Gene · 488
ATP2A2: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ATP2A2: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2. Genes, record 488. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/488
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P16615 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 | 1,042 | 15 | Ensembl, GeneID, HGNC |
Source UniProt
Patents56
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026027383 A | 2026-02-18 | 29 | P16615 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 38169 | P16615 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 16081 | P16615 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 19535 | P16615 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 506 | P16615 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 506 | P16615 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 19535 | P16615 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 16081 | P16615 | Espacenet |
| US 12305189 B2 | 2025-05-20 | 1804 | P16615 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 7242 | P16615 | Espacenet |
1 to 10 of 56
See all 56 patentsDrugs2
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials12
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT05975021 | ISTAROXIME | PHASE1/PHASE2 | ClinicalTrials.gov | |
| NCT02876003 | MIPSAGARGIN | PHASE2 | ClinicalTrials.gov | |
| NCT02617446 | ISTAROXIME | PHASE2 | 2023-05-24 | ClinicalTrials.gov |
| NCT02607553 | MIPSAGARGIN | PHASE2 | ClinicalTrials.gov | |
| NCT02381236 | MIPSAGARGIN | PHASE2 | ClinicalTrials.gov | |
| NCT02082691 | MIPSAGARGIN | ClinicalTrials.gov | ||
| NCT02067156 | MIPSAGARGIN | PHASE2 | 2024-05-21 | ClinicalTrials.gov |
| NCT01777594 | MIPSAGARGIN | PHASE2 | ClinicalTrials.gov | |
| NCT01734681 | MIPSAGARGIN | PHASE2 | ClinicalTrials.gov | |
| NCT00869115 | ISTAROXIME | PHASE1 | ClinicalTrials.gov |
1 to 10 of 12
See all 12 trialsNIH grants2,537
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ATP2A2 papers | Newest fiscal year |
|---|---|---|---|
| R01AR041836 | Function of Desmoglein 1/Pemphigus Foliaceus Antigen | 6 | 2025 |
| R01HL130020 | Elucidating Mechanism of Cardiac Fibrosis with Cell Village of Pooled Human iPSCs | 6 | 2025 |
| P30CA060553 | The Robert H. Lurie Comprehensive Cancer Center | 5 | 2025 |
| P30DK097512 | Indiana Diabetes Research Center | 5 | 2025 |
| R01AR043380 | Desmoplakin Assembly and Function in Epidermis | 5 | 2025 |
| R01HL092321 | Regulation of Cardiac Calcium Transport | 5 | 2025 |
| R01HL139065 | Protein structural biophysics driving drug discovery for cardiac calcium transport regulation, producing translational advances and mechanistic insights | 5 | 2025 |
| I01BX001733 | Regulation of calcium homeostasis in the pancreatic beta cell | 4 | 2025 |
| P01HL141084 | Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
1 to 10 of 2,537Source NIH's project files
See all 2,537 nih grantsPapers3,333
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| The anion channel GPR89 is a tumor-specific dependency in breast cancer. | Nat Commun | 2026 | 42773111 | PubTator, text mining | PubMed |
| β-carotene alleviates PM2.5-induced pulmonary fibrosis via suppression of the Frizzled5-mediated Wnt5a/Ca2+pathway. | Ecotoxicol Environ Saf | 2026 | 42759460 | PubTator, text mining | PubMed |
| Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart. | J Precis Med (Amst) | 2026 | 42644057 | PubTator, text mining | PubMed |
| Age-Opposed Rewiring of Upstream Translation-Initiation Pattern Across Different Types of Human Cancers. | OMICS | 2026 | 42610666 | PubTator, text mining | PubMed |
| Secukinumab in Refractory Generalized Darier's Disease with a 40-Year Disease Duration: A Case Report. | Clin Cosmet Investig Dermatol | 2026 | 42610100 | PubTator, text mining | PubMed |
| Failed metabolic adaptation to stress contributes to epidermal cell adhesion defects in Darier disease. | Sci Adv | 2026 | 42555718 | PubTator, text mining | PubMed |
| Markedly improved disease control in Darier disease (ATP2A2-nonsyndromic epidermal differentiation disorder) with ustekinumab versus other biologics: a case series. | Skin Health Dis | 2026 | 42539885 | PubTator, text mining | PubMed |
| SERCA2 gatekeeper role in aortic autophagy: targeting the Ca2+-mTOR axis to prevent aortic dissection. | Acta Pharmacol Sin | 2026 | 42509384 | PubTator, text mining | PubMed |
| A case of ATP2A2-nonsyndromic epidermal differentiation disorder with a novel ATP2A2 variant and schizophrenia. | Eur J Dermatol | 2026 | 42507412 | PubTator, text mining | PubMed |
| When calcium crosstalk turns ferroptotic: the SERCA2-VDAC1 axis in AKI. | Kidney Int | 2026 | 42476679 | PubTator, text mining | PubMed |
1 to 10 of 3,333
See all 3,333 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/488
GET https://conductscience.org/api/genes/v1/488/patents?page=2