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Gene · 4891

SLC11A2: solute carrier family 11 member 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. SLC11A2: solute carrier family 11 member 2. Genes, record 4891. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4891

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Gene

Symbol
SLC11A2
HGNC
Name
solute carrier family 11 member 2
HGNC
NCBI Gene ID
4891
NCBI Gene
HGNC ID
HGNC:10908
HGNC
Ensembl
ENSG00000110911
NCBI Gene
Aliases
AHMIO1, DCT1, DMT-1, DMT1, FLJ37416, NRAMP2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P49281Natural resistance-associated macrophage protein 25687Ensembl, GeneID, HGNC

Source UniProt

Patents35

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4650780 A22025-11-1916462P49281Espacenet
JP 2025529142 A2025-09-043987P49281Espacenet
US 12371689 B22025-07-293987P49281Espacenet
JP 2025517970 A2025-06-1216462P49281Espacenet
US 11446398 B22022-09-2080332P49281Espacenet
US 11446398 B22022-09-2080338P49281Espacenet
US 11446398 B22022-09-2080346P49281Espacenet
JP 2022524081 A2022-04-27183303P49281Espacenet
JP 2022524081 A2022-04-27183309P49281Espacenet
JP 2022524081 A2022-04-27183317P49281Espacenet

1 to 10 of 35

See all 35 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,643

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleSLC11A2 papersNewest fiscal year
R01ES010563Mechanisms of Manganese Neurotoxicity482025
R01ES007331Mechanisms of Methylmercury Induced Neuronal Toxicity272025
R01CA148828The role of HIF2alpha in colon carcinogenesis102025
P30DK040561Boston Area Nutrition Obesity Research Center (NORC)92025
T32ES007028Training Program in Environmental Toxicology92025
R01DK095201Control of iron absorption by intestinal HIF2 in iron and hematological disorders82025
ZIAHD001602Regulation Of Intracellular Iron Metabolism72025
P30ES001247Environmental Agents as Modulators of Disease Processes62025
R01AI143673Structure-Function Analysis of Mxra8 Interaction with Alphaviruses62025
ZIADK054510Identification of human genes of iron homeostasis62025

1 to 10 of 1,643Source NIH's project files

See all 1,643 nih grants

Papers3,548

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Age-Related Changes in Differential Corneal Thickness and Their Correlation with With-the-Rule and Against-the-Rule Corneal Astigmatism.Ophthalmic Physiol Opt202642821186PubTator, text miningPubMed
(S)-SA, a bioactive flavonoid from Dalbergiae Odoriferae Lignum, alleviates cerebral ischemia-reperfusion injury via SLC11A2-mediated ferroptosis inhibition.Phytomedicine202642731451PubTator, text miningPubMed
Integrated multi-omics analyses identify an RAS-SLC11A2-associated molecular framework linking iron metabolism with PCOS-related cardiometabolic risk.Clin Exp Hypertens202642678751PubTator, text miningPubMed
Telmisartan Repurposing Targets Novel Biomarkers for Precision Colorectal Cancer Therapy.Pharmaceutics202642654148PubTator, text miningPubMed
Iron-endoplasmic reticulum-extracellular matrix axis regulates cancer cell invasion.bioRxiv202642620126PubTator, text miningPubMed
Beyond bioavailability: dual-source iron improves absorption and cellular handling.Front Nutr202642459812PubTator, text miningPubMed
Duodenal dysbiosis is linked to altered ferroportin related transcriptomics programs in iron deficiency anemia.Front Nutr202642459794PubTator, text miningPubMed
Non-transferrin-bound iron uptake by cardiomyocytes.J Mol Med (Berl)202642400642PubTator, text miningPubMed
Research Progress In Acupuncture For Parkinson's Disease: Insights Into The Mitochondrial Ferroptosis Pathway.J Vis Exp202642371862PubTator, text miningPubMed
An N-terminal amphipathic helix governs activity and conformational dynamics of Nramp metal transporters.J Biol Chem202642264089PubTator, text miningPubMed

1 to 10 of 3,548

See all 3,548 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4891

GET https://conductscience.org/api/genes/v1/4891/patents?page=2