Gene · 4967
OGDH: oxoglutarate dehydrogenase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. OGDH: oxoglutarate dehydrogenase. Genes, record 4967. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4967
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q02218 | 2-oxoglutarate dehydrogenase complex component E1 | 1,023 | 3 | Ensembl, GeneID, HGNC |
Source UniProt
Patents29
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 366 | Q02218 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 56752 | Q02218 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 569 | Q02218 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 569 | Q02218 | Espacenet |
| JP 2023521663 A | 2023-05-25 | 365 | Q02218 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 60641 | Q02218 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 163612 | Q02218 | Espacenet |
| JP 2021530985 A | 2021-11-18 | 473 | Q02218 | Espacenet |
| WO 2021202604 A1 | 2021-10-07 | 366 | Q02218 | Espacenet |
| WO 2020043864 A1 | 2020-03-05 | 1716 | Q02218 | Espacenet |
1 to 10 of 29
See all 29 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,252
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | OGDH papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 10 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| P30CA177558 | University of Kentucky Markey Cancer Center – Cancer Center Support Grant | 6 | 2025 |
| P01AG026572 | Perimenopause in Brain Aging and Alzheimer's Disease | 5 | 2025 |
| R01HL152446 | Branched chain amino acids in heart failure | 4 | 2025 |
| ZIABC011028 | Clinical Studies of the Molecular Genetic Basis of Kidney Cancer | 4 | 2025 |
| ZIABC011038 | Molecular Therapeutics of Kidney Cancer: VHL Gene and Fumarate Hydratase Gene | 4 | 2025 |
| I01BX002930 | HDAC7-driven metabolic remodeling in renal tumor progression | 3 | 2025 |
| P30CA013696 | Cancer Center Support Grant | 3 | 2025 |
| P30ES013508 | Center of Excellence in Environmental Toxicology | 3 | 2025 |
1 to 10 of 1,252Source NIH's project files
See all 1,252 nih grantsPapers1,711
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Alpha-ketoglutarate dehydrogenase and citric acid cycle flexibility in heart disease and failure. | Am J Physiol Heart Circ Physiol | 2026 | 42809718 | PubTator, text mining | PubMed |
| Exploration of Bacopa monnieri-derived Green Ligands for Targeted IDH1 Inhibition in Glioblastoma. | Curr Drug Discov Technol | 2026 | 42764766 | PubTator, text mining | PubMed |
| The mitochondria enzyme OGDH defends against disulfidptosis by licensing METTL3-regulated NRF2 translation. | Nat Cell Biol | 2026 | 42567988 | PubTator, text mining | PubMed |
| SLC25A1 drives lipid metabolic reprogramming promoting liver injury leading to hepatocellular carcinoma. | Mol Biol Rep | 2026 | 42467147 | PubTator, text mining | PubMed |
| Phillygenin suppresses hepatocellular carcinoma progression by modulating the TNF signaling pathway and TCA cycle metabolism. | Front Pharmacol | 2026 | 42367287 | PubTator, text mining | PubMed |
| Metabolic pathway signatures define prognostic subtypes of lung adenocarcinoma. | Discov Oncol | 2026 | 42337154 | PubTator, text mining | PubMed |
| Integrative analysis of left ventricle and epicardial adipose tissue identifies SDHA and OGDH as candidate targets for ischemic heart disease. | iScience | 2026 | 42325549 | PubTator, text mining | PubMed |
| Xylose-induced tricarboxylic acid cycle activation resensitizes gentamicin-resistant Escherichia coli. | Appl Environ Microbiol | 2026 | 42283631 | PubTator, text mining | PubMed |
| Heterozygous OGDH Variants Are Involved in Peripheral Neuropathy With Ataxia and Optical Atrophy. | JIMD Rep | 2026 | 42266417 | PubTator, text mining | PubMed |
| Process-level design of engineered microalgal-bacterial systems for carbon-efficient nitrogen removal from low C/N wastewater: carbon/electron redistribution revealed by metabolic network analysis. | Environ Res | 2026 | 42225249 | PubTator, text mining | PubMed |
1 to 10 of 1,711
See all 1,711 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4967
GET https://conductscience.org/api/genes/v1/4967/patents?page=2