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Gene · 4862

NPAS2: neuronal PAS domain protein 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NPAS2: neuronal PAS domain protein 2. Genes, record 4862. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4862

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Gene

Symbol
NPAS2
HGNC
Name
neuronal PAS domain protein 2
HGNC
NCBI Gene ID
4862
NCBI Gene
HGNC ID
HGNC:7895
HGNC
Ensembl
ENSG00000170485
NCBI Gene
Aliases
MOP4, PASD4, bHLHe9
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99743Neuronal PAS domain-containing protein 28240Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455523Q99743Espacenet
EP 4641201 A22025-10-296102Q99743Espacenet
JP 2025147176 A2025-10-0615410Q99743Espacenet
JP 2025517969 A2025-06-126102Q99743Espacenet
JP 2025028160 A2025-02-2815410Q99743Espacenet
KR 1020250010750 A2025-01-2115410Q99743Espacenet
JP 2024109657 A2024-08-1415249Q99743Espacenet
US 11446398 B22022-09-2056530Q99743Espacenet
JP 2022092366 A2022-06-22745Q99743Espacenet
JP 2022524081 A2022-04-27159501Q99743Espacenet

1 to 10 of 19

See all 19 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,279

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNPAS2 papersNewest fiscal year
P30DK056338Texas Medical Center Digestive Diseases Center62025
P30EY006360P30-Core Grant for Vision Research42025
P50DA039841Center for Systems Neurogenetics of Addiction42025
P30CA016672Cancer Center Support Grant32025
P30DK072476Pennington/Louisiana NORC32025
R01DK090625Integration of Feeding Time and Glucose Metabolism by the Circadian Gene Network32025
T32DK007169NW University Program in Endo Diabetes and Hormone Action32025
U54GM104942West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health32025
ZIAES101586Nuclear receptors: action, functions, and roles in disease32025
P30AG028740University of Florida Older Americans Independence Center (OAIC)22025

1 to 10 of 1,279Source NIH's project files

See all 1,279 nih grants

Papers1,384

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Clock-Related Genes Mark a Developmental Cortical Maturation Program Associated with Stage-Resolved Responses to Prenatal Immune Activation.Genes (Basel)202642793001PubTator, text miningPubMed
The circadian clock component NPAS2 is modulated by AMPK and regulates substrate utilization and mitochondrial function in human skeletal muscle cells.Mol Metab202642762975PubTator, text miningPubMed
Sustained hypoxia induces divergent response patterns in cardiac metabolic-immune adaptation and circadian rhythm regulation.PLoS One202642726733PubTator, text miningPubMed
A model of cellular proliferation and mitochondrial biogenesis predicts prognosis and immunotherapy response in lung adenocarcinoma.Transl Cancer Res202642724831PubTator, text miningPubMed
Seasonal metabolic oscillation: adiposity cycling as a candidate amplifier of mood seasonality in seasonal affective and bipolar disorders.Front Psychiatry202642609474PubTator, text miningPubMed
Next-generation DNA methylation sequencing: loci and regions differentially methylated in adolescents with chronic postsurgical pain.Neurobiol Pain202642602478PubTator, text miningPubMed
Deciphering the circadian signature in acute myeloid leukemia: NPAS2 downregulation as a master predictive feature.Blood Res202642584798PubTator, text miningPubMed
Ambient PM2.5 exposure and sleep quality: Evidence from circadian DNA methylation signatures in a population-based study.J Hazard Mater202642537304PubTator, text miningPubMed
The elevated clock genes involved in regulating the hormone secretion and follicular development during the laying period of geese.Anim Reprod Sci202642287886PubTator, text miningPubMed
Temporal single-cell atlas of full-length Huntington's disease mouse model defines stage-specific signatures of corticostriatal dysfunction.Mol Neurodegener202642210302PubTator, text miningPubMed

1 to 10 of 1,384

See all 1,384 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4862

GET https://conductscience.org/api/genes/v1/4862/patents