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OGG1: 8-oxoguanine DNA glycosylase

1 protein, 42 patents, 0 drugs, 0 trials, 2,257 NIH grants and 5,141 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolOGG1HGNC
Name8-oxoguanine DNA glycosylaseHGNC
NCBI Gene ID4968NCBI Gene
HGNC IDHGNC:8125HGNC
EnsemblENSG00000114026NCBI Gene
AliasesHMMH, HOGG1, MUTM, OGH1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
O15527N-glycosylase/DNA lyase34547Ensembl, GeneID, HGNCUniProt

Patents 42

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12624353 B22026-05-123937O15527Espacenet
US 12624354 B22026-05-123937O15527Espacenet
US 12570972 B22026-03-103937O15527Espacenet
US 12509680 B22025-12-303937O15527Espacenet
EP 4641201 A22025-10-296554O15527Espacenet
JP 2025147176 A2025-10-069761O15527Espacenet
JP 2025529142 A2025-09-047218O15527Espacenet
US 12371689 B22025-07-297218O15527Espacenet
JP 2025517969 A2025-06-126554O15527Espacenet
US 12281303 B22025-04-223937O15527Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 2257

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P01CA092584Structural Cell Biology of DNA Repair Machines512,025NIH's project files
ZIAAG000723ALZHEIMERS RESEARCH PROJECT: DNA repair dysfunction in neurodegeneration and Alzheimer's Disease182,025NIH's project files
P30ES010126UNC Center for Environmental Health and Susceptibility172,025NIH's project files
P30CA042014Cancer Center Support Grant162,025NIH's project files
P30CA047904Cancer Center Support Grant152,025NIH's project files
R01CA067985DNA Damage Repair by MUTYH and MUTYH Variants Associated with Colorectal Cancer152,025NIH's project files
R35ES031638Watching cooperative interactions between base and nucleotide excision repair proteins152,025NIH's project files
P30ES009089Center for Environmental Health in Northern Manhattan112,025NIH's project files
P30ES013508Center of Excellence in Environmental Toxicology112,025NIH's project files
P30CA060553The Robert H. Lurie Comprehensive Cancer Center92,025NIH's project files

Papers 5141

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42815649PubTator, text miningPubMed
42801551PubTator, text miningPubMed
42794848PubTator, text miningPubMed
42793066PubTator, text miningPubMed
42648838PubTator, text miningPubMed
42620046PubTator, text miningPubMed
42606642PubTator, text miningPubMed
42603455PubTator, text miningPubMed
42598744PubTator, text miningPubMed
42573227PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license