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Gene · 4905

NSF: N-ethylmaleimide sensitive factor, vesicle fusing ATPase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NSF: N-ethylmaleimide sensitive factor, vesicle fusing ATPase. Genes, record 4905. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4905

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Gene

Symbol
NSF
HGNC
Name
N-ethylmaleimide sensitive factor, vesicle fusing ATPase
HGNC
NCBI Gene ID
4905
NCBI Gene
HGNC ID
HGNC:8016
HGNC
Ensembl
ENSG00000073969
NCBI Gene
Aliases
DEE96, SEC18, SKD2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P46459Vesicle-fusing ATPase7441Ensembl, GeneID, HGNC

Source UniProt

Patents28

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
EP 4689130 A22026-02-11132P46459Espacenet
JP 2026004568 A2026-01-1455212P46459Espacenet
EP 4650780 A22025-11-1911577P46459Espacenet
EP 4641201 A22025-10-2912144P46459Espacenet
JP 2025517969 A2025-06-1212144P46459Espacenet
JP 2025517970 A2025-06-1211577P46459Espacenet
US 11446398 B22022-09-2055904P46459Espacenet
US 11446398 B22022-09-2055911P46459Espacenet
US 11446398 B22022-09-2055912P46459Espacenet
US 11371991 B22022-06-281P46459Espacenet

1 to 10 of 28

See all 28 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,862

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNSF papersNewest fiscal year
R35GM118037Mechanisms of Membrane Fusion112025
R01MH063105Molecular mechanisms of synaptic neurotransmitter release82025
R01HL016037Molecular Regulation of Cardiovascular 7 TM Receptors62025
P01AG019724Frontotemporal Dementia: Genes, Images, and Emotions42025
P30CA008748Cancer Center Support Grant42025
P30CA016672Cancer Center Support Grant42025
P30ES006694Southwest Environmental Health Sciences Center42025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control42025
R01GM083144Characterization of mammalian COG complex-interacting Golgi trafficking machinery42025
R01HD038082Sperm Ca2+ signaling and energy pathways in basic science and ART42025

1 to 10 of 1,862Source NIH's project files

See all 1,862 nih grants

Papers1,983

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Elucidating shared genetic signals between type 2 diabetes and three neurodegenerative dementia phenotypes.HGG Adv202642681870PubTator, text miningPubMed
NSF gene variants cause developmental and epileptic encephalopathy 96: expanding genotype and phenotypic spectrum with prenatal-onset features.Front Genet202642609877PubTator, text miningPubMed
Yorkie/YAP Interactors: Fine-Tuning the Hippo Pathway Output.Cold Spring Harb Perspect Biol202642575696PubTator, text miningPubMed
Supervised Exercise Intervention Restores Physical Activity and MultiOMIC-Derived Frailty Biomarkers in Older Adults.J Cachexia Sarcopenia Muscle202642571782PubTator, text miningPubMed
Characterizing the impact of plasma protein levels on human brain structure and disorders leveraging integrative multi-omics analysis.medRxiv202642528609PubTator, text miningPubMed
A vesicular trafficking pathway mediated by N-ethylmaleimide-sensitive factor governs integrin maturation and podocyte integrity.Kidney Int202642492856PubTator, text miningPubMed
Integrative multi-omics analysis identifies a mitochondrial dysfunction-associated diagnostic signature, molecular subtypes, and drug repurposing candidates for keloid disease.Burns202642413388PubTator, text miningPubMed
HiFiMAP: High-resolution fast identity-by-descent mapping test.medRxiv202642180323PubTator, text miningPubMed
The RBFOX1 regulatory gene network contributes to major depressive disorder, anxiety, irritability and neuroticism.Prog Neuropsychopharmacol Biol Psychiatry202642034278PubTator, text miningPubMed
NSF is required for diverse endocytic modes by promoting fusion and fission pore closure in secretory cells.iScience202642004027PubTator, text miningPubMed

1 to 10 of 1,983

See all 1,983 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4905

GET https://conductscience.org/api/genes/v1/4905/patents?page=2