Disease12025
P30AI027763UCSF-Bay Area Center for AIDS Research12025
P30CA013148Comprehensive Cancer Center Support Grant12025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant12025
P30CA142543UT Southwestern Medical Center Simmons Comprehensive Cancer Center12025
P30DK056350Nutrition Obesity Research Center (NORC)12025
P30EY005722Center Core Grant for Vision Research12025
P50AA022537Cross-species investigation of gene networks for ethanol-related behaviors12025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control12025
R01DK093501WNK-SPAK signaling in the Distal Nephron12025

1 to 10 of 142Source NIH's project files

See all 142 nih grants

Papers231

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Mineral-driven molecular signatures of energy metabolism underpin sperm motility in buffalo.Anim Reprod Sci202642612345PubTator, text miningPubMed
Biallelic Variants in ATP1A4 Are Associated with Oligoasthenoteratozoospermia and Male Infertility.Clin Genet202642381520PubTator, text miningPubMed
Distinct genetic architecture of coronary heart disease in dyslipidemia patients.BMC Med Genomics202642121140PubTator, text miningPubMed
Pathophysiological Roles of Two Intracellular P-Type ATPases: The Cancer-Associated Na+,K+-ATPase α3 Isoform and the Parkinson's Disease-Related ATP13A2.Int J Mol Sci202641751935PubTator, text miningPubMed
Parallel Erosion of a Testis-Specific Na+/K+ ATPase in Three Mammalian Lineages Sheds Light into the Evolution of Spermatozoa Energetics.Genome Biol Evol202641626717PubTator, text miningPubMed
scAMZI: attention-based deep autoencoder with zero-inflated layer for clustering scRNA-seq data.BMC Genomics202540197174PubTator, text miningPubMed
An in silico analysis of dicofol-induced neurotoxicity mechanisms in humans.Neurotoxicol Teratol202540169113PubTator, text miningPubMed
Whole Exome Sequencing Reveals Candidate Variants in Ion Channel Genes for Pelvic Muscle Dysfunction in Young Females with a Family History.Int Urogynecol J202539833541PubTator, text miningPubMed
Molecular Structure of the Na+,K+-ATPase α4β1 Isoform in Its Ouabain-Bound Conformation.Int J Mol Sci202439596464Swiss-Prot, curatedPubMed
ATP1A1 is a promising new target for melanoma treatment and can be inhibited by its physiological ligand bufalin to restore targeted therapy efficacy.Cancer Cell Int202438178183PubTator, text miningPubMed

1 to 10 of 231

See all 231 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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