Gene · 480
ATP1A4: ATPase Na+/K+ transporting subunit alpha 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ATP1A4: ATPase Na+/K+ transporting subunit alpha 4. Genes, record 480. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/480
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q13733 | Sodium/potassium-transporting ATPase subunit alpha-4 | 1,029 | 1 | Ensembl, GeneID, HGNC |
Source UniProt
Patents117
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 38333 | Q13733 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8542 | Q13733 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 500 | Q13733 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 500 | Q13733 | Espacenet |
| EP 4572801 A1 | 2025-06-25 | 314 | Q13733 | Espacenet |
| EP 4572802 A1 | 2025-06-25 | 314 | Q13733 | Espacenet |
| EP 4572803 A1 | 2025-06-25 | 314 | Q13733 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8542 | Q13733 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 7548 | Q13733 | Espacenet |
| US 12257313 B2 | 2025-03-25 | 27 | Q13733 | Espacenet |
1 to 10 of 117
See all 117 patentsDrugs6
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action | Source |
|---|---|---|---|---|
| ACETYLDIGITOXIN | CHEMBL3545057 | Sodium/potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| DESLANOSIDE | CHEMBL1614 | Sodium/potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| DIGITOXIN | CHEMBL254219 | Sodium/potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| DIGOXIN | CHEMBL1751 | Sodium/potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| ISTAROXIME | CHEMBL2093999 | Sodium/potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
| LANATOSIDE C | CHEMBL506569 | Sodium/potassium-transporting ATPase inhibitor | INHIBITOR | ChEMBL |
Trials55
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT07272902 | DIGOXIN | ClinicalTrials.gov | ||
| NCT07047209 | DIGOXIN | PHASE2 | ClinicalTrials.gov | |
| NCT07025850 | DIGOXIN | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT06701812 | DIGOXIN | PHASE2 | ClinicalTrials.gov | |
| NCT06657404 | DIGOXIN | ClinicalTrials.gov | ||
| NCT06588699 | DIGOXIN | PHASE2 | ClinicalTrials.gov | |
| NCT06322017 | DIGOXIN | ClinicalTrials.gov | ||
| NCT06240403 | DIGOXIN | PHASE2 | ClinicalTrials.gov | |
| NCT06030622 | DIGOXIN | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT05975021 | ISTAROXIME | PHASE1/PHASE2 | ClinicalTrials.gov |
1 to 10 of 55
See all 55 trialsNIH grants142
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ATP1A4 papers | Newest fiscal year |
|---|---|---|---|
| P01AG052350 | Vascular Contributions to Dementia and Genetic Risk Factors for Alzheimer's Disease | 1 | 2025 |
| P30AI027763 | UCSF-Bay Area Center for AIDS Research | 1 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 1 | 2025 |
| P30CA138313 | Medical University of South Carolina - Cancer Center Support Grant | 1 | 2025 |
| P30CA142543 | UT Southwestern Medical Center Simmons Comprehensive Cancer Center | 1 | 2025 |
| P30DK056350 | Nutrition Obesity Research Center (NORC) | 1 | 2025 |
| P30EY005722 | Center Core Grant for Vision Research | 1 | 2025 |
| P50AA022537 | Cross-species investigation of gene networks for ethanol-related behaviors | 1 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 1 | 2025 |
| R01DK093501 | WNK-SPAK signaling in the Distal Nephron | 1 | 2025 |
1 to 10 of 142Source NIH's project files
See all 142 nih grantsPapers231
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Mineral-driven molecular signatures of energy metabolism underpin sperm motility in buffalo. | Anim Reprod Sci | 2026 | 42612345 | PubTator, text mining | PubMed |
| Biallelic Variants in ATP1A4 Are Associated with Oligoasthenoteratozoospermia and Male Infertility. | Clin Genet | 2026 | 42381520 | PubTator, text mining | PubMed |
| Distinct genetic architecture of coronary heart disease in dyslipidemia patients. | BMC Med Genomics | 2026 | 42121140 | PubTator, text mining | PubMed |
| Pathophysiological Roles of Two Intracellular P-Type ATPases: The Cancer-Associated Na+,K+-ATPase α3 Isoform and the Parkinson's Disease-Related ATP13A2. | Int J Mol Sci | 2026 | 41751935 | PubTator, text mining | PubMed |
| Parallel Erosion of a Testis-Specific Na+/K+ ATPase in Three Mammalian Lineages Sheds Light into the Evolution of Spermatozoa Energetics. | Genome Biol Evol | 2026 | 41626717 | PubTator, text mining | PubMed |
| scAMZI: attention-based deep autoencoder with zero-inflated layer for clustering scRNA-seq data. | BMC Genomics | 2025 | 40197174 | PubTator, text mining | PubMed |
| An in silico analysis of dicofol-induced neurotoxicity mechanisms in humans. | Neurotoxicol Teratol | 2025 | 40169113 | PubTator, text mining | PubMed |
| Whole Exome Sequencing Reveals Candidate Variants in Ion Channel Genes for Pelvic Muscle Dysfunction in Young Females with a Family History. | Int Urogynecol J | 2025 | 39833541 | PubTator, text mining | PubMed |
| Molecular Structure of the Na+,K+-ATPase α4β1 Isoform in Its Ouabain-Bound Conformation. | Int J Mol Sci | 2024 | 39596464 | Swiss-Prot, curated | PubMed |
| ATP1A1 is a promising new target for melanoma treatment and can be inhibited by its physiological ligand bufalin to restore targeted therapy efficacy. | Cancer Cell Int | 2024 | 38178183 | PubTator, text mining | PubMed |
1 to 10 of 231
See all 231 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/480
GET https://conductscience.org/api/genes/v1/480/patents?page=2