ConductScience.org, home

Library / Genes

OPRM1: opioid receptor mu 1

1 protein, 39 patents, 96 drugs, 1,779 trials, 4,728 NIH grants and 7,527 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolOPRM1HGNC
Nameopioid receptor mu 1HGNC
NCBI Gene ID4988NCBI Gene
HGNC IDHGNC:8156HGNC
EnsemblENSG00000112038NCBI Gene
AliasesLMOR, M-OR-1, MOP, MOR, MOR1, OPRMNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P35372Mu-type opioid receptor40035Ensembl, GeneID, HGNCUniProt

Patents 39

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12618828 B22026-05-0533P35372Espacenet
JP 2026004568 A2026-01-1456543P35372Espacenet
EP 4640849 A22025-10-29835P35372Espacenet
EP 4641201 A22025-10-295431P35372Espacenet
JP 2025154616 A2025-10-105P35372Espacenet
JP 2025529142 A2025-09-042953P35372Espacenet
US 12371689 B22025-07-292953P35372Espacenet
JP 2025519096 A2025-06-24835P35372Espacenet
JP 2025517969 A2025-06-125431P35372Espacenet
JP 2024521754 A2024-06-0448P35372Espacenet

Drugs 96

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
ALFENTANILCHEMBL634Mu opioid receptor agonistAGONISTChEMBL
ALFENTANIL HYDROCHLORIDECHEMBL1200531Mu opioid receptor agonistAGONISTChEMBL
ALVIMOPANCHEMBL270190Mu opioid receptor antagonistANTAGONISTChEMBL
ANILERIDINECHEMBL1201347Mu opioid receptor agonistAGONISTChEMBL
ANILERIDINE HYDROCHLORIDECHEMBL1201047Mu opioid receptor agonistAGONISTChEMBL
ANILERIDINE PHOSPHATECHEMBL1200543Mu opioid receptor agonistAGONISTChEMBL
AXELOPRANCHEMBL3137313Mu opioid receptor antagonistANTAGONISTChEMBL
AXOMADOLCHEMBL3989680Mu opioid receptor agonistAGONISTChEMBL
BENZHYDROCODONECHEMBL3137321Opioid receptors; mu/kappa/delta agonistAGONISTChEMBL
BENZHYDROCODONE HYDROCHLORIDECHEMBL3137310Opioid receptors; mu/kappa/delta agonistAGONISTChEMBL

Trials 1779

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT07606638TRAMADOLClinicalTrials.gov
NCT07584902SUFENTANILClinicalTrials.gov
NCT07568405REMIFENTANILClinicalTrials.gov
NCT07536594MORPHINEClinicalTrials.gov
NCT07532733REMIFENTANILClinicalTrials.gov
NCT07524738BUPRENORPHINEPHASE3ClinicalTrials.gov
NCT07513870REMIFENTANILClinicalTrials.gov
NCT07489625HYDROMORPHONE HYDROCHLORIDEEARLY_PHASE1ClinicalTrials.gov
NCT07484867OXYCODONEClinicalTrials.gov
NCT07435493FENTANYLClinicalTrials.gov

NIH grants 4728

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA008748Cancer Center Support Grant392,025NIH's project files
ZIAAA000301Integrative genetics of behavior with high throughput technologies282,025NIH's project files
U10AA008401Collaborative Study on the Genetics of Alcoholism (COGA).252,025NIH's project files
T32DA007027Training in the pharmacology of abused drugs202,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award202,025NIH's project files
P60AA007611Center on Genetic Determinants of Alcohol Ingestion and Responses to Alcohol192,025NIH's project files
P50AA012870Center for the Translational Neuroscience of Alcoholism172,025NIH's project files
P30AG028740University of Florida Older Americans Independence Center (OAIC)152,025NIH's project files
P30CA016672Cancer Center Support Grant142,025NIH's project files
R01DA008863Regulation Of Opioid Receptor Signaling by Endogenous Peptides142,025NIH's project files

Papers 7527

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42824314PubTator, text miningPubMed
42818637PubTator, text miningPubMed
42817590PubTator, text miningPubMed
42817043PubTator, text miningPubMed
42805076PubTator, text miningPubMed
42797389PubTator, text miningPubMed
42796507PubTator, text miningPubMed
42779750PubTator, text miningPubMed
42755511PubTator, text miningPubMed
42752995PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license