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NTRK3: neurotrophic receptor tyrosine kinase 3

1 protein, 67 patents, 14 drugs, 79 trials, 2,289 NIH grants and 5,230 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolNTRK3HGNC
Nameneurotrophic receptor tyrosine kinase 3HGNC
NCBI Gene ID4916NCBI Gene
HGNC IDHGNC:8033HGNC
EnsemblENSG00000140538NCBI Gene
AliasesGP145-TrkC, TRKC, gp145(trkC)NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q16288NT-3 growth factor receptor8395Ensembl, GeneID, HGNCUniProt

Patents 67

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1455595Q16288Espacenet
EP 4650780 A22025-11-197842Q16288Espacenet
EP 4641201 A22025-10-297933Q16288Espacenet
JP 2025529142 A2025-09-042920Q16288Espacenet
US 12371689 B22025-07-292920Q16288Espacenet
JP 2025517969 A2025-06-127933Q16288Espacenet
JP 2025517970 A2025-06-127842Q16288Espacenet
JP 2024037938 A2024-03-193Q16288Espacenet
US 11484535 B22022-11-013Q16288Espacenet
US 11446398 B22022-09-2056702Q16288Espacenet

Drugs 14

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALTIRATINIBCHEMBL3545365Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
AZD-6918CHEMBL3545298Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
AZD-7451CHEMBL3659497NT-3 growth factor receptor inhibitorINHIBITORChEMBL
CENEGERMINCHEMBL4297852Neurotrophic tyrosine kinase receptor agonistAGONISTChEMBL
CEP-2563CHEMBL6069183Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
CEP-2563 DIHYDROCHLORIDECHEMBL6067987Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
ENTRECTINIBCHEMBL1983268Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
LAROTRECTINIBCHEMBL3889654Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
LAROTRECTINIB SULFATECHEMBL3989939Neurotrophic tyrosine kinase receptor inhibitorINHIBITORChEMBL
LESTAURTINIBCHEMBL603469NT-3 growth factor receptor inhibitorINHIBITORChEMBL

Trials 79

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07599007REPOTRECTINIBClinicalTrials.gov
NCT07199010TALETRECTINIBClinicalTrials.gov
NCT07008287TALETRECTINIBClinicalTrials.gov
NCT06841874TALETRECTINIBClinicalTrials.gov
NCT06694129ENTRECTINIBClinicalTrials.gov
NCT06564324TALETRECTINIBPHASE3ClinicalTrials.gov
NCT06563999LAROTRECTINIBPHASE2ClinicalTrials.gov
NCT06552234REPOTRECTINIBPHASE2ClinicalTrials.gov
NCT06528691ENTRECTINIBPHASE2ClinicalTrials.gov
NCT06482086ENTRECTINIBPHASE2ClinicalTrials.gov

NIH grants 2289

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant1552,025NIH's project files
P30CA016672Cancer Center Support Grant442,025NIH's project files
P50CA217694SPORE in Soft Tissue Sarcoma172,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)152,025NIH's project files
P30CA006973Regional Oncology Research Center112,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant112,025NIH's project files
P30CA076292Moffitt Cancer Center Support Grant92,025NIH's project files
P01CA096832NORMAL & NEOPLASTIC GROWTH IN THE BRAIN82,025NIH's project files
T32CA009207Investigational Cancer Therapeutics Training Program (ICTTP)82,025NIH's project files
P30CA047904Cancer Center Support Grant72,025NIH's project files

Papers 5230

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42808379PubTator, text miningPubMed
42804425PubTator, text miningPubMed
42801116PubTator, text miningPubMed
42800594PubTator, text miningPubMed
42754357PubTator, text miningPubMed
42748906PubTator, text miningPubMed
42748630PubTator, text miningPubMed
42734618PubTator, text miningPubMed
42729469PubTator, text miningPubMed
42729323PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license