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NOTCH2: notch receptor 2

1 protein, 120 patents, 1 drug, 3 trials, 4,569 NIH grants and 7,944 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNOTCH2HGNC
Namenotch receptor 2HGNC
NCBI Gene ID4853NCBI Gene
HGNC IDHGNC:7882HGNC
EnsemblENSG00000134250NCBI Gene
AliasesAGS2, HJCYS, hN2NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q04721Neurogenic locus notch homolog protein 22,4712Ensembl, GeneID, HGNCUniProt

Patents 120

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026217567 A12026-10-1520Q04721Espacenet
JP 2026090543 A2026-06-02712Q04721Espacenet
JP 2026035773 A2026-03-0425Q04721Espacenet
JP 2026004568 A2026-01-1455927Q04721Espacenet
EP 4650780 A22025-11-191595Q04721Espacenet
EP 4641201 A22025-10-291204Q04721Espacenet
JP 2025534663 A2025-10-175Q04721Espacenet
JP 2025529142 A2025-09-042863Q04721Espacenet
EP 4601696 A12025-08-205Q04721Espacenet
US 12371689 B22025-07-292863Q04721Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
TAREXTUMABCHEMBL3301588Neurogenic locus notch homolog protein 2 inhibitorINHIBITORChEMBL

Trials 3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01859741TAREXTUMABPHASE1/PHASE22019-05-01ClinicalTrials.gov
NCT01647828TAREXTUMABPHASE1/PHASE22023-02-15ClinicalTrials.gov
NCT01277146TAREXTUMABPHASE1ClinicalTrials.gov

NIH grants 4569

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant742,025NIH's project files
P30CA016672Cancer Center Support Grant642,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award202,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028192,025NIH's project files
R01AI091627Notch Signaling in Alloimmunity172,025NIH's project files
P30DK026743UCSF Liver Center142,025NIH's project files
P30DK078392Digestive Health Center (DHC): Bench to Bedside Research in Pediatric Digestive Disease132,025NIH's project files
R01DK076077Adaptive and maladaptive repair after kidney injury132,025NIH's project files
P30CA006973Regional Oncology Research Center122,025NIH's project files
U01DK062481Advancing our Understanding of Rare Pediatric Liver Diseases112,025NIH's project files

Papers 7944

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42802826PubTator, text miningPubMed
42801944PubTator, text miningPubMed
42794834PubTator, text miningPubMed
42779706PubTator, text miningPubMed
42777203PubTator, text miningPubMed
42759523PubTator, text miningPubMed
42744251PubTator, text miningPubMed
42730850PubTator, text miningPubMed
42716992PubTator, text miningPubMed
42715516PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license