Gene · 5015
OTX2: orthodenticle homeobox 2
12 sourcesgene-search-2026-11-11-0.2.0
Cite this record
ConductScience Library. OTX2: orthodenticle homeobox 2. Genes, record 5015. Release gene-search-2026-11-11-0.2.0, 11 Nov 2026. https://conductscience.org/library/genes/5015
On this page
Gene
Proteins1
Reviewed human proteins whose Swiss-Prot entry states the gene.
| UniProt entry | Protein | Length | Structures | Gene stated in |
|---|---|---|---|---|
| P32243 | Homeobox protein OTX2 | 289 | 0 | Ensembl, GeneID, HGNC |
Source UniProt
Patents42
Patents whose sequence listing contains this protein's exact sequence. A patent can list a sequence without claiming it.
| Publication | Published | SEQ ID NO | Protein | Source |
|---|---|---|---|---|
| JP 2026515744 A | 2026-05-19 | 228 | P32243 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 56653 | P32243 | Espacenet |
| JP 2026004568 A | 2026-01-14 | 56655 | P32243 | Espacenet |
| EP 4641201 A2 | 2025-10-29 | 6652 | P32243 | Espacenet |
| JP 2025147176 A | 2025-10-06 | 15450 | P32243 | Espacenet |
| JP 2025517969 A | 2025-06-12 | 6652 | P32243 | Espacenet |
| JP 2025028160 A | 2025-02-28 | 15450 | P32243 | Espacenet |
| KR 1020250010750 A | 2025-01-21 | 15450 | P32243 | Espacenet |
| WO 2024214081 A1 | 2024-10-17 | 228 | P32243 | Espacenet |
| JP 2024109657 A | 2024-08-14 | 15289 | P32243 | Espacenet |
1 to 10 of 42
See all 42 patentsDrugs0
Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.
None in this release.
Trials0
Trials of those drugs. A trial joins the gene only through a drug that acts on it.
None in this release.
NIH grants2,064
NIH grants whose papers are about the gene, through NIH's grant-paper links.
| Grant | Title | OTX2 papers | Newest fiscal year |
|---|---|---|---|
| P30CA008748 | Cancer Center Support Grant | 12 | 2025 |
| R01CA159859 | Dysregulation of the Core Binding Factor Complex Inhibits Differentiation and Drives Group 4 Medulloblastoma | 12 | 2025 |
| P30EY001730 | Vision Research Core | 11 | 2025 |
| R01EY012543 | Vulnerable and Resilient Cells in Retinal Degeneration | 10 | 2025 |
| R01EY021482 | Stimulation of Retinal Regeneration | 10 | 2025 |
| R01EY024605 | Choriocapillaris Protection and Replacement in AMD | 9 | 2025 |
| R24HD000836 | Laboratory of Developmental Biology | 9 | 2025 |
| P01HL141084 | Multiscale Systems to Elucidate Susceptibility and Cardioprotective Mechanisms in Cardio-oncology | 8 | 2025 |
| P01CA096832 | NORMAL & NEOPLASTIC GROWTH IN THE BRAIN | 7 | 2025 |
| P30CA021765 | Cancer Center Support Grant (CCSG) | 7 | 2025 |
1 to 10 of 2,064Source NIH's project files
See all 2,064 nih grantsPapers2,975
Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.
| Title | Journal | Year | PMID | Found by | Source |
|---|---|---|---|---|---|
| Evolution of MAF and OTX families during the emergence and stabilization of rod photoreceptors across Metazoans. | Res Sq | 2026 | 42818957 | PubTator, text mining | PubMed |
| Paedomorphic Patterns of Gene Expression in the Eyes of Brook Salamanders. | Integr Comp Biol | 2026 | 42747168 | PubTator, text mining | PubMed |
| Understanding septo-optic dysplasia: Endocrine implications and ophthalmic consequences. | Best Pract Res Clin Endocrinol Metab | 2026 | 42697756 | PubTator, text mining | PubMed |
| Genomic Profiling of Anophthalmia/Microphthalmia-Associated CNVs Reveals Complex Genotype-Phenotype Correlations and Incomplete Penetrance. | Mol Genet Genomic Med | 2026 | 42695167 | PubTator, text mining | PubMed |
| Niche-Mediated Neural Priming Enables Robust and Scalable Generation of Human Choroid Plexus Organoids. | Adv Sci (Weinh) | 2026 | 42675788 | PubTator, text mining | PubMed |
| Molecular and Clinical Analyses of 111 Patients with Bilateral Anterior-Segment Dysgenesis/Aniridia and Microphthalmia/Anophthalmia. | Ophthalmol Sci | 2026 | 42667103 | PubTator, text mining | PubMed |
| Multimodal neuroimaging changes and their behavioral, genetic, and neurotransmitter correlates in electroconvulsive therapy for major depressive disorder. | Prog Neuropsychopharmacol Biol Psychiatry | 2026 | 42595040 | PubTator, text mining | PubMed |
| 3D epigenomic landscape of the human retinal pigment epithelium. | Proc Natl Acad Sci U S A | 2026 | 42555638 | PubTator, text mining | PubMed |
| METTL3-dependent m⁶A maturation of miR-140-3p contributes to hippocampal neuronal apoptosis through the OTX2/Wnt/β-catenin axis under chronic stress. | Mol Biol Rep | 2026 | 42550296 | PubTator, text mining | PubMed |
| Multi-Ancestry Genome-Wide Association with Fine-Mapping Identifies Novel Loci for Pigment Dispersion Syndrome and Pigmentary Glaucoma. | Ophthalmol Glaucoma | 2026 | 42508691 | PubTator, text mining | PubMed |
1 to 10 of 2,975
See all 2,975 papersSources 12
- ClinicalTrials.gov's posted results, through CTTI's AACTFreely available. Acknowledgement requested
- ChEMBL, through Open TargetsCC BY-SA 3.0
- ClinicalTrials.govNo license stated
- EMBL-EBI's patent proteinsNo added restrictions. Attribution expected
- GenBank's patent filesNo restrictions from NCBI. Submitters may hold rights
- HGNCCC0
- NCBI GenePublic domain (US government)
- NIH's project files and grant-paper linksPublic domain
- Open TargetsCC0 1.0
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0
Each source's terms
- ClinicalTrials.gov's posted results, through CTTI's AACTClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299
- ChEMBL, through Open TargetsCC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- ClinicalTrials.govnone stated
- EMBL-EBI's patent proteinsEMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use
- GenBank's patent filesGenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/
- HGNCCC0: https://www.genenames.org/about/license/
- NCBI GeneNone named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/
- NIH's project files and grant-paper linksPublic domain (NIH RePORTER)
- Open TargetsCC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence
- PubMedNLM's terms
- PubTator 3Public domain
- UniProtCC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license
ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.
For software
Read this gene from software.
The record and each of its lists are JSON, twenty rows a page. No key.
GET https://conductscience.org/api/genes/v1/5015
GET https://conductscience.org/api/genes/v1/5015/patents?page=2