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Gene · 4821

NKX2-2: NK2 homeobox 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NKX2-2: NK2 homeobox 2. Genes, record 4821. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4821

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Gene

Symbol
NKX2-2
HGNC
Name
NK2 homeobox 2
HGNC
NCBI Gene ID
4821
NCBI Gene
HGNC ID
HGNC:7835
HGNC
Ensembl
ENSG00000125820
NCBI Gene
Aliases
NKX2.2, NKX2B
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
O95096Homeobox protein Nkx-2.22730Ensembl, GeneID, HGNC

Source UniProt

Patents33

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026048797 A2026-03-0546O95096Espacenet
JP 2026004568 A2026-01-1455806O95096Espacenet
EP 4641201 A22025-10-2910145O95096Espacenet
JP 2025147176 A2025-10-0615393O95096Espacenet
JP 2025517969 A2025-06-1210145O95096Espacenet
JP 2025032204 A2025-03-1132400O95096Espacenet
JP 2025028160 A2025-02-2815393O95096Espacenet
KR 1020250010750 A2025-01-2115393O95096Espacenet
EP 4461818 A22024-11-1332400O95096Espacenet
JP 2024109657 A2024-08-1415232O95096Espacenet

1 to 10 of 33

See all 33 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,452

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNKX2-2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant242025
P30DK020593Vanderbilt Diabetes Research Center172025
R01DK082590Regulation of pancreatic islet cell fate172025
P30DK019525University of Pennsylvania Diabetes Research Center102025
P30CA042014Cancer Center Support Grant92025
P30DK020579Diabetes Research Center92025
P30DK020595Diabetes Research and Training Center92025
R01DK114233Studying the Role of the Microenvironment on Differentiation and Maturation of Beta Cells82025
P30CA068485Cancer Center Support Grant72025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)72025

1 to 10 of 1,452Source NIH's project files

See all 1,452 nih grants

Papers1,860

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
A Spinal Cord Sarcoma With EWSR1::WT1 Fusion Exhibited Ewing Sarcoma-Like Pattern Rather Than Desmoplastic Small Round Cell Tumor.Pathol Int202642801529PubTator, text miningPubMed
Case Report: A report of two cases and literature review: primary pulmonary Ewing sarcoma presenting with hemoptysis and back pain.Front Oncol202642698478PubTator, text miningPubMed
Integrated Immunotherapy Target Atlas for Ewing Sarcoma.Cancer Genomics Proteomics202642674817PubTator, text miningPubMed
Presumptive Ewing Sarcoma of the Jejunum Presenting with Metastatic Disease: A Case Report and Focused Narrative Review.Int Med Case Rep J202642666438PubTator, text miningPubMed
Primary Ewing Sarcoma of the Lung: Integrative Analysis of Clinical, Histopathological, Immunohistochemical, and Cytogenetic Features with Literature Review.Indian J Surg Oncol202642661826PubTator, text miningPubMed
Recurrent Mandibular Ewing sarcoma in an 11-year-old boy: a rare pediatric case and review of the literature.J Med Case Rep202642618937PubTator, text miningPubMed
In vitro evaluation of microfluidic WS6-loaded Eudragit nanoparticles for improving insulin-producing cell differentiation.PLoS One202642550869PubTator, text miningPubMed
An Incidental EWSR1-Rearranged Sarcoma of the Orbit with Primitive Neuroectodermal Morphology and Myogenic Differentiation: A Case Report and Diagnostic Challenge".Asian J Neurosurg202642535165PubTator, text miningPubMed
Converging Signaling Networks Drive Taste Bud Morphogenesis, Turnover, and Regeneration.Int J Mol Sci202642449922PubTator, text miningPubMed
Role of Nkx2.2 immunohistochemistry in distinguishing Ewing sarcoma from neuroendocrine neoplasms at different sites.J Taibah Univ Med Sci202642394857PubTator, text miningPubMed

1 to 10 of 1,860

See all 1,860 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4821

GET https://conductscience.org/api/genes/v1/4821/patents?page=2