ConductScience.org, home

Gene · 4855

NOTCH4: notch receptor 4

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. NOTCH4: notch receptor 4. Genes, record 4855. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4855

On this page

Gene

Symbol
NOTCH4
HGNC
Name
notch receptor 4
HGNC
NCBI Gene ID
4855
NCBI Gene
HGNC ID
HGNC:7884
HGNC
Ensembl
ENSG00000204301
NCBI Gene
Aliases
INT3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99466Neurogenic locus notch homolog protein 42,0033Ensembl, GeneID, HGNC

Source UniProt

Patents108

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026035773 A2026-03-0428Q99466Espacenet
JP 2026004568 A2026-01-1455934Q99466Espacenet
JP 2026004568 A2026-01-1455940Q99466Espacenet
EP 4650780 A22025-11-199562Q99466Espacenet
WO 2025228986 A12025-11-0622Q99466Espacenet
EP 4644537 A12025-11-0522Q99466Espacenet
EP 4640849 A22025-10-291441Q99466Espacenet
EP 4641201 A22025-10-299820Q99466Espacenet
JP 2025533355 A2025-10-06137Q99466Espacenet
JP 2025529142 A2025-09-042865Q99466Espacenet

1 to 10 of 108

See all 108 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,743

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNOTCH4 papersNewest fiscal year
P30CA016672Cancer Center Support Grant222025
P30CA008748Cancer Center Support Grant192025
R01AI065617Genetic and Epigenetic Programming of Allergic Airway Inflammation112025
P30CA076292Moffitt Cancer Center Support Grant82025
R01HL117913The NOTCH Signaling Pathway in Large Vessel Vasculitis82025
P30CA046592University of Michigan Rogel Cancer Center Support Grant 2023-202872025
UL1TR001863Yale Clinical and Translational Science Award72025
P30CA006973Regional Oncology Research Center62025
P30CA016058Cancer Center Support Grant62025
P30CA047904Cancer Center Support Grant62025

1 to 10 of 2,743Source NIH's project files

See all 2,743 nih grants

Papers3,624

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
AVP-GPT2: Prompt-conditioned fine-tuning of a GPT-2 protein language model for antiviral peptide identification.Eur J Med Chem202642800116PubTator, text miningPubMed
Genetic factors associated with COVID-19 severity and mortality: TYK2 and NOTCH4.Biomed Rep202642769501PubTator, text miningPubMed
Lactiplantibacillus Plantarum GUANKE Alleviates Allergic Asthma by Restricting Monocyte-to-DC Differentiation Via Microbiota-Associated IAA.Adv Sci (Weinh)202642750356PubTator, text miningPubMed
Genetic context shapes interpretation of AIRE and Notch4 in alopecia areata.JID Innov202642633099PubTator, text miningPubMed
MLL1 Regulates T-Cell Phenotype via Notch Signaling During Abdominal Aortic Aneurysm Development.Arterioscler Thromb Vasc Biol202642619610PubTator, text miningPubMed
Reimagining VEGF Therapy: The Role of PLCγ2 in Pan-Organ Endothelial Networks.Adv Wound Care (New Rochelle)202642552235PubTator, text miningPubMed
Notch3/4 Knockdown Inhibits Colon Adenocarcinoma Progression by Suppressing Tumor Cell Activity and Orchestrating VEGFA-Dependent Tumor Immune Microenvironment.Cancer Med202642458230PubTator, text miningPubMed
Characterizing tumor-associated endothelial cells in clear cell renal cell carcinoma via scRNA-seq and Bulk RNA-seq: construction of a prognostic risk signature.Arch Biochem Biophys202642392347PubTator, text miningPubMed
Response to correspondence on 'Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis' by Kaundal et al.Ann Rheum Dis202642379678PubTator, text miningPubMed
Correspondence on 'Gain of function NOTCH4 variants disrupt angiogenesis in systemic sclerosis' by Kaundal et al.Ann Rheum Dis202642379677PubTator, text miningPubMed

1 to 10 of 3,624

See all 3,624 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4855

GET https://conductscience.org/api/genes/v1/4855/patents?page=2