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Gene · 486

FXYD2: FXYD domain containing ion transport regulator 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. FXYD2: FXYD domain containing ion transport regulator 2. Genes, record 486. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/486

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Gene

Symbol
FXYD2
HGNC
Name
FXYD domain containing ion transport regulator 2
HGNC
NCBI Gene ID
486
NCBI Gene
HGNC ID
HGNC:4026
HGNC
Ensembl
ENSG00000137731
NCBI Gene
Aliases
ATP1G1, HOMG2, MGC12372
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P54710Sodium/potassium-transporting ATPase subunit gamma664Ensembl, GeneID, HGNC

Source UniProt

Patents24

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1446793P54710Espacenet
EP 4641202 A22025-10-29180P54710Espacenet
JP 2025529142 A2025-09-041631P54710Espacenet
US 12371689 B22025-07-291631P54710Espacenet
KR 1020250017231 A2025-02-04180P54710Espacenet
US 11446398 B22022-09-2033116P54710Espacenet
JP 2022524081 A2022-04-27136087P54710Espacenet
US 11078247 B22021-08-034243P54710Espacenet
JP 2019065025 A2019-04-2513P54710Espacenet
JP 2019054813 A2019-04-11227228P54710Espacenet

1 to 10 of 24

See all 24 patents

Drugs6

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ACETYLDIGITOXINCHEMBL3545057Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
DESLANOSIDECHEMBL1614Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
DIGITOXINCHEMBL254219Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
DIGOXINCHEMBL1751Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
ISTAROXIMECHEMBL2093999Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL
LANATOSIDE CCHEMBL506569Sodium/potassium-transporting ATPase inhibitorINHIBITORChEMBL

Trials55

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

NIH grants372

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleFXYD2 papersNewest fiscal year
P30CA030199Cancer Center Support Grant (CCSG)42025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center22025
P30CA068485Cancer Center Support Grant22025
P30CA091842Cancer Center Support Grant22025
P30DK036836Diabetes Research Center22025
R01DK114233Studying the Role of the Microenvironment on Differentiation and Maturation of Beta Cells22025
UL1TR001863Yale Clinical and Translational Science Award22025
DP1DA054343Epigenomic labeling of cells that drive drug abuse behavior12025
K01DK134848Genetic and pharmacologic inhibition of ALDH1A3 as a treatment of beta cell failure12025
P30AR070155RESOURCE-BASED CENTER FOR THE ADVANCEMENT OF PRECISION MEDICINE IN RHEUMATOLOGY12025

1 to 10 of 372Source NIH's project files

See all 372 nih grants

Papers454

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Genetic Variants of Na+,K+-ATPase Associated With Neurological Disorders: A Systematic Review.Am J Med Genet B Neuropsychiatr Genet202642764777PubTator, text miningPubMed
Urinary proteomic signature of exercise intolerance in patients at risk of heart failure: evidence from the HOMAGE trial.EBioMedicine202642531722PubTator, text miningPubMed
Magnesium sulfate attenuates sepsis-induced myocardial injury through macrophage Fxyd2/NF-κB signaling: Integrated evidence from a propensity-matched cohort, single-cell atlas, and mechanistic validation.
Toxicol Appl Pharmacol202642303054PubTator, text miningPubMed
Lactate metabolism orchestrates immune dysregulation in renal cancer: A multi-omics and causal inference study.Sci Prog202541406083PubTator, text miningPubMed
Identifying survival subtypes with autoencoder using multiple types of high-dimensional genomic data from studies of glioblastoma multiforme.Brief Bioinform202541016009PubTator, text miningPubMed
Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning.Elife202540982369PubTator, text miningPubMed
Leukemia inhibitory factor promotes human cholangiopathies, and its inhibition improves cholestasis in Abcb4-/- mice.Hepatol Commun202540857400PubTator, text miningPubMed
Single-cell transcriptome analysis of in vivo and in vitro human pancreas development.Genes Dis202540735693PubTator, text miningPubMed
The prognostic and immune significance of fibronectin type III domain-containing 1 gene in pan-cancer and its relationship with proliferation and migration of stomach adenocarcinoma.Transl Cancer Res202540530118PubTator, text miningPubMed
FXYD2 marks and regulates maturity of β cells via ion channel-mediated signal transduction.Nat Commun202540467586PubTator, text miningPubMed

1 to 10 of 454

See all 454 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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