Gene · 4855
NOTCH4: notch receptor 4
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NOTCH4: notch receptor 4. Genes, record 4855. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4855
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q99466 | Neurogenic locus notch homolog protein 4 | 2,003 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents108
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026035773 A | 2026-03-04 | 28 | Q99466 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 55934 | Q99466 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 55940 | Q99466 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 9562 | Q99466 | Espacenet |
| WO 2025228986 A1 | 2025-11-06 | 22 | Q99466 | Espacenet |
| EP 4644537 A1 | 2025-11-05 | 22 | Q99466 | Espacenet |
| EP 4640849 A2 | 2025-10-29 | 1441 | Q99466 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 9820 | Q99466 | Espacenet |
| JP 2025533355 A | 2025-10-06 | 137 | Q99466 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2865 | Q99466 | Espacenet |
1 to 10 of 108
See all 108 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,743
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NOTCH4 papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 22 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 19 | 2025 |
| R01AI065617 | Genetic and Epigenetic Programming of Allergic Airway Inflammation | 11 | 2025 |
| P30CA076292 | Moffitt Cancer Center Support Grant | 8 | 2025 |
| R01HL117913 | The NOTCH Signaling Pathway in Large Vessel Vasculitis | 8 | 2025 |
| P30CA046592 | University of Michigan Rogel Cancer Center Support Grant 2023-2028 | 7 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 7 | 2025 |
| P30CA006973 | Regional Oncology Research Center | 6 | 2025 |
| P30CA016058 | Cancer Center Support Grant | 6 | 2025 |
| P30CA047904 | Cancer Center Support Grant | 6 | 2025 |
1 to 10 of 2,743Source NIH's project files
See all 2,743 nih grantsPapers3,624
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| AVP-GPT2: Prompt-conditioned fine-tuning of a GPT-2 protein language model for antiviral peptide identification. | Eur J Med Chem | 2026 | 42800116 | PubTator, text mining | PubMed |
| Genetic factors associated with COVID-19 severity and mortality: TYK2 and NOTCH4. | Biomed Rep | 2026 | 42769501 | PubTator, text mining | PubMed |
| Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte-to-DC Differentiation Via Microbiota-Associated IAA. | Adv Sci (Weinh) | 2026 | 42750356 | PubTator, text mining | PubMed |
| Genetic context shapes interpretation of AIRE and Notch4 in alopecia areata. | JID Innov | 2026 | 42633099 | PubTator, text mining | PubMed |
| MLL1 Regulates T-Cell Phenotype via Notch Signaling During Abdominal Aortic Aneurysm Development. | Arterioscler Thromb Vasc Biol | 2026 | 42619610 | PubTator, text mining | PubMed |
| Reimagining VEGF Therapy: The Role of PLCγ2 in Pan-Organ Endothelial Networks. | Adv Wound Care (New Rochelle) | 2026 | 42552235 | PubTator, text mining | PubMed |
| Notch3/4 Knockdown Inhibits Colon Adenocarcinoma Progression by Suppressing Tumor Cell Activity and Orchestrating VEGFA-Dependent Tumor Immune Microenvironment. | Cancer Med | 2026 | 42458230 | PubTator, text mining | PubMed |
| Characterizing tumor-associated endothelial cells in clear cell renal cell carcinoma via scRNA-seq and Bulk RNA-seq: construction of a prognostic risk signature. | Arch Biochem Biophys | 2026 | 42392347 | PubTator, text mining | PubMed |
| Response to correspondence on 'Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis' by Kaundal et al. | Ann Rheum Dis | 2026 | 42379678 | PubTator, text mining | PubMed |
| Correspondence on 'Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis' by Kaundal et al. | Ann Rheum Dis | 2026 | 42379677 | PubTator, text mining | PubMed |
1 to 10 of 3,624
See all 3,624 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4855
GET https://conductscience.org/api/genes/v1/4855/patents?page=2