Gene · 5007
OSBP: oxysterol binding protein
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. OSBP: oxysterol binding protein. Genes, record 5007. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5007
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P22059 | Oxysterol-binding protein 1 | 807 | 2 | Ensembl, GeneID, HGNC |
Source UniProt
Patents22
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026004568 A | 2026-01-14 | 56757 | P22059 | Espacenet |
| EP 4650780 A2 | 2025-11-19 | 2258 | P22059 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 1832 | P22059 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 1832 | P22059 | Espacenet |
| JP 2025517970 A | 2025-06-12 | 2258 | P22059 | Espacenet |
| JP 2025032204 A | 2025-03-11 | 32789 | P22059 | Espacenet |
| EP 4461818 A2 | 2024-11-13 | 32789 | P22059 | Espacenet |
| JP 2023058610 A | 2023-04-25 | 32789 | P22059 | Espacenet |
| US 11446398 B2 | 2022-09-20 | 60656 | P22059 | Espacenet |
| JP 2022524081 A | 2022-04-27 | 163627 | P22059 | Espacenet |
1 to 10 of 22
See all 22 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants752
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | OSBP papers | Newest fiscal year |
|---|---|---|---|
| ZIAHD000196 | Phosphoinositide-calcium Signaling In Cell Regulation | 15 | 2025 |
| P30DA018343 | Yale/NIDA Neuroproteomics Center | 8 | 2025 |
| R35GM119412 | Directing Membrane Function with Inositol Lipids in Health and Disease | 7 | 2025 |
| P30DK045735 | Yale Diabetes Research Center | 5 | 2025 |
| U54GM104938 | Oklahoma Shared Clinical and Translational Resources | 4 | 2025 |
| R35GM119768 | Spatial determinants in lipid metabolic organization at the sub-organelle level | 3 | 2025 |
| P30CA006927 | Comprehensive Cancer Center Program at Fox Chase | 2 | 2025 |
| P30CA043703 | Case Comprehensive Cancer Center Support Grant | 2 | 2025 |
| P30DK020579 | Diabetes Research Center | 2 | 2025 |
| P50AA011999 | Southern California Research Center for ALPD and Cirrhosis | 2 | 2025 |
1 to 10 of 752Source NIH's project files
See all 752 nih grantsPapers1,319
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
Divergent mechanistic reliance on the phosphatidylinositol 4-kinase (PI4K)/oxysterol-binding protein (OSBP) axis during Zika virus versus dengue virus and West Nile virus replication organelle biogenesis. | Virus Genes | 2026 | 42801443 | PubTator, text mining | PubMed |
| Cholesterol maintains the degradative capacity of lysosomes during clearance and recycling of dysfunctional mitochondria. | Nat Commun | 2026 | 42749740 | PubTator, text mining | PubMed |
| PRMT3 restricts porcine epidemic diarrhea virus replication by disrupting the interaction between VAPA and the viral nucleocapsid protein. | PLoS Pathog | 2026 | 42709888 | PubTator, text mining | PubMed |
| Targeting oxysterol-binding protein (OSBP) as a novel strategy to inhibit herpes simplex virus 2 (HSV-2) replication: First structure-activity relationship study of antiviral cholenamide derivatives. | Eur J Med Chem | 2026 | 42541847 | PubTator, text mining | PubMed |
| VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair. | Nat Commun | 2026 | 42393076 | PubTator, text mining | PubMed |
| Lipid transfer protein ORP3 mediates lysosomal repair via LC3B and ubiquitin-TAK1-p38 signaling. | bioRxiv | 2026 | 42327061 | PubTator, text mining | PubMed |
| Cholesterol transfer proteins promote Atg-independent ER clearance by lysosomes. | Cell Rep | 2026 | 42258351 | PubTator, text mining | PubMed |
| Split GFP-based fluorescent biosensors detect ER-Golgi membrane contact dynamics. | J Cell Sci | 2026 | 42252887 | PubTator, text mining | PubMed |
| Poliovirus 3Dpol polymerase region is essential for cleavage of poliovirus 3AB in vivo. | PLoS Pathog | 2026 | 42127148 | PubTator, text mining | PubMed |
| Minor lipids with major roles: Viral exploitation of phosphoinositides during RNA replication. | Virology | 2026 | 42114193 | PubTator, text mining | PubMed |
1 to 10 of 1,319
See all 1,319 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5007
GET https://conductscience.org/api/genes/v1/5007/patents?page=2