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NTRK2: neurotrophic receptor tyrosine kinase 2

1 protein, 115 patents, 14 drugs, 79 trials, 5,424 NIH grants and 10,885 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNTRK2HGNC
Nameneurotrophic receptor tyrosine kinase 2HGNC
NCBI Gene ID4915NCBI Gene
HGNC IDHGNC:8032HGNC
EnsemblENSG00000148053NCBI Gene
AliasesDEE58, EIEE58, GP145-TrkB, OBHD, TRKB, trk-BNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q16620BDNF/NT-3 growth factors receptor8229Ensembl, GeneID, HGNCUniProt

Patents 115

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026220148 A12026-10-221Q16620Espacenet
JP 2026004568 A2026-01-1455584Q16620Espacenet
JP 2026004568 A2026-01-1455587Q16620Espacenet
KR 1020250142340 A2025-09-302Q16620Espacenet
JP 2025529142 A2025-09-042919Q16620Espacenet
US 12371689 B22025-07-292919Q16620Espacenet
WO 2025062271 A12025-03-2749Q16620Espacenet
WO 2025051360 A12025-03-133Q16620Espacenet
JP 2024009849 A2024-01-2375Q16620Espacenet
EP 4299732 A22024-01-0375Q16620Espacenet

Drugs 14

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALTIRATINIBCHEMBL3545365Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
AZD-6918CHEMBL3545298Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
AZD-7451CHEMBL3659497Neurotrophic tyrosine kinase receptor type 2 inhibitorINHIBITORChEMBL
CENEGERMINCHEMBL4297852Neurotrophic tyrosine kinase receptor agonistAGONISTChEMBL
CEP-2563CHEMBL6069183Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
CEP-2563 DIHYDROCHLORIDECHEMBL6067987Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
ENTRECTINIBCHEMBL1983268Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
LAROTRECTINIBCHEMBL3889654Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
LAROTRECTINIB SULFATECHEMBL3989939Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
LESTAURTINIBCHEMBL603469Neurotrophic tyrosine kinase receptor type 2 inhibitorINHIBITORChEMBL

Trials 79

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07599007REPOTRECTINIBClinicalTrials.gov
NCT07199010TALETRECTINIBClinicalTrials.gov
NCT07008287TALETRECTINIBClinicalTrials.gov
NCT06841874TALETRECTINIBClinicalTrials.gov
NCT06694129ENTRECTINIBClinicalTrials.gov
NCT06564324TALETRECTINIBPHASE3ClinicalTrials.gov
NCT06563999LAROTRECTINIBPHASE2ClinicalTrials.gov
NCT06552234REPOTRECTINIBPHASE2ClinicalTrials.gov
NCT06528691ENTRECTINIBPHASE2ClinicalTrials.gov
NCT06482086ENTRECTINIBPHASE2ClinicalTrials.gov

NIH grants 5424

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant802,025NIH's project files
P30CA016672Cancer Center Support Grant282,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant152,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award142,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)132,025NIH's project files
R01HL056470Neonatal Modulation of Airway Contractility132,025NIH's project files
ZIAMH002927Neurobiology and Target Validation of Novel Therapeutic Agents in Mood Disorders122,025NIH's project files
P30CA006973Regional Oncology Research Center112,025NIH's project files
ZIAMH002857Glutamatergic Modulators for Rapid and Sustained Antidepressant Effect112,025NIH's project files
ZIABC010390Role of Neurotrophins in the Development of the Mammalian Nervous System102,025NIH's project files

Papers 10885

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42818607PubTator, text miningPubMed
42818074PubTator, text miningPubMed
42805569PubTator, text miningPubMed
42804425PubTator, text miningPubMed
42800594PubTator, text miningPubMed
42794483PubTator, text miningPubMed
42793384PubTator, text miningPubMed
42792846PubTator, text miningPubMed
42780285PubTator, text miningPubMed
42767275PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license