Gene · 4891
SLC11A2: solute carrier family 11 member 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. SLC11A2: solute carrier family 11 member 2. Genes, record 4891. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4891
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P49281 | Natural resistance-associated macrophage protein 2 | 568 | 7 | Ensembl, GeneID, HGNC |
Source UniProt
Patents35
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| EP 4650780 A2 | 2025-11-19 | 16462 | P49281 | Espacenet |
| JP 2025529142 A | 2025-09-04 | 3987 | P49281 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 3987 | P49281 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 16462 | P49281 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 80332 | P49281 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 80338 | P49281 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 80346 | P49281 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 183303 | P49281 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 183309 | P49281 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 183317 | P49281 | Espacenet |
1 to 10 of 35
See all 35 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,643
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | SLC11A2 papers | Newest fiscal year |
|---|---|---|---|
| R01ES010563 | Mechanisms of Manganese Neurotoxicity | 48 | 2025 |
| R01ES007331 | Mechanisms of Methylmercury Induced Neuronal Toxicity | 27 | 2025 |
| R01CA148828 | The role of HIF2alpha in colon carcinogenesis | 10 | 2025 |
| P30DK040561 | Boston Area Nutrition Obesity Research Center (NORC) | 9 | 2025 |
| T32ES007028 | Training Program in Environmental Toxicology | 9 | 2025 |
| R01DK095201 | Control of iron absorption by intestinal HIF2 in iron and hematological disorders | 8 | 2025 |
| ZIAHD001602 | Regulation Of Intracellular Iron Metabolism | 7 | 2025 |
| P30ES001247 | Environmental Agents as Modulators of Disease Processes | 6 | 2025 |
| R01AI143673 | Structure-Function Analysis of Mxra8 Interaction with Alphaviruses | 6 | 2025 |
| ZIADK054510 | Identification of human genes of iron homeostasis | 6 | 2025 |
1 to 10 of 1,643Source NIH's project files
See all 1,643 nih grantsPapers3,548
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Age-Related Changes in Differential Corneal Thickness and Their Correlation with With-the-Rule and Against-the-Rule Corneal Astigmatism. | Ophthalmic Physiol Opt | 2026 | 42821186 | PubTator, text mining | PubMed |
| (S)-SA, a bioactive flavonoid from Dalbergiae Odoriferae Lignum, alleviates cerebral ischemia-reperfusion injury via SLC11A2-mediated ferroptosis inhibition. | Phytomedicine | 2026 | 42731451 | PubTator, text mining | PubMed |
| Integrated multi-omics analyses identify an RAS-SLC11A2-associated molecular framework linking iron metabolism with PCOS-related cardiometabolic risk. | Clin Exp Hypertens | 2026 | 42678751 | PubTator, text mining | PubMed |
| Telmisartan Repurposing Targets Novel Biomarkers for Precision Colorectal Cancer Therapy. | Pharmaceutics | 2026 | 42654148 | PubTator, text mining | PubMed |
| Iron-endoplasmic reticulum-extracellular matrix axis regulates cancer cell invasion. | bioRxiv | 2026 | 42620126 | PubTator, text mining | PubMed |
| Beyond bioavailability: dual-source iron improves absorption and cellular handling. | Front Nutr | 2026 | 42459812 | PubTator, text mining | PubMed |
| Duodenal dysbiosis is linked to altered ferroportin related transcriptomics programs in iron deficiency anemia. | Front Nutr | 2026 | 42459794 | PubTator, text mining | PubMed |
| Non-transferrin-bound iron uptake by cardiomyocytes. | J Mol Med (Berl) | 2026 | 42400642 | PubTator, text mining | PubMed |
| Research Progress In Acupuncture For Parkinson's Disease: Insights Into The Mitochondrial Ferroptosis Pathway. | J Vis Exp | 2026 | 42371862 | PubTator, text mining | PubMed |
| An N-terminal amphipathic helix governs activity and conformational dynamics of Nramp metal transporters. | J Biol Chem | 2026 | 42264089 | PubTator, text mining | PubMed |
1 to 10 of 3,548
See all 3,548 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4891
GET https://conductscience.org/api/genes/v1/4891/patents?page=2