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NOS3: nitric oxide synthase 3

1 protein, 27 patents, 2 drugs, 18 trials, 11,346 NIH grants and 33,452 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNOS3HGNC
Namenitric oxide synthase 3HGNC
NCBI Gene ID4846NCBI Gene
HGNC IDHGNC:7876HGNC
EnsemblENSG00000164867NCBI Gene
AliasesEC-NOS, ECNOS, MYMY8, NOSIII, cNOS, eNOSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P29474Nitric oxide synthase 31,203105Ensembl, GeneID, HGNCUniProt

Patents 27

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455796P29474Espacenet
EP 4640849 A22025-10-29494P29474Espacenet
EP 4641201 A22025-10-293392P29474Espacenet
JP 2025519096 A2025-06-24494P29474Espacenet
JP 2025517969 A2025-06-123392P29474Espacenet
JP 2023123507 A2023-09-05301P29474Espacenet
US 11446398 B22022-09-2057098P29474Espacenet
US 11408034 B22022-08-09521P29474Espacenet
JP 2022524081 A2022-04-27160069P29474Espacenet
US 11078247 B22021-08-037588P29474Espacenet

Drugs 2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
TILARGININECHEMBL256147Nitric oxide synthase inhibitorINHIBITORChEMBL
TILARGININE ACETATECHEMBL1256175Nitric oxide synthase inhibitorINHIBITORChEMBL

Trials 18

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05660083TILARGININEPHASE2ClinicalTrials.gov
NCT03236935TILARGININEPHASE1ClinicalTrials.gov
NCT02966665TILARGININEPHASE1ClinicalTrials.gov
NCT02936687TILARGININEPHASE1ClinicalTrials.gov
NCT02834403TILARGININEPHASE1/PHASE22023-12-15ClinicalTrials.gov
NCT01617551TILARGININEClinicalTrials.gov
NCT01122407TILARGININEPHASE1ClinicalTrials.gov
NCT00580619TILARGININEPHASE1ClinicalTrials.gov
NCT00508989TILARGININEPHASE2ClinicalTrials.gov
NCT00344916TILARGININEPHASE1ClinicalTrials.gov

NIH grants 11346

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
R01HL060190Metabolic reprogramming of smooth muscle cells in pulmonary hypertension492,025NIH's project files
P30CA016672Cancer Center Support Grant282,025NIH's project files
R01HL098032Omics, mice and men: Development of precision transfusion medicine282,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)242,025NIH's project files
R01HL070562Actions of Estrogen on Uterine Artery Endothelium222,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award212,025NIH's project files
P30DK048520Colorado Nutrition Obesity Research Center202,025NIH's project files
P30CA008748Cancer Center Support Grant192,025NIH's project files
P30DK036836Diabetes Research Center182,025NIH's project files
P30DK017047Diabetes Research Center172,025NIH's project files

Papers 33452

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42820258PubTator, text miningPubMed
42806308PubTator, text miningPubMed
42801580PubTator, text miningPubMed
42797451PubTator, text miningPubMed
42797039PubTator, text miningPubMed
42794803PubTator, text miningPubMed
42794774PubTator, text miningPubMed
42794771PubTator, text miningPubMed
42793172PubTator, text miningPubMed
42793133PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license