Gene · 4825
NKX6-1: NK6 homeobox 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NKX6-1: NK6 homeobox 1. Genes, record 4825. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4825
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P78426 | Homeobox protein Nkx-6.1 | 367 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents38
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4810598 A2 | 2026-09-23 | 6 | P78426 | Espacenet |
| EP 4771163 A1 | 2026-07-08 | 9 | P78426 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 3256 | P78426 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15401 | P78426 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 3256 | P78426 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15401 | P78426 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15401 | P78426 | Espacenet |
| US 12195756 B2 | 2025-01-14 | 6 | P78426 | Espacenet |
| JP 2024128028 A | 2024-09-20 | 35 | P78426 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15240 | P78426 | Espacenet |
1 to 10 of 38
See all 38 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,218
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NKX6-1 papers | Newest fiscal year |
|---|---|---|---|
| P30DK020593 | Vanderbilt Diabetes Research Center | 31 | 2025 |
| P30DK019525 | University of Pennsylvania Diabetes Research Center | 15 | 2025 |
| R01DK090570 | Defining the role of MafA in islet beta cells | 15 | 2025 |
| P30DK020579 | Diabetes Research Center | 13 | 2025 |
| R01DK114233 | Studying the Role of the Microenvironment on Differentiation and Maturation of Beta Cells | 13 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 12 | 2025 |
| P30DK020541 | NYR-Diabetes Research Center (NYR-DRC) | 12 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 11 | 2025 |
| P30DK036836 | Diabetes Research Center | 11 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 10 | 2025 |
1 to 10 of 1,218Source NIH's project files
See all 1,218 nih grantsPapers1,704
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Harmine selectively enhances human beta cell identity markers and function via protein kinase A pathways. | Diabetologia | 2026 | 42766004 | PubTator, text mining | PubMed |
| Protamine gene expression is associated with sperm motility in rams: An integrative experimental and gene network analysis. | Anim Reprod Sci | 2026 | 42748838 | PubTator, text mining | PubMed |
| Physical and Biochemical Determinants of Endocrine Fate in 3D Suspension Culture Based Stem Cell-Derived β-Cell Differentiation. | Cells | 2026 | 42738894 | PubTator, text mining | PubMed |
| MAFB in Pancreatic β-Cell Development and Dysfunction: Implications for Diabetes and Translational Applications. | Biomolecules | 2026 | 42650744 | PubTator, text mining | PubMed |
| Polystyrene Nanoplastics Drive β-Cell Dedifferentiation Through Dendritic Cell-Intrinsic MHC-I-Dependent Inflammatory Crosstalk. | Adv Sci (Weinh) | 2026 | 42605967 | PubTator, text mining | PubMed |
| In vitro evaluation of microfluidic WS6-loaded Eudragit nanoparticles for improving insulin-producing cell differentiation. | PLoS One | 2026 | 42550869 | PubTator, text mining | PubMed |
| A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth. | Cell Rep | 2026 | 42201810 | PubTator, text mining | PubMed |
| Mitochondrial development and remodeling occur at pancreatic progenitor stage during induction of stem cell-derived islet organoids. | Front Endocrinol (Lausanne) | 2026 | 42109718 | PubTator, text mining | PubMed |
| A loss of function variant in SLC30A8/ZnT8 drives proteomic changes associated with lowered apoptosis in human stem cell-derived islets. | medRxiv | 2026 | 42078397 | PubTator, text mining | PubMed |
| Optimal Protocol for Differentiation of Human Tonsil-Derived Mesenchymal Stem Cells into Pancreatic β-like Cells. | Tissue Eng Regen Med | 2026 | 42018227 | PubTator, text mining | PubMed |
1 to 10 of 1,704
See all 1,704 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4825
GET https://conductscience.org/api/genes/v1/4825/patents?page=2