Gene · 5009
OTC: ornithine transcarbamylase
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. OTC: ornithine transcarbamylase. Genes, record 5009. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5009
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P00480 | Ornithine transcarbamylase, mitochondrial | 354 | 4 | Ensembl, GeneID, HGNC |
Source UniProt
Patents121
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026067851 A | 2026-04-21 | 61 | P00480 | Espacenet |
| JP 2025188163 A | 2025-12-25 | 23 | P00480 | Espacenet |
| JP 2025169942 A | 2025-11-14 | 1192 | P00480 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 52 | P00480 | Espacenet |
| JP 2025534674 A | 2025-10-17 | 1 | P00480 | Espacenet |
| EP 4602157 A2 | 2025-08-20 | 1 | P00480 | Espacenet |
| JP 2025525390 A | 2025-08-05 | 3660 | P00480 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 52 | P00480 | Espacenet |
| EP 4555087 A2 | 2025-05-21 | 16 | P00480 | Espacenet |
| US 12297285 B2 | 2025-05-13 | 3660 | P00480 | Espacenet |
1 to 10 of 121
See all 121 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants1,195
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | OTC papers | Newest fiscal year |
|---|---|---|---|
| P30CA016672 | Cancer Center Support Grant | 4 | 2025 |
| P30CA042014 | Cancer Center Support Grant | 4 | 2025 |
| T32GM007526 | Medical Genetics Research Fellowship Program | 4 | 2025 |
| U01HG008685 | eMERGE Phase IV Clinical Center at Mass General Brigham | 4 | 2025 |
| ZIAHG200381 | Metabolism, infection and immunity in inborn errors of mitochondrial metabolism | 4 | 2025 |
| P30DK048520 | Colorado Nutrition Obesity Research Center | 3 | 2025 |
| P30DK056338 | Texas Medical Center Digestive Diseases Center | 3 | 2025 |
| T32GM082773 | T32 training grant in medical genetics. | 3 | 2025 |
| U01HG006379 | EHR-based Genomic Discovery and Implementation [Funded Extension] | 3 | 2025 |
| U01HG008657 | eMERGE IV Northwest: A partnership to evaluate the use of genomic information in health care | 3 | 2025 |
1 to 10 of 1,195Source NIH's project files
See all 1,195 nih grantsPapers3,886
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| BRET-Based Mitochondrial Subcompartment Localization Biosensors Reveal the Impact of Pesticides and Food Additives on Mitochondrial Protein Localization. | ACS Sens | 2026 | 42801737 | PubTator, text mining | PubMed |
| Clinical, Biochemical, and Molecular Analyses of Three Patients with Urea Cycle Disorders in China. | Ann Clin Lab Sci | 2026 | 42790946 | PubTator, text mining | PubMed |
| Fate of long-term culture on hepatocyte-like cells generated from human adipose-derived mesenchymal stem cells. | Stem Cells Transl Med | 2026 | 42759067 | PubTator, text mining | PubMed |
| Elucidate the structural role of helper lipids in modulating hepatic expression following repeated intravenous administration of mRNA-LNPs. | Mater Today Bio | 2026 | 42718620 | PubTator, text mining | PubMed |
| Engineered genomic attachment sites for site-specific recombinases enable high-efficiency integration in plants and human cells. | Nat Biotechnol | 2026 | 42687044 | PubTator, text mining | PubMed |
| Refractory Hyperammonemic Encephalopathy as a Paraneoplastic Presentation of Fibrolamellar Hepatocellular Carcinoma: A Case Report. | Am J Case Rep | 2026 | 42634231 | PubTator, text mining | PubMed |
| Clinical and genetic analysis of Liver-Predominant ornithine transcarbamylase deficiency caused by a novel de novo OTC sequence variant in a female child. | Gene | 2026 | 42542173 | PubTator, text mining | PubMed |
| Gut metaproteomics reveals activated arginine catabolism and impaired arginine biosynthesis in systemic lupus erythematosus. | mSystems | 2026 | 42429656 | PubTator, text mining | PubMed |
| Functional editing of the OTC locus by targeted integration with phenotype correction and restoration of endogenous expression patterns. | Mol Ther | 2026 | 42427028 | PubTator, text mining | PubMed |
| Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review). | Int J Mol Med | 2026 | 42272250 | PubTator, text mining | PubMed |
1 to 10 of 3,886
See all 3,886 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5009
GET https://conductscience.org/api/genes/v1/5009/patents?page=2