Gene · 4883
NPR3: natriuretic peptide receptor 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. NPR3: natriuretic peptide receptor 3. Genes, record 4883. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4883
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P17342 | Atrial natriuretic peptide receptor 3 | 541 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents40
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 55060 | P17342 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2435 | P17342 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 2017 | P17342 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 2891 | P17342 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2891 | P17342 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 2017 | P17342 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2435 | P17342 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 32454 | P17342 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 32454 | P17342 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 32454 | P17342 | Espacenet |
1 to 10 of 40
See all 40 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| CARPERITIDE | CHEMBL2104386 | Atrial natriuretic peptide receptor agonist | AGONIST |
Source ChEMBL
Trials3
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT00259038 | CARPERITIDE | PHASE2 | ClinicalTrials.gov | |
| NCT00212056 | CARPERITIDE | ClinicalTrials.gov | ||
| NCT00030121 | CARPERITIDE | PHASE2 | ClinicalTrials.gov |
NIH grants1,357
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | NPR3 papers | Newest fiscal year |
|---|---|---|---|
| P30CA056036 | Translational Research in Cancer | 11 | 2025 |
| R01CA159859 | Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma | 6 | 2025 |
| P30DK063491 | Diabetes Research Center (DRC) | 5 | 2025 |
| R01AI089894 | Novel Antigen Identification for an enterotoxigenic E coli vaccine | 5 | 2025 |
| ZIAHL006001 | Framingham Project/Levy | 5 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 4 | 2025 |
| P30CA068485 | Cancer Center Support Grant | 4 | 2025 |
| R01HL086694 | From GWAS loci to blood pressure genes, variants & mechanisms - Renewal | 4 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 3 | 2025 |
| P30DK019525 | University of Pennsylvania Diabetes Research Center | 3 | 2025 |
1 to 10 of 1,357Source NIH's project files
See all 1,357 nih grantsPapers1,657
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Single-channel characteristics and regulation of endogenously expressed cation channels in human cardiac microvascular endothelial cells and human aortic endothelial cells. | Biochim Biophys Acta Gen Subj | 2026 | 42805465 | PubTator, text mining | PubMed |
| Construction and validation of a β-hydroxybutyrylation-related molecular model for predicting prognosis of papillary thyroid carcinoma. | Transl Cancer Res | 2026 | 42724419 | PubTator, text mining | PubMed |
| Nano-enabled natriuretic peptide therapy in post-myocardial infarction heart failure: from functional NP deficiency to dual-axis (cGMP-dependent and -independent) cardioprotection. | Intern Emerg Med | 2026 | 42665772 | PubTator, text mining | PubMed |
| Inhibitory mechanism of ANP on aldosterone production in human adrenocortical cells. | Endocr Connect | 2026 | 42535457 | PubTator, text mining | PubMed |
| Natriuretic peptide receptor C in cardiovascular-kidney-liver-metabolic syndrome: from natriuretic peptide deficiency to direct tissue signaling? | Rev Endocr Metab Disord | 2026 | 42429916 | PubTator, text mining | PubMed |
| Evaluating linaclotide for the treatment of irritable bowel syndrome with constipation in children and adolescents. | Expert Opin Pharmacother | 2026 | 42425925 | PubTator, text mining | PubMed |
| Barrier restoration as a therapeutic strategy for disorders of gut-brain interaction. | Lancet Gastroenterol Hepatol | 2026 | 42413530 | PubTator, text mining | PubMed |
| Identification and validation of novel diagnostic biomarkers across multiple tissues in osteoarthritis. | Adv Clin Exp Med | 2026 | 42397093 | PubTator, text mining | PubMed |
| Multi-omics profiling reveals an auxin-salicylic acid signaling hub driving flavonoid depletion and accelerated vigor loss in tetraploid Chinese cabbage seeds. | Front Genet | 2026 | 42333093 | PubTator, text mining | PubMed |
| Irritable Bowel Syndrome with Constipation: Diagnosis and Multisymptom Management Beyond Abdominal Pain and Bowel Movement Frequency: A Review. | Adv Ther | 2026 | 42283961 | PubTator, text mining | PubMed |
1 to 10 of 1,657
See all 1,657 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4883
GET https://conductscience.org/api/genes/v1/4883/patents?page=2