Gene · 4862
NPAS2: neuronal PAS domain protein 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NPAS2: neuronal PAS domain protein 2. Genes, record 4862. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4862
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q99743 | Neuronal PAS domain-containing protein 2 | 824 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents19
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 55523 | Q99743 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6102 | Q99743 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15410 | Q99743 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6102 | Q99743 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15410 | Q99743 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15410 | Q99743 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15249 | Q99743 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 56530 | Q99743 | Espacenet |
| JP 2022092366 A | 2022-06-22 | 745 | Q99743 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 159501 | Q99743 | Espacenet |
1 to 10 of 19
See all 19 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,279
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NPAS2 papers | Newest fiscal year |
|---|---|---|---|
| P30DK056338 | Texas Medical Center Digestive Diseases Center | 6 | 2025 |
| P30EY006360 | P30-Core Grant for Vision Research | 4 | 2025 |
| P50DA039841 | Center for Systems Neurogenetics of Addiction | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30DK072476 | Pennington/Louisiana NORC | 3 | 2025 |
| R01DK090625 | Integration of Feeding Time and Glucose Metabolism by the Circadian Gene Network | 3 | 2025 |
| T32DK007169 | NW University Program in Endo Diabetes and Hormone Action | 3 | 2025 |
| U54GM104942 | West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health | 3 | 2025 |
| ZIAES101586 | Nuclear receptors: action, functions, and roles in disease | 3 | 2025 |
| P30AG028740 | University of Florida Older Americans Independence Center (OAIC) | 2 | 2025 |
1 to 10 of 1,279Source NIH's project files
See all 1,279 nih grantsPapers1,384
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Clock-Related Genes Mark a Developmental Cortical Maturation Program Associated with Stage-Resolved Responses to Prenatal Immune Activation. | Genes (Basel) | 2026 | 42793001 | PubTator, text mining | PubMed |
| The circadian clock component NPAS2 is modulated by AMPK and regulates substrate utilization and mitochondrial function in human skeletal muscle cells. | Mol Metab | 2026 | 42762975 | PubTator, text mining | PubMed |
| Sustained hypoxia induces divergent response patterns in cardiac metabolic-immune adaptation and circadian rhythm regulation. | PLoS One | 2026 | 42726733 | PubTator, text mining | PubMed |
| A model of cellular proliferation and mitochondrial biogenesis predicts prognosis and immunotherapy response in lung adenocarcinoma. | Transl Cancer Res | 2026 | 42724831 | PubTator, text mining | PubMed |
| Seasonal metabolic oscillation: adiposity cycling as a candidate amplifier of mood seasonality in seasonal affective and bipolar disorders. | Front Psychiatry | 2026 | 42609474 | PubTator, text mining | PubMed |
| Next-generation DNA methylation sequencing: loci and regions differentially methylated in adolescents with chronic postsurgical pain. | Neurobiol Pain | 2026 | 42602478 | PubTator, text mining | PubMed |
| Deciphering the circadian signature in acute myeloid leukemia: NPAS2 downregulation as a master predictive feature. | Blood Res | 2026 | 42584798 | PubTator, text mining | PubMed |
| Ambient PM2.5 exposure and sleep quality: Evidence from circadian DNA methylation signatures in a population-based study. | J Hazard Mater | 2026 | 42537304 | PubTator, text mining | PubMed |
| The elevated clock genes involved in regulating the hormone secretion and follicular development during the laying period of geese. | Anim Reprod Sci | 2026 | 42287886 | PubTator, text mining | PubMed |
| Temporal single-cell atlas of full-length Huntington's disease mouse model defines stage-specific signatures of corticostriatal dysfunction. | Mol Neurodegener | 2026 | 42210302 | PubTator, text mining | PubMed |
1 to 10 of 1,384
See all 1,384 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4862
GET https://conductscience.org/api/genes/v1/4862/patents