Gene · 50
ACO2: aconitase 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. ACO2: aconitase 2. Genes, record 50. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/50
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| Q99798 | Aconitate hydratase, mitochondrial | 780 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents45
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 297 | Q99798 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 36054 | Q99798 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 324 | Q99798 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 324 | Q99798 | Espacenet |
| JP 2025062604 A | 2025-04-14 | 1396 | Q99798 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 23981 | Q99798 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 23981 | Q99798 | Espacenet |
| WO 2024214081 A1 | 2024-10-17 | 297 | Q99798 | Espacenet |
| US 11702671 B2 | 2023-07-18 | 48 | Q99798 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 23981 | Q99798 | Espacenet |
1 to 10 of 45
See all 45 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants821
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | ACO2 papers | Newest fiscal year |
|---|---|---|---|
| ZIAHD001602 | Regulation Of Intracellular Iron Metabolism | 9 | 2025 |
| ZIAHD008814 | Mammalian iron-sulfur cluster biogenesis | 5 | 2025 |
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| I01BX002930 | HDAC7-driven metabolic remodeling in renal tumor progression | 2 | 2025 |
| P01CA120964 | Molecular Pathogenesis of the Hamartoma Syndromes | 2 | 2025 |
| P30AG028740 | University of Florida Older Americans Independence Center (OAIC) | 2 | 2025 |
| P30CA012197 | Cancer Center Support Grant | 2 | 2025 |
| P30CA013148 | Comprehensive Cancer Center Support Grant | 2 | 2025 |
| P30CA016042 | Cancer Center Support Grant | 2 | 2025 |
| P30CA030199 | Cancer Center Support Grant (CCSG) | 2 | 2025 |
1 to 10 of 821Source NIH's project files
See all 821 nih grantsPapers1,282
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Triggering SORL1 Expression Restricts ccRCC Progression by Inducing Ubiquitination-Mediated c-Myc Degradation. | Cancer Sci | 2026 | 42698291 | PubTator, text mining | PubMed |
| A single-cell study of transcription and RNA splicing in MDD and ALC. | Eur Arch Psychiatry Clin Neurosci | 2026 | 42649423 | PubTator, text mining | PubMed |
| Mitochondrial hOGG1-2a overexpression sensitizes HeLaS3 cells to oxidative stress, accompanied by mitochondrial dysfunction and reduced mtDNA integrity. | Free Radic Res | 2026 | 42598744 | PubTator, text mining | PubMed |
| Nuclear-specific reductive carboxylation of alpha-ketoglutarate fuels histone acetylation to induce chromatin accessibility and gene activation. | Nat Commun | 2026 | 42386731 | PubTator, text mining | PubMed |
| Age-driven marbling in Haimen goat meat: multi-omics dissection of lipid/amino signatures and IMF regulatory networks. | Food Chem X | 2026 | 42382794 | PubTator, text mining | PubMed |
| Diagnostic Yield and Clinical Impact of Comprehensive WES/WGS Testing Beyond Common Genetic Causes in Hereditary Optic Atrophy. | Clin Genet | 2026 | 42363686 | PubTator, text mining | PubMed |
| Beyond proteostasis: LONP1 as an immunometabolic checkpoint in health and disease. | Biochem Pharmacol | 2026 | 42302976 | PubTator, text mining | PubMed |
| Pediatric hereditary optic neuropathies in the United Arab Emirates. | Ophthalmic Genet | 2026 | 42299460 | PubTator, text mining | PubMed |
| Aconitase 2 the rescue: A safeguard against excess mitochondrial citrate. | Mol Cell | 2026 | 42102741 | PubTator, text mining | PubMed |
| Iron: Regulation, redox homeostasis, and ferroptosis in cancer. | Ferroptosis Oxid Stress | 2026 | 42099806 | PubTator, text mining | PubMed |
1 to 10 of 1,282
See all 1,282 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/50
GET https://conductscience.org/api/genes/v1/50/patents?page=2