Gene · 4837
NNMT: nicotinamide N-methyltransferase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NNMT: nicotinamide N-methyltransferase. Genes, record 4837. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4837
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P40261 | Nicotinamide N-methyltransferase | 264 | 33 | Ensembl, GeneID, HGNC |
Source UniProt
Patents74
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 55685 | P40261 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 55686 | P40261 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 3969 | P40261 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 3969 | P40261 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 56865 | P40261 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 56866 | P40261 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 159836 | P40261 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 159837 | P40261 | Espacenet |
| JP 2021143843 A | 2021-09-24 | 144 | P40261 | Espacenet |
| US 11078247 B2 | 2021-08-03 | 7560 | P40261 | Espacenet |
1 to 10 of 74
See all 74 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants854
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NNMT papers | Newest fiscal year |
|---|---|---|---|
| R35GM118112 | Chemical probes to decipher PAD biology | 7 | 2025 |
| P30CA023168 | Cancer Center Support Grant | 6 | 2025 |
| P30CA015083 | Mayo Clinic Comprehensive Cancer Center Support Grant | 5 | 2025 |
| P30AG024832 | UTMB Claude D. Pepper Older Americans Independence Center | 4 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 3 | 2025 |
| P30CA125123 | Baylor College of Medicine Cancer Center - Cancer Center Support Grant | 3 | 2025 |
| P30DK020572 | Michigan Diabetes Research Center (MDRC) | 3 | 2025 |
| R01GM117275 | Protein N-terminal Methylation Mechanisms and Inhibition | 3 | 2025 |
| P30CA014089 | University of Southern California Norris Comprehensive Cancer Center Support Grant (CCSG) | 2 | 2025 |
| P30CA014599 | Cancer Center Support Grant | 2 | 2025 |
1 to 10 of 854Source NIH's project files
See all 854 nih grantsPapers1,489
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Nicotinamide N-methyltransferase deficiency disrupts endometrial decidualization partly through dysregulated H3K27 trimethylation in recurrent implantation failure. | Mol Cell Endocrinol | 2027 | 42705148 | PubTator, text mining | PubMed |
| Statement of retraction: Effect of nicotinamide N-methyltransferase on lipid accumulation in 3T3-L1 adipocytes. | Bioengineered | 2026 | 42821468 | PubTator, text mining | PubMed |
| Targeting nicotinamide metabolism to reprogram the tumor microenvironment: Mechanisms and novel therapeutic strategies. | Crit Rev Oncol Hematol | 2026 | 42800593 | PubTator, text mining | PubMed |
| Nicotinamide N-methyltransferase in tumor stroma-immune crosstalk: Metabolic-epigenetic mechanisms and translational opportunities. | Int Immunopharmacol | 2026 | 42772041 | PubTator, text mining | PubMed |
| Characterizing the Transcriptional Features That Underlie Established Injury and Disease Progression in Diabetic Kidney Disease. | Kidney360 | 2026 | 42747892 | PubTator, text mining | PubMed |
| NNMT-associated metabolic-thromboinflammatory-immune co-activation in heterogeneous CTC clusters: a hypothesis-generating computational framework". | BMC Cancer | 2026 | 42723032 | PubTator, text mining | PubMed |
| Metabolic-epigenetic vulnerability in cardiometabolic HFpEF: One-carbon metabolism, DNMT maintenance, and methylation instability. | Pharmacol Res | 2026 | 42624311 | PubTator, text mining | PubMed |
| When muscles matter in SORD neuropathy. | J Neuropathol Exp Neurol | 2026 | 42616755 | PubTator, text mining | PubMed |
| Multi-omics analysis identifies a hepatocyte-associated signature in alcohol-related liver injury. | Front Immunol | 2026 | 42558149 | PubTator, text mining | PubMed |
| NNMT Loss Drives Cancer Progression by enhancing SAM availability for mTORC1 Signaling and Chromatin Methylation. | bioRxiv | 2026 | 42553046 | PubTator, text mining | PubMed |
1 to 10 of 1,489
See all 1,489 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4837
GET https://conductscience.org/api/genes/v1/4837/patents?page=2