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Gene · 4926

NUMA1: nuclear mitotic apparatus protein 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. NUMA1: nuclear mitotic apparatus protein 1. Genes, record 4926. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4926

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Gene

Symbol
NUMA1
HGNC
Name
nuclear mitotic apparatus protein 1
HGNC
NCBI Gene ID
4926
NCBI Gene
HGNC ID
HGNC:8059
HGNC
Ensembl
ENSG00000137497
NCBI Gene
Aliases
NMP-22, NUMA
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q14980Nuclear mitotic apparatus protein 12,1155Ensembl, GeneID, HGNC

Source UniProt

Patents27

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456059Q14980Espacenet
EP 4650780 A22025-11-1911055Q14980Espacenet
EP 4641201 A22025-10-2911490Q14980Espacenet
JP 2025531266 A2025-09-193Q14980Espacenet
EP 4587819 A22025-07-233Q14980Espacenet
JP 2025517969 A2025-06-1211490Q14980Espacenet
JP 2025517970 A2025-06-1211055Q14980Espacenet
JP 2024009871 A2024-01-2398Q14980Espacenet
US 11860162 B22024-01-021227Q14980Espacenet
EP 4223770 A22023-08-0966Q14980Espacenet

1 to 10 of 27

See all 27 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,480

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleNUMA1 papersNewest fiscal year
P30CA016672Cancer Center Support Grant112025
P30CA008748Cancer Center Support Grant82025
P30CA021765Cancer Center Support Grant (CCSG)62025
P30CA047904Cancer Center Support Grant62025
R35GM136420Emergent mechanics of mammalian chromosome segregation62025
P30CA016087Cancer Center Support Grant52025
P30CA014520UW Comprehensive Cancer Center Support42025
P30CA138313Medical University of South Carolina - Cancer Center Support Grant42025
P40OD010440Caenorhabditis Genetics Center42025
R37AR027883Cell adhesion and tissue dynamics in the skin42025

1 to 10 of 1,480Source NIH's project files

See all 1,480 nih grants

Papers2,697

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Divergent microtubule-organizing center strategies in mammalian gametogenesis.Trends Open202642761981PubTator, text miningPubMed
Liver Regeneration CRISPR Screen Identifies E3 Ligase NEURL1B Regulates Hepatocyte Mitosis by Destabilizing Microtubule-Organizing Centers.Gastroenterology202642600899PubTator, text miningPubMed
HURP Silencing Differentially Impacts Spindle Architecture and Metastatic Behavior in Breast Cancer Cell Lines.Int J Mol Sci202642450166PubTator, text miningPubMed
MBNL1-dependent alternative splicing promotes neuronal differentiation through regulation of NUMA1 exon 16 during fibroblast-to-neuron reprogramming.Front Cell Dev Biol202642440601PubTator, text miningPubMed
The nuclear structural protein NuMA is required for efficient DNA replication and supports the association of core replication factors to replication forks.DNA Repair (Amst)202642401126PubTator, text miningPubMed
Rare variants of GPSM2 associated with aneuploidy-mediated recurrent spontaneous abortion: mechanistic insights from siRNA knockdown modeling of hypothesized loss-of-function.Front Cell Dev Biol202642388972PubTator, text miningPubMed
Environmental Pollutant PCB 153 Is Associated with Candidate Alternative Splicing Alterations in Intellectual Disability-Associated Genes: An Exploratory RNA-Seq Splicing Analysis in a Neuronal Model.Genes (Basel)202642353851PubTator, text miningPubMed
NuMA1 controls myonuclear motility in striated skeletal muscle through AMPK activity and is impaired in Duchenne muscular dystrophy.Cell Death Dis202642310003PubTator, text miningPubMed
Canonical and noncanonical heterotrimeric G-protein signaling in uveal melanoma: Established mechanisms and emerging spindle-orientation hypotheses.Biochem Pharmacol202642214764PubTator, text miningPubMed
Chemical efflux imaging using an annular nanosensor array for in situ bladder cancer detection.Nat Nanotechnol202642204302PubTator, text miningPubMed

1 to 10 of 2,697

See all 2,697 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4926

GET https://conductscience.org/api/genes/v1/4926/patents?page=2