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Gene · 489

ATP2A3: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ATP2A3: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3. Genes, record 489. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/489

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Gene

Symbol
ATP2A3
HGNC
Name
ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
HGNC
NCBI Gene ID
489
NCBI Gene
HGNC ID
HGNC:813
HGNC
Ensembl
ENSG00000074370
NCBI Gene
Aliases
SERCA3
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q93084Sarcoplasmic/endoplasmic reticulum calcium ATPase 39990Ensembl, GeneID, HGNC

Source UniProt

Patents19

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1438222Q93084Espacenet
EP 4641201 A22025-10-2911980Q93084Espacenet
JP 2025517969 A2025-06-1211980Q93084Espacenet
JP 2025062604 A2025-04-147297Q93084Espacenet
JP 2025032204 A2025-03-1124967Q93084Espacenet
EP 4461818 A22024-11-1324967Q93084Espacenet
JP 2023058610 A2023-04-2524967Q93084Espacenet
US 11446398 B22022-09-207297Q93084Espacenet
US 11400116 B22022-08-023223Q93084Espacenet
JP 2022524081 A2022-04-27110268Q93084Espacenet

1 to 10 of 19

See all 19 patents

Drugs1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismAction
MIPSAGARGINCHEMBL3989865Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitorINHIBITOR

Source ChEMBL

Trials7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02876003MIPSAGARGINPHASE2ClinicalTrials.gov
NCT02607553MIPSAGARGINPHASE2ClinicalTrials.gov
NCT02381236MIPSAGARGINPHASE2ClinicalTrials.gov
NCT02082691MIPSAGARGINClinicalTrials.gov
NCT02067156MIPSAGARGINPHASE22024-05-21ClinicalTrials.gov
NCT01777594MIPSAGARGINPHASE2ClinicalTrials.gov
NCT01734681MIPSAGARGINPHASE2ClinicalTrials.gov

NIH grants1,661

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleATP2A3 papersNewest fiscal year
R01HL092321Regulation of Cardiac Calcium Transport112025
R01HL143816Membrane Micropeptides and Calcium Pump Allostery72025
T32AR007612Minnesota Muscle Training Program62025
P30DK020579Diabetes Research Center52025
U54GM104942West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health52025
P30CA016672Cancer Center Support Grant42025
P50AA011999Southern California Research Center for ALPD and Cirrhosis42025
R01DE014756Ca2+ and secretory dynamics in salivary acinar cells42025
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology32025
P30CA006927Comprehensive Cancer Center Program at Fox Chase32025

1 to 10 of 1,661Source NIH's project files

See all 1,661 nih grants

Papers2,442

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Bisphenol F induces intestinal epithelial injury through hsa_circ_0003655-mediated dual-axis disruption of cytoplasmic and organellar calcium homeostasis.Ecotoxicol Environ Saf202642801897PubTator, text miningPubMed
Inorganic polyphosphate chelates Ca2+ but cannot substitute for ATP as an energy source for SERCA.Biochem Biophys Rep202642774831PubTator, text miningPubMed
Sarcolipin is a Conformation-Dependent Regulator of the Sarcoplasmic Reticulum Calcium Pump SERCA.J Membr Biol202642745089PubTator, text miningPubMed
Heat shock protein 70 protects against peroxynitrite-induced inactivation of the cardiac sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2a).Free Radic Res202642678724PubTator, text miningPubMed
Targeting endoplasmic reticulum stress to attenuate cisplatin resistance in non-small cell lung cancer.Med Oncol202642635864PubTator, text miningPubMed
Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation.Circ Res202642594169PubTator, text miningPubMed
Identification and preliminary examination of prognostic genes linked to calcium metabolism in colorectal cancer.J Gastrointest Oncol202642434282PubTator, text miningPubMed
Calcium and TRPML-Mediated Autophagy: Implications in Cancer, Cardiovascular Diseases, and Cardio-Oncology.Cardiovasc Toxicol202642414743PubTator, text miningPubMed
Structural Basis of SERCA Inhibition by Derivatives of di-tert-butylhydroquinone Revealed by X-ray Crystallography.J Membr Biol202642371092PubTator, text miningPubMed
Thapsigargin-induced autophagic flux impairment and inflammation are potentiated by CLN3 deficiency and alleviated by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in human ARPE-19 cells.Biochem Biophys Res Commun202642308764PubTator, text miningPubMed

1 to 10 of 2,442

See all 2,442 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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