ConductScience.org, home

Gene · 4883

NPR3: natriuretic peptide receptor 3

12 sourcesgene-search-2026-11-11-0.2.0

Download JSON
Cite this record

ConductScience Library. NPR3: natriuretic peptide receptor 3. Genes, record 4883. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4883

On this page

Gene

Symbol
NPR3
HGNC
Name
natriuretic peptide receptor 3
HGNC
NCBI Gene ID
4883
NCBI Gene
HGNC ID
HGNC:7945
HGNC
Ensembl
ENSG00000113389
NCBI Gene
Aliases
ANP-C, ANPR-C, ANPRC, BOMOS, C5orf23, FLJ14054, GUCY2B, NPR-C, NPRC
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P17342Atrial natriuretic peptide receptor 35414Ensembl, GeneID, HGNC

Source UniProt

Patents40

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455060P17342Espacenet
EP 4650780 A22025-11-192435P17342Espacenet
EP 4641201 A22025-10-292017P17342Espacenet
JP 2025529142 A2025-09-042891P17342Espacenet
US 12371689 B22025-07-292891P17342Espacenet
JP 2025517969 A2025-06-122017P17342Espacenet
JP 2025517970 A2025-06-122435P17342Espacenet
JP 2025032204 A2025-03-1132454P17342Espacenet
EP 4461818 A22024-11-1332454P17342Espacenet
JP 2023058610 A2023-04-2532454P17342Espacenet

1 to 10 of 40

See all 40 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
CARPERITIDECHEMBL2104386Atrial natriuretic peptide receptor agonistAGONIST

Source ChEMBL

Trials3

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT00259038CARPERITIDEPHASE2ClinicalTrials.gov
NCT00212056CARPERITIDEClinicalTrials.gov
NCT00030121CARPERITIDEPHASE2ClinicalTrials.gov

NIH grants1,357

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNPR3 papersNewest fiscal year
P30CA056036Translational Research in Cancer112025
R01CA159859Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma62025
P30DK063491Diabetes Research Center (DRC)52025
R01AI089894Novel Antigen Identification for an enterotoxigenic E coli vaccine52025
ZIAHL006001Framingham Project/Levy52025
P30CA008748Cancer Center Support Grant42025
P30CA068485Cancer Center Support Grant42025
R01HL086694From GWAS loci to blood pressure genes, variants & mechanisms - Renewal42025
P30CA016672Cancer Center Support Grant32025
P30DK019525University of Pennsylvania Diabetes Research Center32025

1 to 10 of 1,357Source NIH's project files

See all 1,357 nih grants

Papers1,657

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Single-channel characteristics and regulation of endogenously expressed cation channels in human cardiac microvascular endothelial cells and human aortic endothelial cells.Biochim Biophys Acta Gen Subj202642805465PubTator, text miningPubMed
Construction and validation of a β-hydroxybutyrylation-related molecular model for predicting prognosis of papillary thyroid carcinoma.Transl Cancer Res202642724419PubTator, text miningPubMed
Nano-enabled natriuretic peptide therapy in post-myocardial infarction heart failure: from functional NP deficiency to dual-axis (cGMP-dependent and -independent) cardioprotection.Intern Emerg Med202642665772PubTator, text miningPubMed
Inhibitory mechanism of ANP on aldosterone production in human adrenocortical cells.Endocr Connect202642535457PubTator, text miningPubMed
Natriuretic peptide receptor C in cardiovascular-kidney-liver-metabolic syndrome: from natriuretic peptide deficiency to direct tissue signaling?Rev Endocr Metab Disord202642429916PubTator, text miningPubMed
Evaluating linaclotide for the treatment of irritable bowel syndrome with constipation in children and adolescents.Expert Opin Pharmacother202642425925PubTator, text miningPubMed
Barrier restoration as a therapeutic strategy for disorders of gut-brain interaction.Lancet Gastroenterol Hepatol202642413530PubTator, text miningPubMed
Identification and validation of novel diagnostic biomarkers across multiple tissues in osteoarthritis.Adv Clin Exp Med202642397093PubTator, text miningPubMed
Multi-omics profiling reveals an auxin-salicylic acid signaling hub driving flavonoid depletion and accelerated vigor loss in tetraploid Chinese cabbage seeds.Front Genet202642333093PubTator, text miningPubMed
Irritable Bowel Syndrome with Constipation: Diagnosis and Multisymptom Management Beyond Abdominal Pain and Bowel Movement Frequency: A Review.Adv Ther202642283961PubTator, text miningPubMed

1 to 10 of 1,657

See all 1,657 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4883

GET https://conductscience.org/api/genes/v1/4883/patents?page=2