Gene · 4821
NKX2-2: NK2 homeobox 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NKX2-2: NK2 homeobox 2. Genes, record 4821. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4821
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| O95096 | Homeobox protein Nkx-2.2 | 273 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents33
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| WO 2026048797 A | 2026-03-05 | 46 | O95096 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 55806 | O95096 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 10145 | O95096 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15393 | O95096 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 10145 | O95096 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 32400 | O95096 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15393 | O95096 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15393 | O95096 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 32400 | O95096 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15232 | O95096 | Espacenet |
1 to 10 of 33
See all 33 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,452
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NKX2-2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 24 | 2025 |
| P30DK020593 | Vanderbilt Diabetes Research Center | 17 | 2025 |
| R01DK082590 | Regulation of pancreatic islet cell fate | 17 | 2025 |
| P30DK019525 | University of Pennsylvania Diabetes Research Center | 10 | 2025 |
| P30CA042014 | Cancer Center Support Grant | 9 | 2025 |
| P30DK020579 | Diabetes Research Center | 9 | 2025 |
| P30DK020595 | Diabetes Research and Training Center | 9 | 2025 |
| R01DK114233 | Studying the Role of the Microenvironment on Differentiation and Maturation of Beta Cells | 8 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 7 | 2025 |
| P30DK020541 | NYR-Diabetes Research Center (NYR-DRC) | 7 | 2025 |
1 to 10 of 1,452Source NIH's project files
See all 1,452 nih grantsPapers1,860
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| A Spinal Cord Sarcoma With EWSR1::WT1 Fusion Exhibited Ewing Sarcoma-Like Pattern Rather Than Desmoplastic Small Round Cell Tumor. | Pathol Int | 2026 | 42801529 | PubTator, text mining | PubMed |
| Case Report: A report of two cases and literature review: primary pulmonary Ewing sarcoma presenting with hemoptysis and back pain. | Front Oncol | 2026 | 42698478 | PubTator, text mining | PubMed |
| Integrated Immunotherapy Target Atlas for Ewing Sarcoma. | Cancer Genomics Proteomics | 2026 | 42674817 | PubTator, text mining | PubMed |
| Presumptive Ewing Sarcoma of the Jejunum Presenting with Metastatic Disease: A Case Report and Focused Narrative Review. | Int Med Case Rep J | 2026 | 42666438 | PubTator, text mining | PubMed |
| Primary Ewing Sarcoma of the Lung: Integrative Analysis of Clinical, Histopathological, Immunohistochemical, and Cytogenetic Features with Literature Review. | Indian J Surg Oncol | 2026 | 42661826 | PubTator, text mining | PubMed |
| Recurrent Mandibular Ewing sarcoma in an 11-year-old boy: a rare pediatric case and review of the literature. | J Med Case Rep | 2026 | 42618937 | PubTator, text mining | PubMed |
| In vitro evaluation of microfluidic WS6-loaded Eudragit nanoparticles for improving insulin-producing cell differentiation. | PLoS One | 2026 | 42550869 | PubTator, text mining | PubMed |
| An Incidental EWSR1-Rearranged Sarcoma of the Orbit with Primitive Neuroectodermal Morphology and Myogenic Differentiation: A Case Report and Diagnostic Challenge". | Asian J Neurosurg | 2026 | 42535165 | PubTator, text mining | PubMed |
| Converging Signaling Networks Drive Taste Bud Morphogenesis, Turnover, and Regeneration. | Int J Mol Sci | 2026 | 42449922 | PubTator, text mining | PubMed |
| Role of Nkx2.2 immunohistochemistry in distinguishing Ewing sarcoma from neuroendocrine neoplasms at different sites. | J Taibah Univ Med Sci | 2026 | 42394857 | PubTator, text mining | PubMed |
1 to 10 of 1,860
See all 1,860 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4821
GET https://conductscience.org/api/genes/v1/4821/patents?page=2