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NOTCH3: notch receptor 3

1 protein, 86 patents, 1 drug, 3 trials, 3,820 NIH grants and 7,740 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNOTCH3HGNC
Namenotch receptor 3HGNC
NCBI Gene ID4854NCBI Gene
HGNC IDHGNC:7883HGNC
EnsemblENSG00000074181NCBI Gene
AliasesCADASIL, CADASIL1, CARASIL1, CASIL, FPLD1, IMF2, LMNSNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q9UM47Neurogenic locus notch homolog protein 32,3216Ensembl, GeneID, HGNCUniProt

Patents 86

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12570741 B22026-03-1010Q9UM47Espacenet
JP 2026035773 A2026-03-0427Q9UM47Espacenet
JP 2026004568 A2026-01-1455932Q9UM47Espacenet
EP 4650780 A22025-11-192205Q9UM47Espacenet
WO 2025228986 A12025-11-0621Q9UM47Espacenet
EP 4644537 A12025-11-0521Q9UM47Espacenet
EP 4641201 A22025-10-291774Q9UM47Espacenet
JP 2025147176 A2025-10-069432Q9UM47Espacenet
JP 2025529142 A2025-09-042864Q9UM47Espacenet
JP 2025529142 A2025-09-047157Q9UM47Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
TAREXTUMABCHEMBL3301588Neurogenic locus notch homolog protein 3 inhibitorINHIBITORChEMBL

Trials 3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT01859741TAREXTUMABPHASE1/PHASE22019-05-01ClinicalTrials.gov
NCT01647828TAREXTUMABPHASE1/PHASE22023-02-15ClinicalTrials.gov
NCT01277146TAREXTUMABPHASE1ClinicalTrials.gov

NIH grants 3820

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant652,025NIH's project files
P30CA008748Cancer Center Support Grant542,025NIH's project files
I01BX003824Advanced conformational changes in NOTCH3 and cerebrovascular disease severity142,025NIH's project files
P30CA016058Cancer Center Support Grant122,025NIH's project files
P30CA068485Cancer Center Support Grant122,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award122,025NIH's project files
P30CA016520Abramson Cancer Center Support Grant102,025NIH's project files
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-2028102,025NIH's project files
P30DK050306Center for Molecular Studies in Digestive and Liver Diseases102,025NIH's project files
P30CA006973Regional Oncology Research Center92,025NIH's project files

Papers 7740

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818124PubTator, text miningPubMed
42818080PubTator, text miningPubMed
42811994PubTator, text miningPubMed
42809705PubTator, text miningPubMed
42805883PubTator, text miningPubMed
42800975PubTator, text miningPubMed
42799816PubTator, text miningPubMed
42726640PubTator, text miningPubMed
42712799PubTator, text miningPubMed
42711069PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license