Gene · 4942
OAT: ornithine aminotransferase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. OAT: ornithine aminotransferase. Genes, record 4942. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4942
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P04181 | Ornithine aminotransferase, mitochondrial | 439 | 27 | Ensembl, GeneID, HGNC |
Source UniProt
Patents50
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 189 | P04181 | Espacenet |
| JP 2026067851 A | 2026-04-21 | 178 | P04181 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 56637 | P04181 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 8514 | P04181 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 8679 | P04181 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 8679 | P04181 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 8514 | P04181 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 32741 | P04181 | Espacenet |
| WO 2025036766 A1 | 2025-02-20 | 12 | P04181 | Espacenet |
| EP 4506468 A1 | 2025-02-12 | 12 | P04181 | Espacenet |
1 to 10 of 50
See all 50 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,216
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | OAT papers | Newest fiscal year |
|---|---|---|---|
| P30DA018310 | Neurometabolomics and Neuroproteomics Center on Cell-Cell Signaling | 8 | 2025 |
| R01CA260250 | Ornithine Aminotransferase Inactivation, a New Approach for Treatment of Cancers | 5 | 2025 |
| P30CA013696 | Cancer Center Support Grant | 4 | 2025 |
| P30CA036727 | Buffett Cancer Center Support Grant | 4 | 2025 |
| P30DK026743 | UCSF Liver Center | 4 | 2025 |
| U54GM104940 | Louisiana Clinical and Translational Science Center | 4 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 3 | 2025 |
| R01AG011085 | Ubiquitin‐mediated proteolysis and cell cycle control | 3 | 2025 |
| R01CA250227 | Investigating multifactorial beta-catenin activation in hepatocellular cancers | 3 | 2025 |
| R01EY032462 | Proline metabolism in retinal health | 3 | 2025 |
1 to 10 of 1,216Source NIH's project files
See all 1,216 nih grantsPapers2,040
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Pyridoxic Acid as a Novel Endogenous Biomarker for OAT-Mediated Clearance of Meropenem: A Population Pharmacokinetic Modeling and PK/PD-Response Analysis in Patients with Sepsis. | Pharmaceutics | 2026 | 42797288 | PubTator, text mining | PubMed |
| Cation encapsulation modulates oxygen atom transfer in O2-reducing Fe(ii) fluorinated alkoxide complexes. | Inorg Chem Front | 2026 | 42638956 | PubTator, text mining | PubMed |
| Design and Elucidation of a Strain-Relief-Driven Ring Opening Mechanism of Inactivation of Ornithine Aminotransferase by (1S,3R,5R)-3-Amino-6,6-difluorobicyclo[3.1.0]hexane-1-carboxylic Acid. | J Am Chem Soc | 2026 | 42619111 | PubTator, text mining | PubMed |
| Effects of PFOS and its substitute PFHxS on steroid hormone secretion, uptake, and transport in BeWo cells. | Ecotoxicol Environ Saf | 2026 | 42561515 | PubTator, text mining | PubMed |
| Ocular Toxicity of Systemic 5-Fluorouracil Chemotherapy: Role of Lacrimal Gland Transporters. | J Ocul Pharmacol Ther | 2026 | 42444152 | PubTator, text mining | PubMed |
| Mechanism-Based Inactivation of Human Ornithine Aminotransferase by Ethynyl- and Nitrile-Substituted Cyclopentene Analogues of γ-Aminobutyric Acids. | J Am Chem Soc | 2026 | 42429780 | PubTator, text mining | PubMed |
| Terminal 4q duplication and extended 10q deletion in a preterm infant with linear growth restriction: transcriptomic evidence of disrupted developmental and metabolic pathways. | Front Pediatr | 2026 | 42395604 | PubTator, text mining | PubMed |
| Region-specific dysregulation of proline metabolic enzymes underlying mitochondrial dysfunction in the postmortem brains of patients with schizophrenia. | J Psychiatr Res | 2026 | 42365847 | PubTator, text mining | PubMed |
| Integrated Multi-Omics Analysis and Experimental Validation Identify BCAT1 as a Critical Driver of Hepatocyte Pyroptosis in Acute-On-Chronic Liver Failure. | FASEB J | 2026 | 42258325 | PubTator, text mining | PubMed |
| Altered renal disposition of adefovir in metabolic dysfunction-associated steatohepatitis using the fast-food diet and thioacetamide-induced model to extrapolate renal secretion. | Drug Metab Dispos | 2026 | 42208114 | PubTator, text mining | PubMed |
1 to 10 of 2,040
See all 2,040 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4942
GET https://conductscience.org/api/genes/v1/4942/patents?page=2