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Gene · 5007

OSBP: oxysterol binding protein

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. OSBP: oxysterol binding protein. Genes, record 5007. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5007

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Gene

Symbol
OSBP
HGNC
Name
oxysterol binding protein
HGNC
NCBI Gene ID
5007
NCBI Gene
HGNC ID
HGNC:8503
HGNC
Ensembl
ENSG00000110048
NCBI Gene
Aliases
OSBP1
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P22059Oxysterol-binding protein 18072Ensembl, GeneID, HGNC

Source UniProt

Patents22

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026004568 A2026-01-1456757P22059Espacenet
EP 4650780 A22025-11-192258P22059Espacenet
EP 4641201 A22025-10-291832P22059Espacenet
JP 2025517969 A2025-06-121832P22059Espacenet
JP 2025517970 A2025-06-122258P22059Espacenet
JP 2025032204 A2025-03-1132789P22059Espacenet
EP 4461818 A22024-11-1332789P22059Espacenet
JP 2023058610 A2023-04-2532789P22059Espacenet
US 11446398 B22022-09-2060656P22059Espacenet
JP 2022524081 A2022-04-27163627P22059Espacenet

1 to 10 of 22

See all 22 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants752

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleOSBP papersNewest fiscal year
ZIAHD000196Phosphoinositide-calcium Signaling In Cell Regulation152025
P30DA018343Yale/NIDA Neuroproteomics Center82025
R35GM119412Directing Membrane Function with Inositol Lipids in Health and Disease72025
P30DK045735Yale Diabetes Research Center52025
U54GM104938Oklahoma Shared Clinical and Translational Resources42025
R35GM119768Spatial determinants in lipid metabolic organization at the sub-organelle level32025
P30CA006927Comprehensive Cancer Center Program at Fox Chase22025
P30CA043703Case Comprehensive Cancer Center Support Grant22025
P30DK020579Diabetes Research Center22025
P50AA011999Southern California Research Center for ALPD and Cirrhosis22025

1 to 10 of 752Source NIH's project files

See all 752 nih grants

Papers1,319

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Divergent mechanistic reliance on the phosphatidylinositol 4-kinase (PI4K)/oxysterol-binding protein (OSBP) axis during Zika virus versus dengue virus and West Nile virus replication organelle biogenesis.
Virus Genes202642801443PubTator, text miningPubMed
Cholesterol maintains the degradative capacity of lysosomes during clearance and recycling of dysfunctional mitochondria.Nat Commun202642749740PubTator, text miningPubMed
PRMT3 restricts porcine epidemic diarrhea virus replication by disrupting the interaction between VAPA and the viral nucleocapsid protein.PLoS Pathog202642709888PubTator, text miningPubMed
Targeting oxysterol-binding protein (OSBP) as a novel strategy to inhibit herpes simplex virus 2 (HSV-2) replication: First structure-activity relationship study of antiviral cholenamide derivatives.Eur J Med Chem202642541847PubTator, text miningPubMed
VPS13C/PARK23 initiates lipid transfer and membrane remodeling for efficient lysosomal repair.Nat Commun202642393076PubTator, text miningPubMed
Lipid transfer protein ORP3 mediates lysosomal repair via LC3B and ubiquitin-TAK1-p38 signaling.bioRxiv202642327061PubTator, text miningPubMed
Cholesterol transfer proteins promote Atg-independent ER clearance by lysosomes.Cell Rep202642258351PubTator, text miningPubMed
Split GFP-based fluorescent biosensors detect ER-Golgi membrane contact dynamics.J Cell Sci202642252887PubTator, text miningPubMed
Poliovirus 3Dpol polymerase region is essential for cleavage of poliovirus 3AB in vivo.PLoS Pathog202642127148PubTator, text miningPubMed
Minor lipids with major roles: Viral exploitation of phosphoinositides during RNA replication.Virology202642114193PubTator, text miningPubMed

1 to 10 of 1,319

See all 1,319 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5007

GET https://conductscience.org/api/genes/v1/5007/patents?page=2