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Gene · 4825

NKX6-1: NK6 homeobox 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NKX6-1: NK6 homeobox 1. Genes, record 4825. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4825

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Gene

Symbol
NKX6-1
HGNC
Name
NK6 homeobox 1
HGNC
NCBI Gene ID
4825
NCBI Gene
HGNC ID
HGNC:7839
HGNC
Ensembl
ENSG00000163623
NCBI Gene
Aliases
NKX6.1, NKX6A, Nkx6.1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P78426Homeobox protein Nkx-6.13670Ensembl, GeneID, HGNC

Source UniProt

Patents38

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4810598 A22026-09-236P78426Espacenet
EP 4771163 A12026-07-089P78426Espacenet
EP 4641201 A22025-10-293256P78426Espacenet
JP 2025147176 A2025-10-0615401P78426Espacenet
JP 2025517969 A2025-06-123256P78426Espacenet
JP 2025028160 A2025-02-2815401P78426Espacenet
KR 1020250010750 A2025-01-2115401P78426Espacenet
US 12195756 B22025-01-146P78426Espacenet
JP 2024128028 A2024-09-2035P78426Espacenet
JP 2024109657 A2024-08-1415240P78426Espacenet

1 to 10 of 38

See all 38 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,218

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNKX6-1 papersNewest fiscal year
P30DK020593Vanderbilt Diabetes Research Center312025
P30DK019525University of Pennsylvania Diabetes Research Center152025
R01DK090570Defining the role of MafA in islet beta cells152025
P30DK020579Diabetes Research Center132025
R01DK114233Studying the Role of the Microenvironment on Differentiation and Maturation of Beta Cells132025
P30CA008748Cancer Center Support Grant122025
P30DK020541NYR-Diabetes Research Center (NYR-DRC)122025
P30CA068485Cancer Center Support Grant112025
P30DK036836Diabetes Research Center112025
P30DK020572Michigan Diabetes Research Center (MDRC)102025

1 to 10 of 1,218Source NIH's project files

See all 1,218 nih grants

Papers1,704

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Harmine selectively enhances human beta cell identity markers and function via protein kinase A pathways.Diabetologia202642766004PubTator, text miningPubMed
Protamine gene expression is associated with sperm motility in rams: An integrative experimental and gene network analysis.Anim Reprod Sci202642748838PubTator, text miningPubMed
Physical and Biochemical Determinants of Endocrine Fate in 3D Suspension Culture Based Stem Cell-Derived β-Cell Differentiation.Cells202642738894PubTator, text miningPubMed
MAFB in Pancreatic β-Cell Development and Dysfunction: Implications for Diabetes and Translational Applications.Biomolecules202642650744PubTator, text miningPubMed
Polystyrene Nanoplastics Drive β-Cell Dedifferentiation Through Dendritic Cell-Intrinsic MHC-I-Dependent Inflammatory Crosstalk.Adv Sci (Weinh)202642605967PubTator, text miningPubMed
In vitro evaluation of microfluidic WS6-loaded Eudragit nanoparticles for improving insulin-producing cell differentiation.PLoS One202642550869PubTator, text miningPubMed
A human corticospinal organoid-slice connectoid model informs enhancer strategies for post-injury axon regrowth.Cell Rep202642201810PubTator, text miningPubMed
Mitochondrial development and remodeling occur at pancreatic progenitor stage during induction of stem cell-derived islet organoids.Front Endocrinol (Lausanne)202642109718PubTator, text miningPubMed
A loss of function variant in SLC30A8/ZnT8 drives proteomic changes associated with lowered apoptosis in human stem cell-derived islets.medRxiv202642078397PubTator, text miningPubMed
Optimal Protocol for Differentiation of Human Tonsil-Derived Mesenchymal Stem Cells into Pancreatic β-like Cells.Tissue Eng Regen Med202642018227PubTator, text miningPubMed

1 to 10 of 1,704

See all 1,704 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4825

GET https://conductscience.org/api/genes/v1/4825/patents?page=2