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NPC1: NPC intracellular cholesterol transporter 1

1 protein, 43 patents, 0 drugs, 0 trials, 3,401 NIH grants and 5,170 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNPC1HGNC
NameNPC intracellular cholesterol transporter 1HGNC
NCBI Gene ID4864NCBI Gene
HGNC IDHGNC:7897HGNC
EnsemblENSG00000141458NCBI Gene
AliasesNPC, POGZ, SLC65A1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O15118NPC intracellular cholesterol transporter 11,27820Ensembl, GeneID, HGNCUniProt

Patents 43

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21294O15118Espacenet
JP 2026004568 A2026-01-1455710O15118Espacenet
EP 4650780 A22025-11-192699O15118Espacenet
EP 4640849 A22025-10-29331O15118Espacenet
EP 4641201 A22025-10-292285O15118Espacenet
JP 2025529142 A2025-09-042872O15118Espacenet
US 12371689 B22025-07-292872O15118Espacenet
JP 2025519096 A2025-06-24331O15118Espacenet
JP 2025517969 A2025-06-122285O15118Espacenet
JP 2025517970 A2025-06-122699O15118Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 3401

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
ZIATR000018Drug Repurposing Screening for Rare and Neglected Diseases212,025NIH's project files
P30DK020579Diabetes Research Center152,025NIH's project files
P30CA014195Cancer Center Support Grant (CCSG)132,025NIH's project files
P30CA008748Cancer Center Support Grant112,025NIH's project files
P30DK056341Washington University Nutrition Obesity Research Center112,025NIH's project files
R01DK038389Lipid transport in the intestine92,025NIH's project files
R35GM118082Signal transduction in development and disease72,025NIH's project files
ZIAAI001089Viral Hemorrhagic Fevers: Disease Modeling and Transmission72,025NIH's project files
ZIAHD008988Basic and Translational Studies of Inborn Errors of Metabolism72,025NIH's project files
P30CA016059Massey Cancer Center - Cancer Center Support Grant62,025NIH's project files

Papers 5170

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42761304PubTator, text miningPubMed
42751242PubTator, text miningPubMed
42701886PubTator, text miningPubMed
42694163PubTator, text miningPubMed
42691865PubTator, text miningPubMed
42665096PubTator, text miningPubMed
42620007PubTator, text miningPubMed
42613861PubTator, text miningPubMed
42606057PubTator, text miningPubMed
42598967PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license