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Gene · 4900

NRGN: neurogranin

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NRGN: neurogranin. Genes, record 4900. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4900

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Gene

Symbol
NRGN
HGNC
Name
neurogranin
HGNC
NCBI Gene ID
4900
NCBI Gene
HGNC ID
HGNC:8000
HGNC
Ensembl
ENSG00000154146
NCBI Gene
Aliases
RC3, hng
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q92686Neurogranin780Ensembl, GeneID, HGNC

Source UniProt

Patents73

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
US 12560619 B22026-02-2421Q92686Espacenet
EP 4679096 A12026-01-1430Q92686Espacenet
EP 4679096 A12026-01-1431Q92686Espacenet
EP 4679096 A12026-01-1433Q92686Espacenet
EP 4679096 A12026-01-1436Q92686Espacenet
EP 4679097 A12026-01-1430Q92686Espacenet
EP 4679097 A12026-01-1431Q92686Espacenet
EP 4679097 A12026-01-1433Q92686Espacenet
EP 4679097 A12026-01-1436Q92686Espacenet
JP 2026004568 A2026-01-1455442Q92686Espacenet

1 to 10 of 73

See all 73 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,780

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNRGN papersNewest fiscal year
R01AG027161Wisconsin Registry for Alzheimer's Prevention242025
P01AG026276Antecedent Biomarkers for Alzheimer Disease: The Adult Children Study212025
R01AG021155The Longitudinal Course of Imaging Biomarkers in People At Risk for Alzheimer’s Disease212025
P20GM109025Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) CNTN - Resubmission202025
P30AG062715Wisconsin Alzheimer's Disease Research Center202025
P30AG066444Alzheimer's Disease Research Center172025
U19AG032438Bridge Funding for Dominantly Inherited Alzheimer Network112025
U19AG024904Alzheimer's Disease Neuroimaging Initiative (ADNI4)102025
P30AG062421Massachusetts Alzheimer's Disease Research Center (MADRC)72025
U24AG021886National Centralized Repository for Alzheimer's Disease and Related Dementias (NCRAD)72025

1 to 10 of 1,780Source NIH's project files

See all 1,780 nih grants

Papers2,084

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Dynamic changes in plasma biomarkers of Alzheimer's disease in patients treated with lecanemab: a longitudinal cohort study.Lancet Neurol202642785333PubTator, text miningPubMed
Proteomic markers linking anxiety phenotypes to Alzheimer's disease risk: a multi-analyte proteomic analysis.medRxiv202642779925PubTator, text miningPubMed
Altered synaptic and astrocytic proteins in Lewy body disorders associated with GBA mutations.Brain Commun202642582587PubTator, text miningPubMed
Semaglutide as a potential neuroprotective agent for neurological and neurodegenerative disorders: Mechanisms, preclinical evidence, and translational challenges and opportunities.Mol Biol Rep202642573665PubTator, text miningPubMed
Harnessing Affinity Tags for Recombinant Protein Purification: Concepts, Methods, and Troubleshooting.Methods Mol Biol202642562985PubTator, text miningPubMed
Biochemical modulators of synaptic plasticity: New horizons in Alzheimer's disease treatment.J Alzheimers Dis202642489531PubTator, text miningPubMed
NRGN inhibits CD8⁺ T cell effector function by downregulating MHC-I expression through the FMR1-IRF8 axis in hepatocellular carcinoma.J Exp Clin Cancer Res202642458540PubTator, text miningPubMed
Higher physical activity levels mitigate synaptic protein loss and cognitive deterioration in aging and in Alzheimer's disease: a 10-year longitudinal study.Mol Biomed202642455424PubTator, text miningPubMed
Glial molecular signatures as a liquid biopsy marker in Alzheimer's disease diagnosis.Int Rev Neurobiol202642442917PubTator, text miningPubMed
Value of synaptic proteins as biomarkers in amyotrophic lateral sclerosis.Brain Commun202642404435PubTator, text miningPubMed

1 to 10 of 2,084

See all 2,084 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4900

GET https://conductscience.org/api/genes/v1/4900/patents?page=2