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Gene · 4967

OGDH: oxoglutarate dehydrogenase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. OGDH: oxoglutarate dehydrogenase. Genes, record 4967. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4967

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Gene

Symbol
OGDH
HGNC
Name
oxoglutarate dehydrogenase
HGNC
NCBI Gene ID
4967
NCBI Gene
HGNC ID
HGNC:8124
HGNC
Ensembl
ENSG00000105953
NCBI Gene
Aliases
AKGDH, E1k, E1o, HsOGDH, KGD1, OGDC, OGDC-E1, OGDH-E1, OGDH2, OGDHD
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q022182-oxoglutarate dehydrogenase complex component E11,0233Ensembl, GeneID, HGNC

Source UniProt

Patents29

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-21366Q02218Espacenet
JP 2026004568 A2026-01-1456752Q02218Espacenet
EP 4650780 A22025-11-19569Q02218Espacenet
JP 2025517970 A2025-06-12569Q02218Espacenet
JP 2023521663 A2023-05-25365Q02218Espacenet
US 11446398 B22022-09-2060641Q02218Espacenet
JP 2022524081 A2022-04-27163612Q02218Espacenet
JP 2021530985 A2021-11-18473Q02218Espacenet
WO 2021202604 A12021-10-07366Q02218Espacenet
WO 2020043864 A12020-03-051716Q02218Espacenet

1 to 10 of 29

See all 29 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,252

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleOGDH papersNewest fiscal year
P30CA016672Cancer Center Support Grant102025
P30CA008748Cancer Center Support Grant62025
P30CA177558University of Kentucky Markey Cancer Center – Cancer Center Support Grant62025
P01AG026572Perimenopause in Brain Aging and Alzheimer's Disease52025
R01HL152446Branched chain amino acids in heart failure42025
ZIABC011028Clinical Studies of the Molecular Genetic Basis of Kidney Cancer42025
ZIABC011038Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase Gene42025
I01BX002930HDAC7-driven metabolic remodeling in renal tumor progression32025
P30CA013696Cancer Center Support Grant32025
P30ES013508Center of Excellence in Environmental Toxicology32025

1 to 10 of 1,252Source NIH's project files

See all 1,252 nih grants

Papers1,711

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Alpha-ketoglutarate dehydrogenase and citric acid cycle flexibility in heart disease and failure.Am J Physiol Heart Circ Physiol202642809718PubTator, text miningPubMed
Exploration of Bacopa monnieri-derived Green Ligands for Targeted IDH1 Inhibition in Glioblastoma.Curr Drug Discov Technol202642764766PubTator, text miningPubMed
The mitochondria enzyme OGDH defends against disulfidptosis by licensing METTL3-regulated NRF2 translation.Nat Cell Biol202642567988PubTator, text miningPubMed
SLC25A1 drives lipid metabolic reprogramming promoting liver injury leading to hepatocellular carcinoma.Mol Biol Rep202642467147PubTator, text miningPubMed
Phillygenin suppresses hepatocellular carcinoma progression by modulating the TNF signaling pathway and TCA cycle metabolism.Front Pharmacol202642367287PubTator, text miningPubMed
Metabolic pathway signatures define prognostic subtypes of lung adenocarcinoma.Discov Oncol202642337154PubTator, text miningPubMed
Integrative analysis of left ventricle and epicardial adipose tissue identifies SDHA and OGDH as candidate targets for ischemic heart disease.iScience202642325549PubTator, text miningPubMed
Xylose-induced tricarboxylic acid cycle activation resensitizes gentamicin-resistant Escherichia coli.Appl Environ Microbiol202642283631PubTator, text miningPubMed
Heterozygous OGDH Variants Are Involved in Peripheral Neuropathy With Ataxia and Optical Atrophy.JIMD Rep202642266417PubTator, text miningPubMed
Process-level design of engineered microalgal-bacterial systems for carbon-efficient nitrogen removal from low C/N wastewater: carbon/electron redistribution revealed by metabolic network analysis.Environ Res202642225249PubTator, text miningPubMed

1 to 10 of 1,711

See all 1,711 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4967

GET https://conductscience.org/api/genes/v1/4967/patents?page=2