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Gene · 50

ACO2: aconitase 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. ACO2: aconitase 2. Genes, record 50. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/50

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Gene

Symbol
ACO2
HGNC
Name
aconitase 2
HGNC
NCBI Gene ID
50
NCBI Gene
HGNC ID
HGNC:118
HGNC
Ensembl
ENSG00000100412
NCBI Gene
Aliases
ACONM, HEL-S-284, ICRD, OCA8, OPA9
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
Q99798Aconitate hydratase, mitochondrial7800Ensembl, GeneID, HGNC

Source UniProt

Patents45

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19297Q99798Espacenet
JP 2026004568 A2026-01-1436054Q99798Espacenet
EP 4650780 A22025-11-19324Q99798Espacenet
JP 2025517970 A2025-06-12324Q99798Espacenet
JP 2025062604 A2025-04-141396Q99798Espacenet
JP 2025032204 A2025-03-1123981Q99798Espacenet
EP 4461818 A22024-11-1323981Q99798Espacenet
WO 2024214081 A12024-10-17297Q99798Espacenet
US 11702671 B22023-07-1848Q99798Espacenet
JP 2023058610 A2023-04-2523981Q99798Espacenet

1 to 10 of 45

See all 45 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants821

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleACO2 papersNewest fiscal year
ZIAHD001602Regulation Of Intracellular Iron Metabolism92025
ZIAHD008814Mammalian iron-sulfur cluster biogenesis52025
P30CA016672Cancer Center Support Grant42025
I01BX002930HDAC7-driven metabolic remodeling in renal tumor progression22025
P01CA120964Molecular Pathogenesis of the Hamartoma Syndromes22025
P30AG028740University of Florida Older Americans Independence Center (OAIC)22025
P30CA012197Cancer Center Support Grant22025
P30CA013148Comprehensive Cancer Center Support Grant22025
P30CA016042Cancer Center Support Grant22025
P30CA030199Cancer Center Support Grant (CCSG)22025

1 to 10 of 821Source NIH's project files

See all 821 nih grants

Papers1,282

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Triggering SORL1 Expression Restricts ccRCC Progression by Inducing Ubiquitination-Mediated c-Myc Degradation.Cancer Sci202642698291PubTator, text miningPubMed
A single-cell study of transcription and RNA splicing in MDD and ALC.Eur Arch Psychiatry Clin Neurosci202642649423PubTator, text miningPubMed
Mitochondrial hOGG1-2a overexpression sensitizes HeLaS3 cells to oxidative stress, accompanied by mitochondrial dysfunction and reduced mtDNA integrity.Free Radic Res202642598744PubTator, text miningPubMed
Nuclear-specific reductive carboxylation of alpha-ketoglutarate fuels histone acetylation to induce chromatin accessibility and gene activation.Nat Commun202642386731PubTator, text miningPubMed
Age-driven marbling in Haimen goat meat: multi-omics dissection of lipid/amino signatures and IMF regulatory networks.Food Chem X202642382794PubTator, text miningPubMed
Diagnostic Yield and Clinical Impact of Comprehensive WES/WGS Testing Beyond Common Genetic Causes in Hereditary Optic Atrophy.Clin Genet202642363686PubTator, text miningPubMed
Beyond proteostasis: LONP1 as an immunometabolic checkpoint in health and disease.Biochem Pharmacol202642302976PubTator, text miningPubMed
Pediatric hereditary optic neuropathies in the United Arab Emirates.Ophthalmic Genet202642299460PubTator, text miningPubMed
Aconitase 2 the rescue: A safeguard against excess mitochondrial citrate.Mol Cell202642102741PubTator, text miningPubMed
Iron: Regulation, redox homeostasis, and ferroptosis in cancer.Ferroptosis Oxid Stress202642099806PubTator, text miningPubMed

1 to 10 of 1,282

See all 1,282 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/50

GET https://conductscience.org/api/genes/v1/50/patents?page=2