Gene · 489
ATP2A3: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ATP2A3: ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3. Genes, record 489. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/489
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q93084 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 | 999 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents19
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 38222 | Q93084 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 11980 | Q93084 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 11980 | Q93084 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 7297 | Q93084 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 24967 | Q93084 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 24967 | Q93084 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 24967 | Q93084 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 7297 | Q93084 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 3223 | Q93084 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 110268 | Q93084 | Espacenet |
1 to 10 of 19
See all 19 patentsDrugs1
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
| Drug | ChEMBL ID | Mechanism | Action |
|---|---|---|---|
| MIPSAGARGIN | CHEMBL3989865 | Sarcoplasmic/endoplasmic reticulum calcium ATPase inhibitor | INHIBITOR |
Source ChEMBL
Trials7
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT02876003 | MIPSAGARGIN | PHASE2 | ClinicalTrials.gov | |
| NCT02607553 | MIPSAGARGIN | PHASE2 | ClinicalTrials.gov | |
| NCT02381236 | MIPSAGARGIN | PHASE2 | ClinicalTrials.gov | |
| NCT02082691 | MIPSAGARGIN | ClinicalTrials.gov | ||
| NCT02067156 | MIPSAGARGIN | PHASE2 | 2024-05-21 | ClinicalTrials.gov |
| NCT01777594 | MIPSAGARGIN | PHASE2 | ClinicalTrials.gov | |
| NCT01734681 | MIPSAGARGIN | PHASE2 | ClinicalTrials.gov |
NIH grants1,661
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ATP2A3 papers | Newest fiscal year |
|---|---|---|---|
| R01HL092321 | Regulation of Cardiac Calcium Transport | 11 | 2025 |
| R01HL143816 | Membrane Micropeptides and Calcium Pump Allostery | 7 | 2025 |
| T32AR007612 | Minnesota Muscle Training Program | 6 | 2025 |
| P30DK020579 | Diabetes Research Center | 5 | 2025 |
| U54GM104942 | West Virginia Clinical and Translational Science Institute: A Statewide Organization Building Research Excellence and Engaging Communities to Improve Health | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P50AA011999 | Southern California Research Center for ALPD and Cirrhosis | 4 | 2025 |
| R01DE014756 | Ca2+ and secretory dynamics in salivary acinar cells | 4 | 2025 |
| P01HL141084 | Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology | 3 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 3 | 2025 |
1 to 10 of 1,661Source NIH's project files
See all 1,661 nih grantsPapers2,442
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Bisphenol F induces intestinal epithelial injury through hsa_circ_0003655-mediated dual-axis disruption of cytoplasmic and organellar calcium homeostasis. | Ecotoxicol Environ Saf | 2026 | 42801897 | PubTator, text mining | PubMed |
| Inorganic polyphosphate chelates Ca2+ but cannot substitute for ATP as an energy source for SERCA. | Biochem Biophys Rep | 2026 | 42774831 | PubTator, text mining | PubMed |
| Sarcolipin is a Conformation-Dependent Regulator of the Sarcoplasmic Reticulum Calcium Pump SERCA. | J Membr Biol | 2026 | 42745089 | PubTator, text mining | PubMed |
| Heat shock protein 70 protects against peroxynitrite-induced inactivation of the cardiac sarco(endo)plasmic reticulum Ca2+-ATPase (SERCA2a). | Free Radic Res | 2026 | 42678724 | PubTator, text mining | PubMed |
| Targeting endoplasmic reticulum stress to attenuate cisplatin resistance in non-small cell lung cancer. | Med Oncol | 2026 | 42635864 | PubTator, text mining | PubMed |
| Extracellular Vesicles in Cardiovascular Disease: Intercellular Signaling, Liquid Biopsy Biomarkers, and Therapeutic Translation. | Circ Res | 2026 | 42594169 | PubTator, text mining | PubMed |
| Identification and preliminary examination of prognostic genes linked to calcium metabolism in colorectal cancer. | J Gastrointest Oncol | 2026 | 42434282 | PubTator, text mining | PubMed |
| Calcium and TRPML-Mediated Autophagy: Implications in Cancer, Cardiovascular Diseases, and Cardio-Oncology. | Cardiovasc Toxicol | 2026 | 42414743 | PubTator, text mining | PubMed |
| Structural Basis of SERCA Inhibition by Derivatives of di-tert-butylhydroquinone Revealed by X-ray Crystallography. | J Membr Biol | 2026 | 42371092 | PubTator, text mining | PubMed |
| Thapsigargin-induced autophagic flux impairment and inflammation are potentiated by CLN3 deficiency and alleviated by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) in human ARPE-19 cells. | Biochem Biophys Res Commun | 2026 | 42308764 | PubTator, text mining | PubMed |
1 to 10 of 2,442
See all 2,442 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/489
GET https://conductscience.org/api/genes/v1/489/patents