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NTRK1: neurotrophic receptor tyrosine kinase 1

1 protein, 102 patents, 18 drugs, 342 trials, 4,719 NIH grants and 11,764 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNTRK1HGNC
Nameneurotrophic receptor tyrosine kinase 1HGNC
NCBI Gene ID4914NCBI Gene
HGNC IDHGNC:8031HGNC
EnsemblENSG00000198400NCBI Gene
AliasesMTC, TRK, TRK1, TRKA, Trk-A, p140-TrkANCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P04629High affinity nerve growth factor receptor79666Ensembl, GeneID, HGNCUniProt

Patents 102

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4716738 A12026-04-0141P04629Espacenet
JP 2026004568 A2026-01-1455581P04629Espacenet
JP 2025172069 A2025-11-20635P04629Espacenet
EP 4650780 A22025-11-1915417P04629Espacenet
WO 2025235931 A22025-11-1310P04629Espacenet
EP 4641201 A22025-10-2918426P04629Espacenet
JP 2025529142 A2025-09-042918P04629Espacenet
US 12371689 B22025-07-292918P04629Espacenet
JP 2025517969 A2025-06-1218426P04629Espacenet
JP 2025517970 A2025-06-1215417P04629Espacenet

Drugs 18

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALTIRATINIBCHEMBL3545365Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
AZD-6918CHEMBL3545298Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
AZD-7451CHEMBL3659497Nerve growth factor receptor Trk-A inhibitorINHIBITORChEMBL
CENEGERMINCHEMBL4297852Neurotrophic tyrosine kinase receptor agonistAGONISTChEMBL
CEP-2563CHEMBL6069183Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
CEP-2563 DIHYDROCHLORIDECHEMBL6067987Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
ENTRECTINIBCHEMBL1983268Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
GZ-389988CHEMBL3673452Nerve growth factor receptor Trk-A inhibitorINHIBITORChEMBL
LAROTRECTINIBCHEMBL3889654Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
LAROTRECTINIB SULFATECHEMBL3989939Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL

Trials 342

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07599007REPOTRECTINIBClinicalTrials.gov
NCT07559864REGORAFENIBPHASE2ClinicalTrials.gov
NCT07537985REGORAFENIBClinicalTrials.gov
NCT07514455REGORAFENIBPHASE2ClinicalTrials.gov
NCT07514429REGORAFENIBPHASE2ClinicalTrials.gov
NCT07501351REGORAFENIBPHASE2ClinicalTrials.gov
NCT07495579REGORAFENIBPHASE2ClinicalTrials.gov
NCT07463248REGORAFENIBPHASE2ClinicalTrials.gov
NCT07379047REGORAFENIBPHASE2/PHASE3ClinicalTrials.gov
NCT07343791REGORAFENIBEARLY_PHASE1ClinicalTrials.gov

NIH grants 4719

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant2092,025NIH's project files
P30CA016672Cancer Center Support Grant672,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant232,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)222,025NIH's project files
P50CA217694SPORE in Soft Tissue Sarcoma162,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant132,025NIH's project files
T32CA009207Investigational Cancer Therapeutics Training Program (ICTTP)132,025NIH's project files
P30CA006973Regional Oncology Research Center122,025NIH's project files
P30CA016058Cancer Center Support Grant122,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award102,025NIH's project files

Papers 11764

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42819332PubTator, text miningPubMed
42819214PubTator, text miningPubMed
42808379PubTator, text miningPubMed
42804425PubTator, text miningPubMed
42800594PubTator, text miningPubMed
42800165PubTator, text miningPubMed
42792846PubTator, text miningPubMed
42781069PubTator, text miningPubMed
42771979PubTator, text miningPubMed
42764141PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license