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NOS1: nitric oxide synthase 1

1 protein, 33 patents, 2 drugs, 18 trials, 5,988 NIH grants and 11,687 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNOS1HGNC
Namenitric oxide synthase 1HGNC
NCBI Gene ID4842NCBI Gene
HGNC IDHGNC:7872HGNC
EnsemblENSG00000089250NCBI Gene
AliasesIHPS1, N-NOS, NC-NOS, NOS, bNOS, nNOSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P29475Nitric oxide synthase 11,434122Ensembl, GeneID, HGNCUniProt

Patents 33

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455784P29475Espacenet
EP 4641201 A22025-10-294923P29475Espacenet
JP 2025517969 A2025-06-124923P29475Espacenet
JP 2025032204 A2025-03-1132433P29475Espacenet
JP 2025502844 A2025-01-2810P29475Espacenet
EP 4460314 A22024-11-1310P29475Espacenet
EP 4461818 A22024-11-1332433P29475Espacenet
JP 2023519296 A2023-05-1042P29475Espacenet
JP 2023519296 A2023-05-1064P29475Espacenet
JP 2023058610 A2023-04-2532433P29475Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
TILARGININECHEMBL256147Nitric oxide synthase inhibitorINHIBITORChEMBL
TILARGININE ACETATECHEMBL1256175Nitric oxide synthase inhibitorINHIBITORChEMBL

Trials 18

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05660083TILARGININEPHASE2ClinicalTrials.gov
NCT03236935TILARGININEPHASE1ClinicalTrials.gov
NCT02966665TILARGININEPHASE1ClinicalTrials.gov
NCT02936687TILARGININEPHASE1ClinicalTrials.gov
NCT02834403TILARGININEPHASE1/PHASE22023-12-15ClinicalTrials.gov
NCT01617551TILARGININEClinicalTrials.gov
NCT01122407TILARGININEPHASE1ClinicalTrials.gov
NCT00580619TILARGININEPHASE1ClinicalTrials.gov
NCT00508989TILARGININEPHASE2ClinicalTrials.gov
NCT00344916TILARGININEPHASE1ClinicalTrials.gov

NIH grants 5988

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant332,025NIH's project files
P30CA016672Cancer Center Support Grant252,025NIH's project files
R01DK057061Calcium Dynamics in Interstitial Cells of Cajal132,025NIH's project files
P30DK084567Mayo Center for Cell Signaling in Gastroenterology122,025NIH's project files
R01AR040864Dystrophin Replacement122,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award122,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)92,025NIH's project files
P30CA086862Cancer Center Support Grant92,025NIH's project files
P30ES007048Environmental Exposures, Host Factors and Human Disease92,025NIH's project files
R01NS090634Whole body single AAV microgene in canine DMD92,025NIH's project files

Papers 11687

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42806308PubTator, text miningPubMed
42795384PubTator, text miningPubMed
42793291PubTator, text miningPubMed
42791659PubTator, text miningPubMed
42785170PubTator, text miningPubMed
42767439PubTator, text miningPubMed
42746669PubTator, text miningPubMed
42743758PubTator, text miningPubMed
42722222PubTator, text miningPubMed
42718587PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license