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Gene · 4987

OPRL1: opioid related nociceptin receptor 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. OPRL1: opioid related nociceptin receptor 1. Genes, record 4987. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4987

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Gene

Symbol
OPRL1
HGNC
Name
opioid related nociceptin receptor 1
HGNC
NCBI Gene ID
4987
NCBI Gene
HGNC ID
HGNC:8155
HGNC
Ensembl
ENSG00000125510
NCBI Gene
Aliases
KOR-3, KOR3, NOCIR, NOP, NOPr, OOR, OPRL, ORL1, PNOCR
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P41146Nociceptin receptor3705Ensembl, GeneID, HGNC

Source UniProt

Patents48

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2025529142 A2025-09-042952P41146Espacenet
US 12371689 B22025-07-292952P41146Espacenet
US 11446398 B22022-09-2060135P41146Espacenet
US 11446398 B22022-09-2060136P41146Espacenet
US 11446398 B22022-09-2060137P41146Espacenet
US 11400116 B22022-08-02326P41146Espacenet
US 11400116 B22022-08-026670P41146Espacenet
US 11352422 B22022-06-0755P41146Espacenet
JP 2022524081 A2022-04-27163106P41146Espacenet
JP 2022524081 A2022-04-27163107P41146Espacenet

1 to 10 of 48

See all 48 patents

Drugs4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
CEBRANOPADOLCHEMBL2364605Nociceptin receptor agonistAGONISTChEMBL
LY-2940094CHEMBL3304244Nociceptin receptor antagonistANTAGONISTChEMBL
LY2940094CHEMBL3545406Nociceptin receptor antagonistANTAGONISTChEMBL
SCH-486757CHEMBL4297427Nociceptin receptor agonistAGONISTChEMBL

Trials18

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT06786637LY-2940094PHASE2ClinicalTrials.gov
NCT06786637LY2940094PHASE2ClinicalTrials.gov
NCT06423703CEBRANOPADOLPHASE3ClinicalTrials.gov
NCT05491785CEBRANOPADOLPHASE1ClinicalTrials.gov
NCT03608371LY-2940094PHASE22025-06-24ClinicalTrials.gov
NCT03193398LY-2940094PHASE22021-05-11ClinicalTrials.gov
NCT02031432CEBRANOPADOLPHASE32020-01-18ClinicalTrials.gov
NCT01964378CEBRANOPADOLPHASE32019-12-30ClinicalTrials.gov
NCT01939366CEBRANOPADOLPHASE22019-12-26ClinicalTrials.gov
NCT01798303LY2940094PHASE2ClinicalTrials.gov

1 to 10 of 18

See all 18 trials

NIH grants1,122

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleOPRL1 papersNewest fiscal year
R01AA014351The Nociceptin ORL1 System: Treatment Target for Relapse182025
P30CA008748Cancer Center Support Grant62025
T32DA007237Neurobiology of Addiction Training Program52025
R01DA008863Regulation Of Opioid Receptor Signaling by Endogenous Peptides42025
R37AA017447Gene-environment interaction: the brain CRF system in alcohol preferring msP rats42025
UL1TR001863Yale Clinical and Translational Science Award42025
ZIAMH002852Clinical Evaluation of PET Radiotracers42025
P30DA048736University of Washington Center of Excellence in Opioid Addiction Research32025
P60AA006420CNS Effects of Alcohol: Cellular Neurobiology32025
R01DA026472PET Imaging of neurochemical transmission in cocaine use disorders32025

1 to 10 of 1,122Source NIH's project files

See all 1,122 nih grants

Papers1,948

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Nociceptin orphanin F/Q Pathways are dysregulated by stress and modulate reward responsiveness and motivated behavior across species.Mol Psychiatry202642763342PubTator, text miningPubMed
Integrated Investigation of Sex Differences in the Human Nociceptin/Orphanin FQ Receptor System: Postmortem Analyses and In Vivo [11C]NOP-1A Positron Emission Tomography Imaging.Biol Psychiatry Cogn Neurosci Neuroimaging202642648488PubTator, text miningPubMed
Systematic Integration of genomics with transcriptomics for the Study of Coronary Artery Disease and Subclinical Atherosclerosis.medRxiv202642620441PubTator, text miningPubMed
Probing biomarkers and clinical utility of reward learning across species using the Probabilistic Reward Task: 20 years of findings.Nat Ment Health202642582797PubTator, text miningPubMed
Nociceptive Responses and Resting-State Functional Connectivity of the Human Midbrain Tegmentum.Res Sq202642523566PubTator, text miningPubMed
Biological correlates of cancer-related fatigue in older male cancer survivors.Transl Psychiatry202642469198PubTator, text miningPubMed
Potential Role of Nociceptin/Orphanin FQ in the Progression of Multiple Sclerosis.bioRxiv202642465511PubTator, text miningPubMed
"Alkaline-Hammer Strategy" Breaks Acidic and Stromal Barriers to Induce Alkaliptosis and Enhance Immunotherapy in Pancreatic Cancer.Angew Chem Int Ed Engl202642454703PubTator, text miningPubMed
Subtype-selective binding of milk β-casomorphins across the opioid receptor family revealed by molecular docking and molecular dynamics simulation.J Dairy Sci202642431448PubTator, text miningPubMed
Structural basis for dual targeting of μ-opioid and nociceptin/orphanin FQ receptors by Cebranopadol.Acta Pharmacol Sin202642420592PubTator, text miningPubMed

1 to 10 of 1,948

See all 1,948 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

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