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Gene · 5009

OTC: ornithine transcarbamylase

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. OTC: ornithine transcarbamylase. Genes, record 5009. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5009

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Gene

Symbol
OTC
HGNC
Name
ornithine transcarbamylase
HGNC
NCBI Gene ID
5009
NCBI Gene
HGNC ID
HGNC:8512
HGNC
Ensembl
ENSG00000036473
NCBI Gene
Aliases
OCTD, OTC1, OTCD, OTCase
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P00480Ornithine transcarbamylase, mitochondrial3544Ensembl, GeneID, HGNC

Source UniProt

Patents121

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026067851 A2026-04-2161P00480Espacenet
JP 2025188163 A2025-12-2523P00480Espacenet
JP 2025169942 A2025-11-141192P00480Espacenet
EP 4641201 A22025-10-2952P00480Espacenet
JP 2025534674 A2025-10-171P00480Espacenet
EP 4602157 A22025-08-201P00480Espacenet
JP 2025525390 A2025-08-053660P00480Espacenet
JP 2025517969 A2025-06-1252P00480Espacenet
EP 4555087 A22025-05-2116P00480Espacenet
US 12297285 B22025-05-133660P00480Espacenet

1 to 10 of 121

See all 121 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants1,195

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleOTC papersNewest fiscal year
P30CA016672Cancer Center Support Grant42025
P30CA042014Cancer Center Support Grant42025
T32GM007526Medical Genetics Research Fellowship Program42025
U01HG008685eMERGE Phase IV Clinical Center at Mass General Brigham42025
ZIAHG200381Metabolism, infection and immunity in inborn errors of mitochondrial metabolism42025
P30DK048520Colorado Nutrition Obesity Research Center32025
P30DK056338Texas Medical Center Digestive Diseases Center32025
T32GM082773T32 training grant in medical genetics.32025
U01HG006379EHR-based Genomic Discovery and Implementation [Funded Extension]32025
U01HG008657eMERGE IV Northwest: A partnership to evaluate the use of genomic information in health care32025

1 to 10 of 1,195Source NIH's project files

See all 1,195 nih grants

Papers3,886

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
BRET-Based Mitochondrial Subcompartment Localization Biosensors Reveal the Impact of Pesticides and Food Additives on Mitochondrial Protein Localization.ACS Sens202642801737PubTator, text miningPubMed
Clinical, Biochemical, and Molecular Analyses of Three Patients with Urea Cycle Disorders in China.Ann Clin Lab Sci202642790946PubTator, text miningPubMed
Fate of long-term culture on hepatocyte-like cells generated from human adipose-derived mesenchymal stem cells.Stem Cells Transl Med202642759067PubTator, text miningPubMed
Elucidate the structural role of helper lipids in modulating hepatic expression following repeated intravenous administration of mRNA-LNPs.Mater Today Bio202642718620PubTator, text miningPubMed
Engineered genomic attachment sites for site-specific recombinases enable high-efficiency integration in plants and human cells.Nat Biotechnol202642687044PubTator, text miningPubMed
Refractory Hyperammonemic Encephalopathy as a Paraneoplastic Presentation of Fibrolamellar Hepatocellular Carcinoma: A Case Report.Am J Case Rep202642634231PubTator, text miningPubMed
Clinical and genetic analysis of Liver-Predominant ornithine transcarbamylase deficiency caused by a novel de novo OTC sequence variant in a female child.Gene202642542173PubTator, text miningPubMed
Gut metaproteomics reveals activated arginine catabolism and impaired arginine biosynthesis in systemic lupus erythematosus.mSystems202642429656PubTator, text miningPubMed
Functional editing of the OTC locus by targeted integration with phenotype correction and restoration of endogenous expression patterns.Mol Ther202642427028PubTator, text miningPubMed
Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review).Int J Mol Med202642272250PubTator, text miningPubMed

1 to 10 of 3,886

See all 3,886 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5009

GET https://conductscience.org/api/genes/v1/5009/patents?page=2