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FURIN: furin, paired basic amino acid cleaving enzyme

1 protein, 211 patents, 0 drugs, 0 trials, 6,172 NIH grants and 11,554 papers.

Gene 7

Its symbol and name are HGNC's, unless HGNC and NCBI Gene contradict each other.

FieldValueSource
SymbolFURINHGNC
Namefurin, paired basic amino acid cleaving enzymeHGNC
NCBI Gene ID5045NCBI Gene
HGNC IDHGNC:8568HGNC
EnsemblENSG00000140564NCBI Gene
AliasesFUR, PACE, PCSK3, SPC1NCBI Gene
Typeprotein-codingNCBI Gene

Proteins 1

Reviewed human proteins whose Swiss-Prot entry states the gene.

UniProt entryProteinLengthStructuresGene stated inSource
P09958Furin79448Ensembl, GeneID, HGNCUniProt

Patents 211

Patents whose sequence listing holds the protein exactly: the same sequence, by SHA-256, length and CRC-64. A sequence a patent lists is not always one it claims.

PublicationPublishedSEQ ID NOProteinSource
US 12605438 B22026-04-212P09958Espacenet
EP 4705273 A22026-03-11189P09958Espacenet
EP 4705273 A22026-03-11569P09958Espacenet
JP 2026004568 A2026-01-1446780P09958Espacenet
EP 4650780 A22025-11-192653P09958Espacenet
EP 4641201 A22025-10-292235P09958Espacenet
JP 2025147176 A2025-10-065599P09958Espacenet
JP 2025147176 A2025-10-065600P09958Espacenet
JP 2025147176 A2025-10-065601P09958Espacenet
JP 2025529142 A2025-09-041620P09958Espacenet

Drugs 0

Drugs a ChEMBL mechanism record says act on the gene's protein, through Open Targets.

DrugChEMBL IDMechanismActionSource

Trials 0

Trials of those drugs. A trial joins the gene only through a drug that acts on it.

TrialDrugPhaseResults first postedSource

NIH grants 6172

NIH projects whose papers are about the gene, through NIH's grant-paper links.

ProjectTitleIts papers about the geneNewest fiscal yearSource
UM1AI144462Consortium for HIV/AIDS Vaccine Development322,025NIH's project files
P50CA098252SPORE in Cervical Cancer282,025NIH's project files
ZIAAI005024Design Of Immunogens202,025NIH's project files
P30CA008748Cancer Center Support Grant162,025NIH's project files
UM1AI144371Induction of protective antibodies for HIV vaccine development162,025NIH's project files
ZIABC009052Understanding Papillomavirus Virion Proteins and Vaccines162,025NIH's project files
P30CA013330Cancer Center Support Grant152,025NIH's project files
ZIAAI000938Paramyxoviruses as Vaccine Vectors Against Highly Pathogenic Viruses152,025NIH's project files
P30CA006927Comprehensive Cancer Center Program at Fox Chase142,025NIH's project files
R01AI145687Structural definition of CD4-induced HIV-1 Env conformational changes required for infection132,025NIH's project files

Papers 11554

Newest first. Swiss-Prot's references are curated; PubTator's text mining finds papers that name the gene, not always ones about it.

PMIDFound bySource
42822865PubTator, text miningPubMed
42808726PubTator, text miningPubMed
42734358PubTator, text miningPubMed
42724475PubTator, text miningPubMed
42697502PubTator, text miningPubMed
42668958PubTator, text miningPubMed
42585295PubTator, text miningPubMed
42580475PubTator, text miningPubMed
42567511PubTator, text miningPubMed
42555639PubTator, text miningPubMed

The same record as JSON

Release gene-search-2026-11-11-0.1.0

ClinicalTrials.gov's posted results, through CTTI's AACT: ClinicalTrials.gov data via Aggregate Analysis of ClinicalTrials.gov (AACT), CTTI. CTTI makes its materials freely available and requests acknowledgement. https://aact.ctti-clinicaltrials.org/documentation/299 ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

ChEMBL, through Open Targets: CC BY-SA 3.0, for the parts from ChEMBL. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

ClinicalTrials.gov: none stated ClinicalTrials.gov's data carry an international copyright outside the United States: https://clinicaltrials.gov/about-site/terms-conditions.

EMBL-EBI's patent proteins: EMBL-EBI's patent protein files from the EPO, JPO, KIPO and USPTO. EMBL-EBI: "EMBL-EBI itself places no additional restrictions on the use or redistribution of the data available via its Data Resources and Tools other than those provided by the original data owners" and "EMBL-EBI expects attribution (e.g. in publications, services or products) for the use of any of its Data Resources and Tools." Read on 11 Nov 2026 at https://www.ebi.ac.uk/about/terms-of-use

GenBank's patent files: GenBank's patent files. NCBI: "NCBI places no restrictions on the use or distribution of the GenBank data. However, some submitters may claim patent, copyright, or other intellectual property rights in all or a portion of the data they have submitted." Read on 11 Nov 2026 at https://www.ncbi.nlm.nih.gov/genbank/about/

HGNC: CC0: https://www.genenames.org/about/license/

NCBI Gene: None named for the file. NCBI says information created by or for the US government on its site is in the public domain, and asks that NLM be acknowledged: https://www.ncbi.nlm.nih.gov/home/about/policies/

NIH's project files and grant-paper links: Public domain (NIH RePORTER)

Open Targets: CC0 1.0. Open Targets asks that users cite its latest paper: Buniello et al. 2025, Open Targets Platform: facilitating therapeutic hypotheses building in drug discovery, Nucleic Acids Research 53(D1):D1467, PMID 39657122. Read on 8 Nov 2026 at https://platform-docs.opentargets.org/licence

PubTator 3: Public domain

UniProt: CC BY 4.0. UniProt's licence file: "All databases and documents in the UniProt FTP directory may be copied and redistributed freely, without advance permission, provided that this copyright statement is reproduced with each copy." UniProt asks that users cite its latest paper: The UniProt Consortium, UniProt: the Universal Protein Knowledgebase in 2025, Nucleic Acids Research 53:D609-D617, https://doi.org/10.1093/nar/gkae1010. Read on 9 Nov 2026 at https://www.uniprot.org/help/license