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Gene · 488

ATP2A2: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ATP2A2: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2. Genes, record 488. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/488

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Gene

Symbol
ATP2A2
HGNC
Name
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
HGNC
NCBI Gene ID
488
NCBI Gene
HGNC ID
HGNC:812
HGNC
Ensembl
ENSG00000174437
NCBI Gene
Aliases
ATP2B, DAR, DD, RHABDO2, SERCA2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P16615Sarcoplasmic/endoplasmic reticulum calcium ATPase 21,04215Ensembl, GeneID, HGNC

Source UniProt

Patents56

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026027383 A2026-02-1829P16615Espacenet
JP 2026004568 A2026-01-1438169P16615Espacenet
EP 4650780 A22025-11-1916081P16615Espacenet
EP 4641201 A22025-10-2919535P16615Espacenet
JP 2025529142 A2025-09-04506P16615Espacenet
US 12371689 B22025-07-29506P16615Espacenet
JP 2025517969 A2025-06-1219535P16615Espacenet
JP 2025517970 A2025-06-1216081P16615Espacenet
US 12305189 B22025-05-201804P16615Espacenet
JP 2025062604 A2025-04-147242P16615Espacenet

1 to 10 of 56

See all 56 patents

Drugs2

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ISTAROXIMECHEMBL2093999Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 activatorACTIVATORChEMBL
MIPSAGARGINCHEMBL3989865Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitorINHIBITORChEMBL

Trials12

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT05975021ISTAROXIMEPHASE1/PHASE2ClinicalTrials.gov
NCT02876003MIPSAGARGINPHASE2ClinicalTrials.gov
NCT02617446ISTAROXIMEPHASE22023-05-24ClinicalTrials.gov
NCT02607553MIPSAGARGINPHASE2ClinicalTrials.gov
NCT02381236MIPSAGARGINPHASE2ClinicalTrials.gov
NCT02082691MIPSAGARGINClinicalTrials.gov
NCT02067156MIPSAGARGINPHASE22024-05-21ClinicalTrials.gov
NCT01777594MIPSAGARGINPHASE2ClinicalTrials.gov
NCT01734681MIPSAGARGINPHASE2ClinicalTrials.gov
NCT00869115ISTAROXIMEPHASE1ClinicalTrials.gov

1 to 10 of 12

See all 12 trials

NIH grants2,537

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleATP2A2 papersNewest fiscal year
R01AR041836Function of Desmoglein 1/Pemphigus Foliaceus Antigen62025
R01HL130020Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs62025
P30CA060553The Robert H. Lurie Comprehensive Cancer Center52025
P30DK097512Indiana Diabetes Research Center52025
R01AR043380Desmoplakin Assembly and Function in Epidermis52025
R01HL092321Regulation of Cardiac Calcium Transport52025
R01HL139065Protein structural biophysics driving drug discovery for cardiac calcium transport regulation, producing translational advances and mechanistic insights52025
I01BX001733Regulation of calcium homeostasis in the pancreatic beta cell42025
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology42025
P30CA016672Cancer Center Support Grant42025

1 to 10 of 2,537Source NIH's project files

See all 2,537 nih grants

Papers3,333

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
The anion channel GPR89 is a tumor-specific dependency in breast cancer.Nat Commun202642773111PubTator, text miningPubMed
β-carotene alleviates PM2.5-induced pulmonary fibrosis via suppression of the Frizzled5-mediated Wnt5a/Ca2+pathway.Ecotoxicol Environ Saf202642759460PubTator, text miningPubMed
Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.J Precis Med (Amst)202642644057PubTator, text miningPubMed
Age-Opposed Rewiring of Upstream Translation-Initiation Pattern Across Different Types of Human Cancers.OMICS202642610666PubTator, text miningPubMed
Secukinumab in Refractory Generalized Darier's Disease with a 40-Year Disease Duration: A Case Report.Clin Cosmet Investig Dermatol202642610100PubTator, text miningPubMed
Failed metabolic adaptation to stress contributes to epidermal cell adhesion defects in Darier disease.Sci Adv202642555718PubTator, text miningPubMed
Markedly improved disease control in Darier disease (ATP2A2-nonsyndromic epidermal differentiation disorder) with ustekinumab versus other biologics: a case series.Skin Health Dis202642539885PubTator, text miningPubMed
SERCA2 gatekeeper role in aortic autophagy: targeting the Ca2+-mTOR axis to prevent aortic dissection.Acta Pharmacol Sin202642509384PubTator, text miningPubMed
A case of ATP2A2-nonsyndromic epidermal differentiation disorder with a novel ATP2A2 variant and schizophrenia.Eur J Dermatol202642507412PubTator, text miningPubMed
When calcium crosstalk turns ferroptotic: the SERCA2-VDAC1 axis in AKI.Kidney Int202642476679PubTator, text miningPubMed

1 to 10 of 3,333

See all 3,333 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

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The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/488

GET https://conductscience.org/api/genes/v1/488/patents?page=2