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NT5E: 5'-nucleotidase ecto

1 protein, 180 patents, 1 drug, 25 trials, 5,891 NIH grants and 20,687 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNT5EHGNC
Name5'-nucleotidase ectoHGNC
NCBI Gene ID4907NCBI Gene
HGNC IDHGNC:8021HGNC
EnsemblENSG00000135318NCBI Gene
AliasesCALJA, CD73, E5NT, NT, NT5, NTE, eN, eNTNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P215895'-nucleotidase57451Ensembl, GeneID, HGNCUniProt

Patents 180

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026171886 A12026-08-203P21589Espacenet
US 12630648 B22026-05-19148P21589Espacenet
JP 2026062933 A2026-04-10148P21589Espacenet
WO 2026017877 A12026-01-2240P21589Espacenet
JP 2026004568 A2026-01-1435820P21589Espacenet
EP 4650780 A22025-11-191645P21589Espacenet
WO 2025233264 A12025-11-131P21589Espacenet
JP 2025147176 A2025-10-069606P21589Espacenet
US 12414984 B22025-09-1641P21589Espacenet
JP 2025529142 A2025-09-042916P21589Espacenet

Drugs 1

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
OLECLUMABCHEMBL39900165'-nucleotidase inhibitorINHIBITORChEMBL

Trials 25

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07146230OLECLUMABPHASE2ClinicalTrials.gov
NCT06606847OLECLUMABPHASE2ClinicalTrials.gov
NCT06060405OLECLUMABPHASE2ClinicalTrials.gov
NCT05221840OLECLUMABPHASE3ClinicalTrials.gov
NCT05061550OLECLUMABPHASE2ClinicalTrials.gov
NCT04940286OLECLUMABPHASE2ClinicalTrials.gov
NCT04668300OLECLUMABPHASE2ClinicalTrials.gov
NCT04262388OLECLUMABPHASE2ClinicalTrials.gov
NCT04262375OLECLUMABPHASE2ClinicalTrials.gov
NCT04145193OLECLUMABPHASE2ClinicalTrials.gov

NIH grants 5891

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant432,025NIH's project files
P30CA008748Cancer Center Support Grant342,025NIH's project files
P30CA047904Cancer Center Support Grant342,025NIH's project files
P30CA006973Regional Oncology Research Center182,025NIH's project files
ZIADK031117Development of Drugs Acting at Adenosine Receptors162,025NIH's project files
P01AI045897A Tolerance Approach to Xenotransplantation152,025NIH's project files
R01DK095491Indole dysbiosis and mucosal inflammation152,025NIH's project files
P30CA014520UW Comprehensive Cancer Center Support122,025NIH's project files
P30CA015704Cancer Center Support Grant122,025NIH's project files
P30CA077598Cancer Center Support Grant122,025NIH's project files

Papers 20687

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42817134PubTator, text miningPubMed
42815694PubTator, text miningPubMed
42804095PubTator, text miningPubMed
42798844PubTator, text miningPubMed
42797417PubTator, text miningPubMed
42794664PubTator, text miningPubMed
42789078PubTator, text miningPubMed
42782994PubTator, text miningPubMed
42782738PubTator, text miningPubMed
42775202PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license