Gene · 4987
OPRL1: opioid related nociceptin receptor 1
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. OPRL1: opioid related nociceptin receptor 1. Genes, record 4987. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4987
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P41146 | Nociceptin receptor | 370 | 5 | Ensembl, GeneID, HGNC |
Source UniProt
Patents48
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2025529142 A | 2025-09-04 | 2952 | P41146 | Espacenet |
| US 12371689 B2 | 2025-07-29 | 2952 | P41146 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 60135 | P41146 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 60136 | P41146 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 60137 | P41146 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 326 | P41146 | Espacenet |
| US 11400116 B2 | 2022-08-02 | 6670 | P41146 | Espacenet |
| US 11352422 B2 | 2022-06-07 | 55 | P41146 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 163106 | P41146 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 163107 | P41146 | Espacenet |
1 to 10 of 48
See all 48 patentsDrugs4
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
Trials18
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
| Trial | Drug | Phase | Results first posted | Source |
|---|---|---|---|---|
| NCT06786637 | LY-2940094 | PHASE2 | ClinicalTrials.gov | |
| NCT06786637 | LY2940094 | PHASE2 | ClinicalTrials.gov | |
| NCT06423703 | CEBRANOPADOL | PHASE3 | ClinicalTrials.gov | |
| NCT05491785 | CEBRANOPADOL | PHASE1 | ClinicalTrials.gov | |
| NCT03608371 | LY-2940094 | PHASE2 | 2025-06-24 | ClinicalTrials.gov |
| NCT03193398 | LY-2940094 | PHASE2 | 2021-05-11 | ClinicalTrials.gov |
| NCT02031432 | CEBRANOPADOL | PHASE3 | 2020-01-18 | ClinicalTrials.gov |
| NCT01964378 | CEBRANOPADOL | PHASE3 | 2019-12-30 | ClinicalTrials.gov |
| NCT01939366 | CEBRANOPADOL | PHASE2 | 2019-12-26 | ClinicalTrials.gov |
| NCT01798303 | LY2940094 | PHASE2 | ClinicalTrials.gov |
1 to 10 of 18
See all 18 trialsNIH grants1,122
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | OPRL1 papers | Newest fiscal year |
|---|---|---|---|
| R01AA014351 | The Nociceptin ORL1 System: Treatment Target for Relapse | 18 | 2025 |
| P30CA008748 | Cancer Center Support Grant | 6 | 2025 |
| T32DA007237 | Neurobiology of Addiction Training Program | 5 | 2025 |
| R01DA008863 | Regulation Of Opioid Receptor Signaling by Endogenous Peptides | 4 | 2025 |
| R37AA017447 | Gene-environment interaction: the brain CRF system in alcohol preferring msP rats | 4 | 2025 |
| UL1TR001863 | Yale Clinical and Translational Science Award | 4 | 2025 |
| ZIAMH002852 | Clinical Evaluation of PET Radiotracers | 4 | 2025 |
| P30DA048736 | University of Washington Center of Excellence in Opioid Addiction Research | 3 | 2025 |
| P60AA006420 | CNS Effects of Alcohol: Cellular Neurobiology | 3 | 2025 |
| R01DA026472 | PET Imaging of neurochemical transmission in cocaine use disorders | 3 | 2025 |
1 to 10 of 1,122Source NIH's project files
See all 1,122 nih grantsPapers1,948
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Nociceptin orphanin F/Q Pathways are dysregulated by stress and modulate reward responsiveness and motivated behavior across species. | Mol Psychiatry | 2026 | 42763342 | PubTator, text mining | PubMed |
| Integrated Investigation of Sex Differences in the Human Nociceptin/Orphanin FQ Receptor System: Postmortem Analyses and In Vivo [11C]NOP-1A Positron Emission Tomography Imaging. | Biol Psychiatry Cogn Neurosci Neuroimaging | 2026 | 42648488 | PubTator, text mining | PubMed |
| Systematic Integration of genomics with transcriptomics for the Study of Coronary Artery Disease and Subclinical Atherosclerosis. | medRxiv | 2026 | 42620441 | PubTator, text mining | PubMed |
| Probing biomarkers and clinical utility of reward learning across species using the Probabilistic Reward Task: 20 years of findings. | Nat Ment Health | 2026 | 42582797 | PubTator, text mining | PubMed |
| Nociceptive Responses and Resting-State Functional Connectivity of the Human Midbrain Tegmentum. | Res Sq | 2026 | 42523566 | PubTator, text mining | PubMed |
| Biological correlates of cancer-related fatigue in older male cancer survivors. | Transl Psychiatry | 2026 | 42469198 | PubTator, text mining | PubMed |
| Potential Role of Nociceptin/Orphanin FQ in the Progression of Multiple Sclerosis. | bioRxiv | 2026 | 42465511 | PubTator, text mining | PubMed |
| "Alkaline-Hammer Strategy" Breaks Acidic and Stromal Barriers to Induce Alkaliptosis and Enhance Immunotherapy in Pancreatic Cancer. | Angew Chem Int Ed Engl | 2026 | 42454703 | PubTator, text mining | PubMed |
| Subtype-selective binding of milk β-casomorphins across the opioid receptor family revealed by molecular docking and molecular dynamics simulation. | J Dairy Sci | 2026 | 42431448 | PubTator, text mining | PubMed |
| Structural basis for dual targeting of μ-opioid and nociceptin/orphanin FQ receptors by Cebranopadol. | Acta Pharmacol Sin | 2026 | 42420592 | PubTator, text mining | PubMed |
1 to 10 of 1,948
See all 1,948 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/4987
GET https://conductscience.org/api/genes/v1/4987/patents?page=2