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Gene · 4837

NNMT: nicotinamide N-methyltransferase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NNMT: nicotinamide N-methyltransferase. Genes, record 4837. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4837

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Gene

Symbol
NNMT
HGNC
Name
nicotinamide N-methyltransferase
HGNC
NCBI Gene ID
4837
NCBI Gene
HGNC ID
HGNC:7861
HGNC
Ensembl
ENSG00000166741
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P40261Nicotinamide N-methyltransferase26433Ensembl, GeneID, HGNC

Source UniProt

Patents74

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455685P40261Espacenet
JP 2026004568 A2026-01-1455686P40261Espacenet
EP 4650780 A22025-11-193969P40261Espacenet
JP 2025517970 A2025-06-123969P40261Espacenet
US 11446398 B22022-09-2056865P40261Espacenet
US 11446398 B22022-09-2056866P40261Espacenet
JP 2022524081 A2022-04-27159836P40261Espacenet
JP 2022524081 A2022-04-27159837P40261Espacenet
JP 2021143843 A2021-09-24144P40261Espacenet
US 11078247 B22021-08-037560P40261Espacenet

1 to 10 of 74

See all 74 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants854

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNNMT papersNewest fiscal year
R35GM118112Chemical probes to decipher PAD biology72025
P30CA023168Cancer Center Support Grant62025
P30CA015083Mayo Clinic Comprehensive Cancer Center Support Grant52025
P30AG024832UTMB Claude D. Pepper Older Americans Independence Center42025
P30CA008748Cancer Center Support Grant32025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant32025
P30DK020572Michigan Diabetes Research Center (MDRC)32025
R01GM117275Protein N-terminal Methylation Mechanisms and Inhibition32025
P30CA014089University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG)22025
P30CA014599Cancer Center Support Grant22025

1 to 10 of 854Source NIH's project files

See all 854 nih grants

Papers1,489

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Nicotinamide N-methyltransferase deficiency disrupts endometrial decidualization partly through dysregulated H3K27 trimethylation in recurrent implantation failure.Mol Cell Endocrinol202742705148PubTator, text miningPubMed
Statement of retraction: Effect of nicotinamide N-methyltransferase on lipid accumulation in 3T3-L1 adipocytes.Bioengineered202642821468PubTator, text miningPubMed
Targeting nicotinamide metabolism to reprogram the tumor microenvironment: Mechanisms and novel therapeutic strategies.Crit Rev Oncol Hematol202642800593PubTator, text miningPubMed
Nicotinamide N-methyltransferase in tumor stroma-immune crosstalk: Metabolic-epigenetic mechanisms and translational opportunities.Int Immunopharmacol202642772041PubTator, text miningPubMed
Characterizing the Transcriptional Features That Underlie Established Injury and Disease Progression in Diabetic Kidney Disease.Kidney360202642747892PubTator, text miningPubMed
NNMT-associated metabolic-thromboinflammatory-immune co-activation in heterogeneous CTC clusters: a hypothesis-generating computational framework".BMC Cancer202642723032PubTator, text miningPubMed
Metabolic-epigenetic vulnerability in cardiometabolic HFpEF: One-carbon metabolism, DNMT maintenance, and methylation instability.Pharmacol Res202642624311PubTator, text miningPubMed
When muscles matter in SORD neuropathy.J Neuropathol Exp Neurol202642616755PubTator, text miningPubMed
Multi-omics analysis identifies a hepatocyte-associated signature in alcohol-related liver injury.Front Immunol202642558149PubTator, text miningPubMed
NNMT Loss Drives Cancer Progression by enhancing SAM availability for mTORC1 Signaling and Chromatin Methylation.bioRxiv202642553046PubTator, text miningPubMed

1 to 10 of 1,489

See all 1,489 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4837

GET https://conductscience.org/api/genes/v1/4837/patents?page=2