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P4HB: prolyl 4-hydroxylase subunit beta

1 protein, 157 patents, 4 drugs, 17 trials, 3,315 NIH grants and 5,893 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolP4HBHGNC
Nameprolyl 4-hydroxylase subunit betaHGNC
NCBI Gene ID5034NCBI Gene
HGNC IDHGNC:8548HGNC
EnsemblENSG00000185624NCBI Gene
AliasesCLCRP1, DSI, ERBA2L, GIT, P4Hbeta, PDI, PDIA1, PHDB, PO4DB, PO4HB, PROHBNCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P07237Protein disulfide-isomerase50814Ensembl, GeneID, HGNCUniProt

Patents 157

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
WO 2026193074 A12026-09-1771P07237Espacenet
JP 2026004568 A2026-01-1459314P07237Espacenet
EP 4650780 A22025-11-195741P07237Espacenet
JP 2025147176 A2025-10-069949P07237Espacenet
JP 2025531239 A2025-09-1926P07237Espacenet
JP 2025529142 A2025-09-047261P07237Espacenet
US 12371689 B22025-07-297261P07237Espacenet
EP 4587581 A22025-07-2326P07237Espacenet
JP 2025517970 A2025-06-125741P07237Espacenet
EP 4553160 A12025-05-142P07237Espacenet

Drugs 4

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource
IMPLITAPIDECHEMBL2105804Microsomal triglyceride transfer protein inhibitorINHIBITORChEMBL
LOMITAPIDECHEMBL354541Microsomal triglyceride transfer protein inhibitorINHIBITORChEMBL
LOMITAPIDE MESYLATECHEMBL2105662Microsomal triglyceride transfer protein inhibitorINHIBITORChEMBL
SLX-4090CHEMBL4297326Microsomal triglyceride transfer protein inhibitorINHIBITORChEMBL

Trials 17

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource
NCT02765841LOMITAPIDEPHASE3ClinicalTrials.gov
NCT02434744SLX-4090PHASE2ClinicalTrials.gov
NCT02399852LOMITAPIDEClinicalTrials.gov
NCT02173158LOMITAPIDEPHASE32018-10-10ClinicalTrials.gov
NCT02135705LOMITAPIDEClinicalTrials.gov
NCT01675154SLX-4090PHASE22021-08-19ClinicalTrials.gov
NCT01556906LOMITAPIDEPHASE22013-02-22ClinicalTrials.gov
NCT00943306LOMITAPIDEPHASE32018-05-11ClinicalTrials.gov
NCT00871936SLX-4090PHASE2ClinicalTrials.gov
NCT00810979SLX-4090PHASE2ClinicalTrials.gov

NIH grants 3315

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
P30CA016672Cancer Center Support Grant162,025NIH's project files
T32HL007917Program in Blood Coagulation and Vascular Biology102,025NIH's project files
P30CA008748Cancer Center Support Grant92,025NIH's project files
P30DK020572Michigan Diabetes Research Center (MDRC)92,025NIH's project files
P30CA030199Cancer Center Support Grant (CCSG)72,025NIH's project files
UL1TR001863Yale Clinical and Translational Science Award72,025NIH's project files
P30CA138313Medical University of South Carolina - Cancer Center Support Grant62,025NIH's project files
P30CA021765Cancer Center Support Grant (CCSG)52,025NIH's project files
P30CA046934University of Colorado Cancer Center Support Grant52,025NIH's project files
P30DK034854Integrated Epithelial and Muscosal Biology52,025NIH's project files

Papers 5893

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42791904PubTator, text miningPubMed
42787651PubTator, text miningPubMed
42757385PubTator, text miningPubMed
42694352PubTator, text miningPubMed
42623842PubTator, text miningPubMed
42575981PubTator, text miningPubMed
42573850PubTator, text miningPubMed
42536397PubTator, text miningPubMed
42517226PubTator, text miningPubMed
42481880PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license