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Gene · 5015

OTX2: orthodenticle homeobox 2

12 sourcesgene-search-2026-11-11-0.2.0

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ConductScience Library. OTX2: orthodenticle homeobox 2. Genes, record 5015. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5015

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Gene

Symbol
OTX2
HGNC
Name
orthodenticle homeobox 2
HGNC
NCBI Gene ID
5015
NCBI Gene
HGNC ID
HGNC:8522
HGNC
Ensembl
ENSG00000165588
NCBI Gene
Aliases
CPHD6, MCOPS5
NCBI Gene
Type
protein-coding
NCBI Gene

Proteins1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated in
P32243Homeobox protein OTX22890Ensembl, GeneID, HGNC

Source UniProt

Patents42

Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.

PublicationPublishedSEQ ID NOProteinSource
JP 2026515744 A2026-05-19228P32243Espacenet
JP 2026004568 A2026-01-1456653P32243Espacenet
JP 2026004568 A2026-01-1456655P32243Espacenet
EP 4641201 A22025-10-296652P32243Espacenet
JP 2025147176 A2025-10-0615450P32243Espacenet
JP 2025517969 A2025-06-126652P32243Espacenet
JP 2025028160 A2025-02-2815450P32243Espacenet
KR 1020250010750 A2025-01-2115450P32243Espacenet
WO 2024214081 A12024-10-17228P32243Espacenet
JP 2024109657 A2024-08-1415289P32243Espacenet

1 to 10 of 42

See all 42 patents

Drugs0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

None in this release.

Trials0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

None in this release.

NIH grants2,064

NIH grants whose papers are about the gene, through NIH's grant-paper links.

GrantTitleOTX2 papersNewest fiscal year
P30CA008748Cancer Center Support Grant122025
R01CA159859Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma122025
P30EY001730Vision Research Core112025
R01EY012543Vulnerable and Resilient Cells in Retinal Degeneration102025
R01EY021482Stimulation of Retinal Regeneration102025
R01EY024605Choriocapillaris Protection and Replacement in AMD92025
R24HD000836Laboratory of Developmental Biology92025
P01HL141084Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology82025
P01CA096832NORMAL & NEOPLASTIC GROWTH IN THE BRAIN72025
P30CA021765Cancer Center Support Grant (CCSG)72025

1 to 10 of 2,064Source NIH's project files

See all 2,064 nih grants

Papers2,975

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

TitleJournalYearPMIDFound bySource
Evolution of MAF and OTX families during the emergence and stabilization of rod photoreceptors across Metazoans.Res Sq202642818957PubTator, text miningPubMed
Paedomorphic Patterns of Gene Expression in the Eyes of Brook Salamanders.Integr Comp Biol202642747168PubTator, text miningPubMed
Understanding septo-optic dysplasia: Endocrine implications and ophthalmic consequences.Best Pract Res Clin Endocrinol Metab202642697756PubTator, text miningPubMed
Genomic Profiling of Anophthalmia/Microphthalmia-Associated CNVs Reveals Complex Genotype-Phenotype Correlations and Incomplete Penetrance.Mol Genet Genomic Med202642695167PubTator, text miningPubMed
Niche-Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids.Adv Sci (Weinh)202642675788PubTator, text miningPubMed
Molecular and Clinical Analyses of 111 Patients with Bilateral Anterior-Segment Dysgenesis/Aniridia and Microphthalmia/Anophthalmia.Ophthalmol Sci202642667103PubTator, text miningPubMed
Multimodal neuroimaging changes and their behavioral, genetic, and neurotransmitter correlates in electroconvulsive therapy for major depressive disorder.Prog Neuropsychopharmacol Biol Psychiatry202642595040PubTator, text miningPubMed
3D epigenomic landscape of the human retinal pigment epithelium.Proc Natl Acad Sci U S A202642555638PubTator, text miningPubMed
METTL3-dependent m⁶A maturation of miR-140-3p contributes to hippocampal neuronal apoptosis through the OTX2/Wnt/β-catenin axis under chronic stress.Mol Biol Rep202642550296PubTator, text miningPubMed
Multi-Ancestry Genome-Wide Association with Fine-Mapping Identifies Novel Loci for Pigment Dispersion Syndrome and Pigmentary Glaucoma.Ophthalmol Glaucoma202642508691PubTator, text miningPubMed

1 to 10 of 2,975

See all 2,975 papers

Sources 12

  • ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
  • ChEMBL, through Open TargetsCC BY-SA 3.0
  • ClinicalTrials.govNo license stated
  • EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
  • GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
  • HGNCCC0
  • NCBI GenePublic domain (US government)
  • NIH's project files and grant-paper linksPublic domain
  • Open TargetsCC0 1.0
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0
Each source's terms
  • ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
  • ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • ClinicalTrials.govnone stated
  • EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
  • GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
  • HGNCCC0: https://www.genenames.org/about/license/
  • NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
  • NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
  • Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
  • PubMedNLM's terms
  • PubTator 3Public domain
  • UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license

ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

For software

Read this gene from software.

The record and each of its lists are JSON, twenty rows a page. No key.

GET https://conductscience.org/api/genes/v1/5015

GET https://conductscience.org/api/genes/v1/5015/patents?page=2