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Gene · 4998

ORC1: origin recognition complex subunit 1

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ORC1: origin recognition complex subunit 1. Genes, record 4998. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/4998

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Gene

Symbol
ORC1
HGNC
Name
origin recognition complex subunit 1
HGNC
NCBI Gene ID
4998
NCBI Gene
HGNC ID
HGNC:8487
HGNC
Ensembl
ENSG00000085840
NCBI Gene
Aliases
HSORC1, ORC1L, PARC1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q13415Origin recognition complex subunit 186114Ensembl, GeneID, HGNC

Source UniProt

Patents31

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456605Q13415Espacenet
JP 2026004568 A2026-01-1456606Q13415Espacenet
EP 4650780 A22025-11-198970Q13415Espacenet
EP 4641201 A22025-10-299227Q13415Espacenet
EP 4641202 A22025-10-295524Q13415Espacenet
JP 2025517969 A2025-06-129227Q13415Espacenet
JP 2025517970 A2025-06-128970Q13415Espacenet
KR 1020250017231 A2025-02-045524Q13415Espacenet
US 11446398 B22022-09-2060266Q13415Espacenet
US 11446398 B22022-09-2060267Q13415Espacenet

1 to 10 of 31

See all 31 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,706

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleORC1 papersNewest fiscal year
P01CA013106Targeting Transcription and Splicing in Cancer182025
P30CA016672Cancer Center Support Grant182025
P30CA008748Cancer Center Support Grant162025
R35GM131919The mechanism and regulation of autophagy142025
P30CA045508CSHL Cancer Center Support Grant122025
P30CA016056Roswell Park Cancer Center Support Grant112025
R01GM045436Initiation of DNA Replication at Cell Origins in Yeast92025
P30CA016086Cancer Center Support Grant82025
ZIABC010411Initiation of DNA Replication in Mammalian Cells82025
P30CA125123Baylor College of Medicine Cancer Center - Cancer Center Support Grant62025

1 to 10 of 1,706Source NIH's project files

See all 1,706 nih grants

Papers2,741

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Integrative omics profiling of CRELD2 in ccRCC: a nexus of genetics, prognosis, and tumor microenvironment.Inflamm Res202642700259PubTator, text miningPubMed
ATR-dependent phosphorylation of the histone acetyltransferase HBO1 suppresses chromatin binding and promotes replication stress responses.J Biol Chem202642575441PubTator, text miningPubMed
Exploring the Association Between Rheumatoid Arthritis and Parkinson's Disease: Evidence from 2001-2016 NHANES, Real-World Clinical Data and Bioinformatics Analysis.J Inflamm Res202642572743PubTator, text miningPubMed
FLCN loss is characterized by SQSTM1/p62 accumulation despite functional autophagy flux in Birt-Hogg-Dubé syndrome-associated kidney cancer.Autophagy Rep202642569319PubTator, text miningPubMed
Decoding early lung adenocarcinoma progression by single-cell and spatial transcriptomics reveals a CMA-related prognostic signature.Front Immunol202642495647PubTator, text miningPubMed
TOMM40/FADS2 Expression Ratio Predicts the Sensitivity to mTOR Inhibitors in Triple-Negative Breast Cancer.Cancer Med202642470318PubTator, text miningPubMed
5-Fluorouracil loaded copper‑aluminum layered double hydroxides inhibit colorectal cancer cells by inducing oxidative stress, mitochondrial membrane depolarization, apoptosis, and cell cycle arrest.Bioorg Chem202642456411PubTator, text miningPubMed
Ecological and evolutionary implications of a mobile genetic element-rich haloarchaeon with unique osmotic resilience.Microbiol Spectr202642379816PubTator, text miningPubMed
Emodin induces defensive autophagy against white spot syndrome virus infection via targeting the hemocyanin-mediated endoplasmic reticulum-mitochondrial crosstalk in shrimp.Autophagy202642329080PubTator, text miningPubMed
Targeting lysosomal pH restores mitochondrial quality control in GBA1-mutant Parkinson's disease.Transl Neurodegener202642310725PubTator, text miningPubMed

1 to 10 of 2,741

See all 2,741 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/4998

GET https://conductscience.org/api/genes/v1/4998/patents?page=2