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NOS2: nitric oxide synthase 2

1 protein, 49 patents, 4 drugs, 23 trials, 15,833 NIH grants and 48,535 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNOS2HGNC
Namenitric oxide synthase 2HGNC
NCBI Gene ID4843NCBI Gene
HGNC IDHGNC:7873HGNC
EnsemblENSG00000007171NCBI Gene
AliasesHEP-NOS, INOS, NOS, NOS2A, iNOSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P35228Nitric oxide synthase, inducible1,15313Ensembl, GeneID, HGNCUniProt

Patents 49

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455794P35228Espacenet
EP 4640849 A22025-10-29823P35228Espacenet
EP 4641201 A22025-10-295365P35228Espacenet
JP 2025519096 A2025-06-24823P35228Espacenet
JP 2025517969 A2025-06-125365P35228Espacenet
JP 2023123507 A2023-09-0517P35228Espacenet
US 11446398 B22022-09-2057096P35228Espacenet
JP 2022524081 A2022-04-27160067P35228Espacenet
US 11078247 B22021-08-037587P35228Espacenet
US 11041209 B22021-06-221450P35228Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
GW-274150CHEMBL114551Nitric oxide synthase, inducible inhibitorINHIBITORChEMBL
KD7040CHEMBL1911882Nitric oxide synthase, inducible inhibitorINHIBITORChEMBL
TILARGININECHEMBL256147Nitric oxide synthase inhibitorINHIBITORChEMBL
TILARGININE ACETATECHEMBL1256175Nitric oxide synthase inhibitorINHIBITORChEMBL

Trials 23

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05660083TILARGININEPHASE2ClinicalTrials.gov
NCT03236935TILARGININEPHASE1ClinicalTrials.gov
NCT02966665TILARGININEPHASE1ClinicalTrials.gov
NCT02936687TILARGININEPHASE1ClinicalTrials.gov
NCT02834403TILARGININEPHASE1/PHASE22023-12-15ClinicalTrials.gov
NCT01617551TILARGININEClinicalTrials.gov
NCT01122407TILARGININEPHASE1ClinicalTrials.gov
NCT00580619TILARGININEPHASE1ClinicalTrials.gov
NCT00576108KD7040PHASE2ClinicalTrials.gov
NCT00508989TILARGININEPHASE2ClinicalTrials.gov

NIH grants 15833

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant902,025NIH's project files
P30CA008748Cancer Center Support Grant572,025NIH's project files
P30DK058404Molecular and Cellular Basis for Digestive Diseases492,025NIH's project files
P30ES005022Rutgers Center for Environmental Exposure and Disease (CEED)452,025NIH's project files
R01ES004738Activated Macrophages and Ozone Toxicity392,025NIH's project files
P01CA116087H. pylori-induced Inflammation and Gastric Cancer312,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award312,025NIH's project files
P30CA023074University of Arizona Cancer Center - Cancer Center Support Grant242,025NIH's project files
P30CA016058Cancer Center Support Grant222,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)212,025NIH's project files

Papers 48535

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42820595PubTator, text miningPubMed
42816978PubTator, text miningPubMed
42816487PubTator, text miningPubMed
42806308PubTator, text miningPubMed
42803887PubTator, text miningPubMed
42797428PubTator, text miningPubMed
42794803PubTator, text miningPubMed
42794788PubTator, text miningPubMed
42792197PubTator, text miningPubMed
42785170PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license