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Gene · 4939

OAS2: 2'-5'-oligoadenylate synthetase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. OAS2: 2'-5'-oligoadenylate synthetase 2. Genes, record 4939. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4939

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Gene

Symbol
OAS2
HGNC
Name
2'-5'-oligoadenylate synthetase 2
HGNC
NCBI Gene ID
4939
NCBI Gene
HGNC ID
HGNC:8087
HGNC
Ensembl
ENSG00000111335
NCBI Gene
Aliases
AIAISD2
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P297282'-5'-oligoadenylate synthase 27191Ensembl, GeneID, HGNC

Source UniProt

Patents25

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
WO 2026148146 A12026-07-0923P29728Espacenet
JP 2026004568 A2026-01-1435693P29728Espacenet
JP 2025062604 A2025-04-14135P29728Espacenet
US 11446398 B22022-09-20135P29728Espacenet
JP 2022524081 A2022-04-27103106P29728Espacenet
US 10846371 B22020-11-2420P29728Espacenet
US 10729784 B22020-08-0420P29728Espacenet
JP 2019054813 A2019-04-11216128P29728Espacenet
US 10207009 B22019-02-1920P29728Espacenet
JP 2017121241 A2017-07-13216128P29728Espacenet

1 to 10 of 25

See all 25 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,815

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleOAS2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant82025
P30AI027763UCSF-Bay Area Center for AIDS Research52025
P30AI073961Miami Center for AIDS Research52025
P51OD010425Washington National Primate Research Center52025
P51OD011132Emory National Primate Research Center52025
R01AI140442Betacoronaviruses: activation and antagonism of host innate immune responses52025
P51OD011133The Southwest National Primate Research Center42025
U19AI057266Vaccine and Infection Induced Immunity in the Young and Aged42025
UL1TR001863Yale Clinical and Translational Science Award42025
P30AI036214San Diego Center for AIDS Research (SD CFAR)32025

1 to 10 of 1,815Source NIH's project files

See all 1,815 nih grants

Papers2,192

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Advances in Cytosolic dsRNA Sensing of Viral Infections.Immunol Cell Biol202642802076PubTator, text miningPubMed
Hypomethylation of the Human OAS2 Gene in Blood Cells as a Potential Biomarker for Rheumatoid Arthritis: Findings from an Iranian Case-control Study.Arch Iran Med202642604416PubTator, text miningPubMed
Spatial decoupling of plaque and circulating immune programs defines a robust gene signature in atherosclerosis: A multi-cohort integrative analysis.Medicine (Baltimore)202642601724PubTator, text miningPubMed
IRF1 Inhibits Therapy-Induced Senescence of Glioblastoma Cells Through OAS2.Cells202642439626PubTator, text miningPubMed
Immunometabolic reprogramming of Mycobacterium tuberculosis-responsive memory CD4+ T cell subsets is linked to long-term protective immunity.Front Tuberc202642368172PubTator, text miningPubMed
Stage-specific disruption of erythropoiesis leads to anemia in newly diagnosed multiple myeloma patients.Front Cell Dev Biol202642358738PubTator, text miningPubMed
African swine fever virus pM448R protein promotes STUB1-mediated ubiquitin-proteasome degradation of IRF1 to attenuate type III interferon induction.J Virol202642262133PubTator, text miningPubMed
Alternative splicing broadens antiviral diversity at the human OAS2 locus.EMBO J202642236548PubTator, text miningPubMed
Differential Gene Expression in Human Upper Respiratory Tract Samples Identifies Antiviral Responses in Omicron SARS-CoV-2 Infection.Genes (Basel)202642194954PubTator, text miningPubMed
Genomic Profiling of Adults with Pharmacoresistant Genetic Generalized Epilepsy.Brain Sci202642192833PubTator, text miningPubMed

1 to 10 of 2,192

See all 2,192 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4939

GET https://conductscience.org/api/genes/v1/4939/patents?page=2