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Gene · 4942

OAT: ornithine aminotransferase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. OAT: ornithine aminotransferase. Genes, record 4942. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4942

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Gene

Symbol
OAT
HGNC
Name
ornithine aminotransferase
HGNC
NCBI Gene ID
4942
NCBI Gene
HGNC ID
HGNC:8091
HGNC
Ensembl
ENSG00000065154
NCBI Gene
Aliases
GACR, HOGA, OATASE, OKT
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P04181Ornithine aminotransferase, mitochondrial43927Ensembl, GeneID, HGNC

Source UniProt

Patents50

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19189P04181Espacenet
JP 2026067851 A2026-04-21178P04181Espacenet
JP 2026004568 A2026-01-1456637P04181Espacenet
EP 4650780 A22025-11-198514P04181Espacenet
EP 4641201 A22025-10-298679P04181Espacenet
JP 2025517969 A2025-06-128679P04181Espacenet
JP 2025517970 A2025-06-128514P04181Espacenet
JP 2025032204 A2025-03-1132741P04181Espacenet
WO 2025036766 A12025-02-2012P04181Espacenet
EP 4506468 A12025-02-1212P04181Espacenet

1 to 10 of 50

See all 50 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,216

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleOAT papersNewest fiscal year
P30DA018310Neurometabolomics and Neuroproteomics Center on Cell-Cell Signaling82025
R01CA260250Ornithine Aminotransferase Inactivation, a New Approach for Treatment of Cancers52025
P30CA013696Cancer Center Support Grant42025
P30CA036727Buffett Cancer Center Support Grant42025
P30DK026743UCSF Liver Center42025
U54GM104940Louisiana Clinical and Translational Science Center42025
P30CA013148Comprehensive Cancer Center Support Grant32025
R01AG011085Ubiquitin‐mediated proteolysis and cell cycle control32025
R01CA250227Investigating multifactorial beta-catenin activation in hepatocellular cancers32025
R01EY032462Proline metabolism in retinal health32025

1 to 10 of 1,216Source NIH's project files

See all 1,216 nih grants

Papers2,040

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Pyridoxic Acid as a Novel Endogenous Biomarker for OAT-Mediated Clearance of Meropenem: A Population Pharmacokinetic Modeling and PK/PD-Response Analysis in Patients with Sepsis.Pharmaceutics202642797288PubTator, text miningPubMed
Cation encapsulation modulates oxygen atom transfer in O2-reducing Fe(ii) fluorinated alkoxide complexes.Inorg Chem Front202642638956PubTator, text miningPubMed
Design and Elucidation of a Strain-Relief-Driven Ring Opening Mechanism of Inactivation of Ornithine Aminotransferase by (1S,3R,5R)-3-Amino-6,6-difluorobicyclo[3.1.0]hexane-1-carboxylic Acid.J Am Chem Soc202642619111PubTator, text miningPubMed
Effects of PFOS and its substitute PFHxS on steroid hormone secretion, uptake, and transport in BeWo cells.Ecotoxicol Environ Saf202642561515PubTator, text miningPubMed
Ocular Toxicity of Systemic 5-Fluorouracil Chemotherapy: Role of Lacrimal Gland Transporters.J Ocul Pharmacol Ther202642444152PubTator, text miningPubMed
Mechanism-Based Inactivation of Human Ornithine Aminotransferase by Ethynyl- and Nitrile-Substituted Cyclopentene Analogues of γ-Aminobutyric Acids.J Am Chem Soc202642429780PubTator, text miningPubMed
Terminal 4q duplication and extended 10q deletion in a preterm infant with linear growth restriction: transcriptomic evidence of disrupted developmental and metabolic pathways.Front Pediatr202642395604PubTator, text miningPubMed
Region-specific dysregulation of proline metabolic enzymes underlying mitochondrial dysfunction in the postmortem brains of patients with schizophrenia.J Psychiatr Res202642365847PubTator, text miningPubMed
Integrated Multi-Omics Analysis and Experimental Validation Identify BCAT1 as a Critical Driver of Hepatocyte Pyroptosis in Acute-On-Chronic Liver Failure.FASEB J202642258325PubTator, text miningPubMed
Altered renal disposition of adefovir in metabolic dysfunction-associated steatohepatitis using the fast-food diet and thioacetamide-induced model to extrapolate renal secretion.Drug Metab Dispos202642208114PubTator, text miningPubMed

1 to 10 of 2,040

See all 2,040 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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