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P2RX7: purinergic receptor P2X 7

1 protein, 52 patents, 5 drugs, 7 trials, 2,133 NIH grants and 4,934 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolP2RX7HGNC
Namepurinergic receptor P2X 7HGNC
NCBI Gene ID5027NCBI Gene
HGNC IDHGNC:8537HGNC
EnsemblENSG00000089041NCBI Gene
AliasesMGC20089, P2X7NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
Q99572P2X purinoceptor 75954Ensembl, GeneID, HGNCUniProt

Patents 52

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
EP 4676521 A12026-01-14141Q99572Espacenet
EP 4640849 A22025-10-29853Q99572Espacenet
EP 4641201 A22025-10-295592Q99572Espacenet
JP 2025147176 A2025-10-0616576Q99572Espacenet
JP 2025529142 A2025-09-043318Q99572Espacenet
US 12371689 B22025-07-293318Q99572Espacenet
EP 4587067 A12025-07-231Q99572Espacenet
EP 4587464 A12025-07-231Q99572Espacenet
EP 4587465 A12025-07-231Q99572Espacenet
JP 2025098188 A2025-07-013Q99572Espacenet

Drugs 5

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
AZD9056CHEMBL3545108P2X purinoceptor 7 antagonistANTAGONISTChEMBL
CE-224535CHEMBL1823817P2X purinoceptor 7 antagonistANTAGONISTChEMBL
EVT401CHEMBL3707396P2X purinoceptor 7 antagonistANTAGONISTChEMBL
GSK1482160CHEMBL1222883P2X purinoceptor 7 negative allosteric modulatorNEGATIVE ALLOSTERIC MODULATORChEMBL
JNJ-54175446CHEMBL4079239P2X purinoceptor 7 antagonistANTAGONISTChEMBL

Trials 7

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT04116606JNJ-54175446PHASE2ClinicalTrials.gov
NCT02902601JNJ-54175446PHASE1ClinicalTrials.gov
NCT00920608AZD9056PHASE1ClinicalTrials.gov
NCT00628095CE-224535PHASE22022-04-04ClinicalTrials.gov
NCT00520572AZD9056PHASE22010-10-04ClinicalTrials.gov
NCT00446784CE-224535PHASE1ClinicalTrials.gov
NCT00418782CE-224535PHASE2ClinicalTrials.gov

NIH grants 2133

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30EY001583P30 Core Grant For Vision Research162,025NIH's project files
R01AI015614Pathogenesis of Fever in Man102,025NIH's project files
R01AI038903T Cell Homeostasis72,025NIH's project files
P30CA008748Cancer Center Support Grant52,025NIH's project files
R01HL136389The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial Arrhythmogenesis52,025NIH's project files
R37AI063331Cryopyrin/NLRP3 Signaling in Inflammation and Innate Immunity52,025NIH's project files
ZIAHD000195Intracellular Signaling In Endocrine Cells52,025NIH's project files
R01DK103723Regulation of enteric motor neurocircuits by enteric glia in health and disease42,025NIH's project files
R01HL131517Sex-specific arrhythmogenic mechanisms of atrial fibrillation42,025NIH's project files
T32EY007035Research on normal and abnormal mechanisms of vision42,025NIH's project files

Papers 4934

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42820025PubTator, text miningPubMed
42806194PubTator, text miningPubMed
42762605PubTator, text miningPubMed
42744122PubTator, text miningPubMed
42726185PubTator, text miningPubMed
42725023PubTator, text miningPubMed
42711601PubTator, text miningPubMed
42709297PubTator, text miningPubMed
42700186PubTator, text miningPubMed
42693241PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license